Clinical trials: Liver Disease Parenchymal
Liver Disease Parenchymal
Bloody or Well Done. How Would You Like Your Liver Biopsy, Sir?
This is a randomized comparative trial between percutaneous liver biopsy and EUS FNB guided liver biopsy in patients with parenchymal liver disease.
- Trial name
- LIMPID (NCT06231082)
- Testing
- Group one - percutaneous (P), Group two - EUS FNB (E)
- Where
- Romania
- Volunteers
- 78 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs in chemotherapy, such as ifosfamide, carboplatin, and etoposide, work in different ways to stop the growth of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00788125
- Testing
- carboplatin, dasatinib, etoposide phosphate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- City of Hope Medical Center
Liver Dysfunction, Pain
Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery
The patient population requiring hepatic resection can demonstrate an unpredictable risk of exhibiting peri-operative coagulopathy resulting either from the pre-operative hepatic pathophysiology or volume of parenchymal…
- Trial name
- RITM-IVM (NCT00553553)
- Testing
- Morphine sulphate, Morphine hydrochloride, remifentanil hydrochloride
- Where
- Ireland
- Volunteers
- 45 people
- Sponsor
- St Vincent's University Hospital, Ireland
Colorectal Cancer Stage IV
Parenchymal Sparing Hepatectomy in Post-chemotherapy Liver Atrophy
Major hepatectomy in patients with colorectal liver metastases (CLM) and post-chemotherapy liver atrophy is associated with increased complications.
- Trial name
- NCT06329700
- Testing
- Hepatectomy
- Volunteers
- 74 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Metabolic Dysfunction-Associated Steatotic Liver Disease, Hepatic Steatosis
Quantitative Ultrasound (RS85 and R20) for Liver Fat Quantification in MASLD Using MRI-PDFF as Reference
This multicenter prospective study aims to evaluate the correlation between quantitative ultrasound fat fraction (USFF) and MRI-PDFF (Proton Density Fat Fraction) for liver fat quantification in patients with metabolic…
- Conditions
- Metabolic Dysfunction-Associated Steatotic Liver Disease, Hepatic Steatosis, Liver Disease Parenchymal
- Trial name
- DeepUSFF (NCT07192159)
- Testing
- Quantitative ultrasound (DeepUSFF)
- Where
- 2 sites in United States, South Korea
- Volunteers
- 182 people
- Sponsor
- Seoul National University Hospital
Liver Surgery, MINIMALLY INVASIVE LIVER SURGERY
Safety and Economics of Parenchymal Transection in Minimally Invasive Liver Surgery
LIVER-MIND 2 is a multicentre, observational, retrospective registry coordinated by the SICE HPB and Minimally Invasive Surgery Working Group, enrolling consecutive adults undergoing elective minimally invasive (laparoscopic…
- Conditions
- Liver Surgery, MINIMALLY INVASIVE LIVER SURGERY, Liver Neoplasm
- Trial name
- LIVER-MIND 2 (NCT07750275)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Molise
Hemostasis, General Surgery
A Study Evaluating the Safety and Preliminary Efficacy of sFilm-FS in Controlling Parenchymal Bleeding During Elective Hepatic Surgery
The Study investigates a new product, sFilm-FS, aimed to help controlling body fluid leakage in general surgery procedures, proposing its use as an adjunct to hemostasis and/or sealing.
- Trial name
- NCT04660721
- Testing
- sFilm-FS, TACHOSIL®
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 33 people
- Sponsor
- Sealantium Medical Ltd.
Hepatocellular Carcinoma (HCC), Liver Cancer, Adult
Utilize Imaging to Assess Changes in Hepatocellular Carcinoma Perfusion as Potentiated by Intra-Arterial Nitroglycerin
This is a single-arm, open-label, single-center, first-in-human feasibility study evaluating parenchymal blood volume (PBV) imaging as a tool to dynamically assess perfusional changes in hepatocellular carcinoma (HCC) potentiated…
- Trial name
- NCT07682454
- Testing
- Parenchymal Blood Volume (PBV) Imaging, Nitroglycerin, Medical Record Review
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Liver Failure
A Study on Relationship Between Resected Normal Liver Parenchymal Volume（RNLV）and Post-Hepatectomy Liver Failure (PHLF)
The post-hepatotectomy liver failure (PHLF) is still the most worrisome complication of hepatic resection. Surgeons have always been making efforts to preoperatively predict PHLF using kinds of techniques, scoring systems, and…
- Trial name
- RNLV (NCT06366048)
- Testing
- the different definitions of PHLF according to 50-50 criteria and ISGLS criteria
- Where
- 3 sites in China
- Volunteers
- 1,600 people
- Sponsor
- National Natural Science Foundation of China
Liver Surgery, Minimal Invasive Surgery
High Versus Low Pneumoperitoneum PressUre for Parenchymal Transection in Minimally Invasive Major Liver Surgery
Minimally invasive techniques in liver surgery gain popularity as they facilitate postoperative recovery while achieving comparable oncologic outcomes to the open approach.
- Conditions
- Liver Surgery, Minimal Invasive Surgery, Major Liver Resection
- Trial name
- PPULS (NCT06770803)
- Testing
- High Pressure Pneumoperitoneum, Low Pressure Pneumoperitoneum
- Volunteers
- 132 people
- Sponsor
- University Hospital Heidelberg
End Stage Liver Disease
Spray Diathermy Versus Harmonic Scalpel Technique for Hepatic Parenchymal Transection
Consecutive patients, who were treated for end stage liver cirrhosis by LDLT were included in this a prospective study.Patients enrolled in the study divided into two groups according to the day of surgery.
- Trial name
- LDLT (NCT02617498)
- Testing
- harmonic scalpel, spray mode diathermy
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Obesity, Liver Disease Parenchymal
Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery
Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis.
- Trial name
- NCT06372015
- Testing
- Nutritional Approach, Surgery Approach
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Liver Cirrhosis
EUS-guided Versus Percutaneous Ultrasound-guided Biopsy for Parenchymal Liver Disease
Liver biopsy may be indicated in various clinical scenarios to help diagnose and manage liver diseases. Endoscopic ultrasound (EUS) liver biopsy and percutaneous USG guided liver biopsy are two methods used to obtain liver tissue…
- Trial name
- NCT06047327
- Testing
- EUS guided liver biopsy, Percutaneous Liver Biopsy
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India