Clinical trials: Liver Inflammation
Chronic Hepatitis C
Use or Non-use of Epoetin Beta in Patients Infected by Chronic Hepatitis C
The purpose is to demonstrate a correction of anemia in hepatitis C virus treatment with peginterferon plus ribavirin.
- Trial name
- NCT00262379
- Testing
- epoetin beta (NeoRecormon®)
- Where
- 37 sites in France
- Volunteers
- 229 people
- Sponsor
- University Hospital, Angers
Chronic Hepatitis c
Anti-E1E2 (D32.10 Epitope-binding) Antibodies Status Prior Therapy Favors Direct-acting Antiviral Treatment Efficacy
The hypothesis was to check whether baseline anti-E1E2 antibodies could predict virological outcome in Hepatitis C virus (HCV)-infected patients receiving direct-acting antiviral treatment
- Trial name
- NCT03348059
- Testing
- Direct-acting antiviral therapy
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Hospices Civils de Lyon
Liver Transplantation, Hepatitis B
Prophylaxis of Hepatitis B Virus Recurrence After Liver Transplantation
Entecavir demonstrated superior virologic and biochemical benefits over lamivudine and adefovir. The investigators evaluated the effect of entecavir combined Hepatitis B immune globulin (HBIG) with lamivudine or adefovir or both…
- Trial name
- NCT01139203
- Testing
- lamivudine adefovir entecavir HBIG
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Chronic Hepatitis C
Patient Self-management and Gene Guided Therapy for Chronic Hepatitis C
This study will explore ways to improve the effectiveness of patient Self Management at a time when genetic test results guide new treatments that will dramatically increase the possibility of cure of the hepatitis C virus.The…
- Trial name
- NCT02006823
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Hepatitis C, Chronic
Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C
The purpose of this study is to examine the efficacy of irbesartan on the progression of liver fibrosis in adult patients with chronic hepatitis C. The expected total enrollment is 200 patients.
- Trial name
- Fibrosar (NCT00265642)
- Testing
- Irbesartan
- Where
- France
- Volunteers
- 166 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Hepatocellular Carcinoma
DAA in the Risk of Recurrence After Curative Treatment of HCC
For early stage of HCC, surgical resection or radiofrequency ablation (RFA) is the mainstay curative treatments. However, recurrence is still a major issue after the surgery or RFA.
- Trial name
- NCT02959359
- Testing
- Ledipasvir 90mg/Sofosbuvir 400 mg, Ribavirin
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hepatitis C Virus Infection, Treatment Side Effects
Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) for Patients With Hepatitis C Virus Infection
The investigators aim to assess the effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) for 12 weeks in hepatitis C virus (HCV)-infected patients who fail to prior NS5A-containing DAA regimens and HCV…
- Conditions
- Hepatitis C Virus Infection, Treatment Side Effects, Adherence, Treatment, Effect of Drug
- Trial name
- NCT05092074
- Testing
- Vosevi 400/100/100 Oral Tablet
- Where
- 15 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Hepatitis C, HIV Infections
Associations, Outcomes and Genomics of GB Virus C, Hepatitis C Virus and Human Immunodeficiency Virus Infection
The purpose of this study is to examine the effect of GB virus C (GBV-C) on the natural history of chronic hepatitis C virus (HCV) infection in subjects co-infected with HIV and HCV.
- Trial name
- NCT00164060
- Where
- Australia
- Volunteers
- 158 people
- Sponsor
- Bayside Health
Hepatitis C
Evaluation of Treatment of Chronic HCV Patients in Chronic Kidney Disease Versus End Stage Renal Disease Patients
1. To asses curability of( Ombitasvir ,Paritaprevir,Ritonavir) in chronic HCV infected patients in those with CKD versus ESRD in Assiut Hospital University . 2.
- Trial name
- NCT03341988
- Testing
- Ombitasvir-Paritaprevir-Ritonavir Tab 12.5-75-50 milligram
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Chronic Disease, Hepatitis C
Evaluating a Telehealth Treatment for Veterans With Hepatitis C and PTSD
The main objective of this proposal is to develop and test the efficacy of two interventions (a telehealth and face-to-face intervention) designed to improve quality of life, self-care, motivation to engage in healthcare, and…
- Conditions
- Chronic Disease, Hepatitis C, Stress Disorders, Post-Traumatic
- Trial name
- NCT00333710
- Testing
- Individual psychotherapy, Telehealth Intervention
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- US Department of Veterans Affairs
Hepatitis C
Effect of Omeprazole and Ritonavir on GSK2336805 Pharmacokinetics in Healthy Adults
This study is a Phase I open label drug interaction study to evaluate the effect of omeprazole and ritonavir on GSK2336805.
- Trial name
- NCT01458054
- Testing
- Cohort 1 (GSK2336805 60mg x 1 dose, Omeprazole 40 mg q24h x 4 days, GSK2336805 60 mg x 1 dose and Omeprazole 40 mg x 1 dose), Cohort 2 (GSK2336805 30mg x 1 dose, Ritonavir 100mg q12h x 4 days, and Ritonavir 100mg q12h x 1 dose)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Hepatitis C, HIV Infections
Leukapheresis for Research on HCV-Coinfected Patients
This study will collect quantities of white blood cells from patients infected with the hepatitis C virus (HCV) for research on the interactions between HCV and the human immunodeficiency virus (HIV) in people infected with both…
- Trial name
- NCT00076427
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hepatitis B
A Study to Compare the Immune Response and Safety Elicited by Henogen's Adjuvanted Hepatitis B Vaccine Compared to GSK Biologicals Adjuvanted Hepatitis B Vaccine in Pre-Dialysis and Dialysis Patients Who Have Not Been Exposed to Hepatitis B.
The pre-dialysis, peritoneal dialysis and haemodialysis patients would benefit from an improved hepatitis B vaccine, which will elicit stronger and faster cellular and humoral immune responses after the primary vaccination course.
- Trial name
- NCT00291941
- Testing
- Henogen HBV vaccine, FENDRIX
- Where
- 24 sites in Belgium, Czechia and 1 more
- Volunteers
- 300 people
- Sponsor
- Henogen
Pediatric Immuno-Tolerant Chronic Hepatitis B
A Study of Pegylated Interferon Alfa-2A in Combination With Lamivudine or Entecavir Compared With Untreated Control Group in Children With Hepatitis B Envelope Antigen (HBeAg)-Positive Chronic Hepatitis B (CHB) in the Immune-Tolerant Phase
This randomized, controlled, parallel group, open-label multicenter study will evaluate the efficacy and safety of a combination of pegylated interferon alfa-2A (Pegasys) plus lamivudine or entecavir compared with an untreated…
- Trial name
- NCT02263079
- Testing
- Entecavir, Lamivudine, Pegylated Interferon Alfa-2A
- Where
- 25 sites in United States, Australia and 10 more
- Volunteers
- 62 people
- Sponsor
- Hoffmann-La Roche
Hepatitis B, Hepatitis, Viral, Human
Hepatitis B Vaccine Clinical Trial
To determine the efficacy of a hepatitis vaccine in preventing hepatitis B.
- Conditions
- Hepatitis B, Hepatitis, Viral, Human, Liver Diseases
- Trial name
- NCT00000583
- Testing
- hepatitis B vaccines
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Nonalcoholic Fatty Liver Disease
Effect of Mediterranean Diet in Obese Adolescents With Nonalcoholic Fatty Liver Disease
The aim of this study was to evaluate the effects of mediterranean and low-fat diet on hepatic fat, inflammation markers and oxidative stress in adolescents with nonalcoholic fatty liver disease.
- Trial name
- NCT04845373
- Testing
- Mediterranean diet, Control diet: Low fat diet
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Gazi University
Hepatitis C
DBS TaT in Peer-assisted Telemedicine for Hepatitis C
The purpose of this study is to compare the rate of treatment initiation achieved by peer-assisted telemedicine contingent on phlebotomy (usual care) versus that achieved with a new protocol, called Dried Blood Spot Test and…
- Trial name
- NCT06409169
- Testing
- DBS TaT, Usual Care
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Oregon Health and Science University
Hepatitis C, Chronic
The No One Waits Study: Acceptability and Feasibility of Community-based Point-of-diagnosis HCV Treatment Study
Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) offers a cure to those with chronic HCV infection. For marginalized communities, linkage to care services often aren't enough to overcome barriers to accessing the…
- Trial name
- NOW (NCT03987503)
- Testing
- Epclusa (SOF/VEL), Standard of care, Fibroscan® 430 Mini Plus
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hepatitis C, Chronic
VX-950-TiDP24-C219: A Roll Over Trial for Patients in the Control Group of the C216 Study Who Received Telaprevir Placebo
The purpose of this study is to provide access to telaprevir for patients from the control group in the C216 study, who failed treatment for virologic reasons.
- Trial name
- NCT01054573
- Testing
- Telaprevir, pegylated interferon (Peg-IFN) alfa-2a, ribavirin (RBV)
- Where
- 48 sites in United States, Australia and 13 more
- Volunteers
- 90 people
- Sponsor
- Janssen Infectious Diseases BVBA
Hepatitis B, HIV
Comparative Efficacy of an Intensified Re-vaccination Scheme for Hepatitis B Virus Infection Among Patients Infected With HIV .
Hepatitis B virus infection is a common occurrence among patients with HIV. Effective vaccines are available, but there's some uncertainty regarding specific dosages, specially among those who have not responded to an initial…
- Trial name
- CORE-HIV (NCT02003703)
- Testing
- Recombinant Hepatitis B Virus Vaccine
- Where
- Chile
- Volunteers
- 107 people
- Sponsor
- Universidad de Valparaiso
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