Clinical trials: Liver Function Failure
Cirrhosis, Hepatic Encephalopathy
Factors Associated With End Stage Liver Disease
100 ambulatory cirrhotic patients attending a liver transplant clinic will undergo a comprehensive clinical evaluation for severity of liver disease, anemia, depression, and fatigue.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Fatigue, Depression
- Trial name
- NCT01846819
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
End Stage Renal Disease, End Stage Liver Disease
Dissemination of the Donor Application: Utilizing Social Media to Identify Potential Live Organ Donors
This study utilizes a web-based application to help patients on the organ transplant waitlist communicate patient's need for a living donor via social media and provide interested potential donors the opportunity to engage with…
- Trial name
- NCT03803423
- Testing
- The Donor App
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heart Failure, Respiratory Failure
Donor Simvastatin Treatment in Organ Transplantation
The aim of the study is to investigate the effects of donor simvastatin treatment on ischemia-reperfusion injury after heart transplantation.
- Conditions
- Heart Failure, Respiratory Failure, Liver Failure, Kidney Failure
- Trial name
- SIMVA (NCT01160978)
- Testing
- Simvastatin 80mg, Control Rx
- Where
- Finland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Renal Failure, Hepatic Failure
The Role of Skin Microbiota in Hepatic or Renal Pruritus
Various neurotransmitters may share in the pathogenesis of hepatic and renal itching. Skin microbiota may share in the pathogenesis of pruritus.
- Conditions
- Renal Failure, Hepatic Failure, Pruritus
- Trial name
- NCT05604469
- Testing
- Isolation of skin microbiota
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hepatic Encephalopathy, Liver Cirrhosis
Diagnosing Minimal Hepatic Encephalopathy
Our purpose is to 1. Examine the correlation between MDF in a resting EEG, recorded just before the CRT test, and the variance in reaction times indicated by the CRT index 2.
- Trial name
- MindTheLiver (NCT05433948)
- Testing
- Simultaneous EEG and CRT
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Acute-On-Chronic Liver Failure, Cirrhosis and Chronic Liver Disease
Exploring Biomarkers Predicting the Outcome of Acute-on-chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is an ailment with high incidence of multiorgan failure (MOF) and consequent mortality. Systemic inflammation and susceptibility to infection are characteristic pathophysiological features.
- Trial name
- PGE2 (NCT02965560)
- Testing
- plasma suPAR, PGE2 measurement. Other biomarkers were just recorded from clinical laboratory.
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Clostridium Difficile Infection, Multi Drug Resistant Organisms
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal Diseases
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with Clostridium Difficile (CDI), subjects affected by Multi Drug Resistant Organisms (MDRO) infection…
- Conditions
- Clostridium Difficile Infection, Multi Drug Resistant Organisms, Chronic Inflammatory Bowel Disease, Irritable Bowel Syndrome
- Trial name
- BIOMIS-Gastr (NCT04698148)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- 3 sites in Italy
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Alcoholic Liver Disease
Cognitive Function of Alcoholic Compensated Liver Cirrhosis
Differences in cognitive function between patients with viral and alcoholic compensated liver cirrhosis
- Trial name
- NCT04557774
- Testing
- Cognitive function test
- Where
- South Korea
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Hepatic Failure
Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment
The primary purpose of this study is to evaluate the effect of hepatic impairment on the systemic pharmacokinetics, safety, and tolerability of icenticaftor in participants with varying degrees of hepatic impairment.
- Trial name
- NCT04587622
- Testing
- Icenticaftor
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLF
There is very little data related to the natural history of disease from covert HE (MHE and grade 1 HE) to overt HE (grades II, III and IV) in ACLF, with implications on long-term neurological recovery after an episode of overt…
- Conditions
- Hepatic Encephalopathy, Acute-On-Chronic Liver Failure, Decompensated Cirrhosis
- Trial name
- NCT05421351
- Where
- India
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hepatic Encephalopathy
Quantitative Determination of Brain Water Content in Patients During and After Hepatic Encepalopathy
There is increasing evidence that the pathophysiology of hepatic encephalopathy (HE) is tightly associated with low-grade cerebral edema. Uptake of ammonia in astrocytes leads to osmotic swelling caused by glutamine formation.
- Trial name
- NCT02177708
- Where
- Denmark
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hepatic Impairment, Healthy Volunteers
A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function
The main aim is to check the effect of a single dose of soticlestat in adults with moderate or mild liver failure compared to healthy adults with normal liver function. Participants will check into the study clinic for 8 days.
- Trial name
- NCT05098054
- Testing
- Soticlestat
- Where
- 6 sites in United States, Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Takeda
Liver Cirrhosis, Hepatic Encephalopathy
Diagnosis of Covert/Minimal Hepatic Encephalopathy by Means of Continuous Reaction Time Measurement
The investigators wish to investigate how the Continuous Reaction Time (CRT) method can be used in the diagnosis and monitoring of covert hepatic encephalopathy (cHE)in patients with cirrhosis of the liver.
- Trial name
- NCT01773538
- Testing
- Lactulose and rifaximin, Branched Chain amino acids
- Where
- 2 sites in Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Mette Munk Lauridsen
Hepatic Encephalopathy, Covert Hepatic Encephalopathy
Utility of the Clamping Bean Test (CBT) for Covert Hepatic Encephalopathy Screening
Hepatic encephalopathy is a brain dysfunction caused by liver insufficiency and/or porto-systemic shunt. It manifests as a wide spectrum of neurological or psychiatric abnormalities ranging from subclinical alterations to coma.
- Trial name
- NCT06367127
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Liver Cirrhosis, Liver Failure
Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"
The purpose of this study is to evaluate the effects on plasma exchange with 5% albumin on albumin functional capacity, cardiocirculatory, renal and cerebral function in cirrhotic patients with "acute-on-chronic liver failure".
- Trial name
- NCT01201720
- Testing
- Plasma exchange with albumin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Grifols, S.A.
Drug-Induced Liver Injury, Liver Failure
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy Subjects
The objectives are to: 1. validate a panel of tissue-specific miRNAs that are differentially expressed in the plasma of patients with and without liver injuries 2.
- Trial name
- NCT03000621
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Liver Cirrhoses, Hepatic Encephalopathy
Role of MRI in Detection of Minimal Hepatic Encephalopathy
Introduction Liver cirrhosis (LC) is irreversible fibrosis of the liver (1) and it remains a public health problem. One of the complications of the cirrhosis is hepatic encephalopathy (HE) which is defined as brain dysfunction…
- Trial name
- NCT04131205
- Testing
- Magnetic Resonance Imaging
- Where
- Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Liver Disease, Cirrhosis of the Liver
MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease
This study is to investigate MER receptor tyrosine kinase (MERTK) signalling cascade on monocytes and tissue macrophages in respect to innate immune function of the cells in patients with cirrhosis at different stages of disease…
- Conditions
- Liver Disease, Cirrhosis of the Liver, Acute-On-Chronic Liver Failure, Liver Failure
- Trial name
- NCT04116242
- Testing
- blood sampling for research purpose, clinical data collection, Health-related Questionnaires
- Where
- 4 sites in Switzerland, United Kingdom
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hepatic Encephalopathy
Microbiota, Sarcopenia, and Hepatic Encephalopathy Change in Cirrhotic Patients Before and After Rehabilitation
Through this plan, it will provide many benefits to patients with liver cirrhosis complicated with sarcopenia and/or hepatic encephalopathy, their family members, and the government in Taiwan: 1.
- Trial name
- NCT06040814
- Testing
- Rehabilitation Training
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital