Clinical trials: Liver Metastases of Colorectal Cancer
Liver Neoplasms, Sarcopenia
Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection
The investigators will investigate the impact of different biometric parameters (Body mass index, sarcopenia, lean muscle mass, hand-grip strength, gait speed, fat composition) on the postoperative outcomes of patients undergoing…
- Conditions
- Liver Neoplasms, Sarcopenia, Postoperative Complications
- Trial name
- NCT03630978
- Testing
- Liver resection
- Where
- Italy
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- San Camillo Hospital, Rome
Colorectal Cancer, Unresectable Liver Metastasis
Neoadjuvant FOLFOX6 + Cetuximab in Patients With Colorectal Cancer and Unresectable Liver Metastasis
An innovative therapeutic strategy to increase the complete resection rate is of utmost importance in order to enhance survival in colorectal cancer patients with unresectable liver-only metastasis.
- Trial name
- NCT00743678
- Testing
- FOLFOX6/cetuximab
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Samsung Medical Center
Colorectal Liver Metastasis (CRLM), Liver Resection
The Use of Artificial Intelligence for the Prediction of Recurrence After Resection of Colorectal Liver Metastases
Colorectal cancer is the third most common cancer worldwide and the fourth most common cause of cancer-related death. Survival is primarily determined by stage of disease and the presence of metastases.
- Conditions
- Colorectal Liver Metastasis (CRLM), Liver Resection, Hepatectomy, Liver Ablation
- Trial name
- AI-RECOLMET (NCT07385521)
- Testing
- AI-analysis
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Francesco De Cobelli
Colorectal Liver Metastases, Colorectal Cancer
The Role of Tumor-associated Macrophages in Colorectal Liver Metastases
Colorectal cancer is a major cause of mortality worldwide. Most patients develop colorectal liver metastases (CLM), and for such patients hepatectomy combined with chemotherapy may be curative.
- Conditions
- Colorectal Liver Metastases, Colorectal Cancer, Liver Metastases, Immunotherapy
- Trial name
- NCT03888638
- Testing
- Hepatectomy
- Volunteers
- 101 people
- Sponsor
- Humanitas Clinical and Research Center
Liver Metastases, Mucinous Adenocarcinoma of the Colon
Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver
This phase I trial studies the side effects and best dose of irinotecan-eluting beads in treating patients with colon or rectal cancer that has spread to the liver and does not respond to treatment with standard therapy.
- Conditions
- Liver Metastases, Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer
- Trial name
- NCT02110953
- Testing
- irinotecan-eluting beads, hepatic artery embolization
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Neoplasms Malignant, Liver Metastases
Combined Immunotherapy and Radiosurgery for Metastatic Colorectal Cancer
A single institution study to evaluate the safety and tolerability of the combination treatment of nivolumab, ipilimumab, CMP-001 and radiosurgery in patients with metastatic colorectal cancer with liver metastases.
- Trial name
- NCT03507699
- Testing
- Liver radiation therapy, Nivolumab Injection [Opdivo], Ipilimumab Injection [Yervoy]
- Where
- Israel
- Volunteers
- 19 people
- Sponsor
- Sheba Medical Center
Liver Metastasis Colon Cancer, Postoperative Complications
Effect of the Laparoscopic Approach in Reducing Postoperative Severe Complications Following Hepatectomy for Colorectal Liver Metastases
The objective of this study is to demonstrate the superiority of the laparoscopic approach over the open approach in the resection of colorectal liver metastases, by examining the reduction of postoperative complications…
- Trial name
- METALAP (NCT04163887)
- Testing
- hepatectomy
- Where
- 21 sites in France
- Volunteers
- 340 people
- Sponsor
- Institut Mutualiste Montsouris
Liver Metastases From Colorectal Cancer
Liver-First, Bowel-First, or Simultaneous Resection for Synchronous Colorectal Liver Metastases: Outcomes, Quality of Life, and Cost-Effectiveness
The goal of this observational study is to learn about treatment outcomes, quality of life, and healthcare costs in patients with colorectal cancer who have liver metastases detected at the same time as their primary tumor…
- Trial name
- OPTIMAL (NCT07564284)
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Liver Metastases
Treatment of Liver Metastases With Electrochemotherapy
The aim of the study is to evaluate toxicity and effectiveness of electrochemotherapy with bleomycin in treatment of liver metastases of colorectal cancer in clinical study phase I and II.
- Trial name
- ECTJ (NCT01264952)
- Testing
- Electrochemotherapy
- Where
- Slovenia
- Volunteers
- 16 people
- Sponsor
- Institute of Oncology Ljubljana
Liver Metastases, Colorectal Cancer
Dynamic ctDNA Detection for Colorectal Cancer Liver Metastases
Evaluating the value of dynamic monitoring of a colorectal cancer liver metastasis cohort underwent curative resection after receiving multipoint ctDNA detecting in predicting recurrence prognosis and guiding adjuvant…
- Conditions
- Liver Metastases, Colorectal Cancer, Surgery, Circulating Tumor DNA
- Trial name
- NCT06404593
- Testing
- Blood sampling
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer (CRC), Colon Cancer Liver Metastases
Injection of IP-001 Into Thermally Ablated Hepatic Tumors in Patients With Colorectal Liver Metastases
The goal of this clinical trial is to learn if a new injectable drug (IP-001), administered after standard liver tumor ablation, can help prevent cancer from returning in people (males/females, ≥18 years old) with colorectal…
- Conditions
- Colorectal Cancer (CRC), Colon Cancer Liver Metastases, Rectal Cancer, Rectal Cancer With Liver Metastases
- Trial name
- INJECTABL-3 (NCT07321847)
- Testing
- 1.0% IP-001 for Injection, a 10 mg/mL solution of IP-001 in water, 1.0% IP-001 for Injection, a 1 mg/mL solution of IP-001 in water., Microwave (thermal) tumor ablation
- Volunteers
- 717 people
- Sponsor
- Immunophotonics, Inc.
For Patients With Colorectal Cancer Liver Metastases Who Were Not Able to Curative Surgical Resection.Focused on the Treatment Effect With the Quintuple Method
Quintuple Method for Treatment of Multiple Refractory Colorectal Liver Metastases
The aim of this study is to explore the therapeutic effect of Quintuple method in the treatment of patients with multiple and refractory liver metastases from colorectal cancer.
- Trial name
- NCT05774964
- Testing
- Oxaliplatin, S1, Cetuximab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Liaoning Cancer Hospital & Institute
Colorectal Cancer
Treatment of Unresectable Colorectal Metastases by Radiofrequency Ablation Combined or Not With Resection, With or Without Neoadjuvant Chemotherapy.
The hypothesis is that radiofrequency ablation combined or not with resection may allow a local control (the liver) in patients suffering from unresectable colorectal liver metastases.
- Trial name
- ARF2003 (NCT00210106)
- Testing
- Ablathermy
- Where
- 12 sites in France
- Volunteers
- 52 people
- Sponsor
- Institut Bergonié
Colorectal Liver Metastases, Quality of Life
Quality of Life and Liver Metastases
An increasing aggressiveness in the surgical approach of colorectal liver metastases is observed. This seems only justified when, besides prolongation of survival, also the health status of patients is considered.
- Trial name
- NCT00184834
- Testing
- quality of life
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer
Combined Resection of Colorectal Metastases
This is a Phase II study of combined surgical resection for patients with both intra- and extra-hepatic metastases from colorectal cancer.
- Trial name
- CRC (NCT00606398)
- Testing
- surgical resection for patients with both intra- and extra-hepatic metastases
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Neoplasm Metastasis
Study to Evaluate a High Intensity Focused Ultrasound (HIFU) Procedure in Patient With Liver Metastases
The purpose of this study is to assess the feasibility, safety and efficacy of High Intensity Focused Ultrasound (HIFU) patients undergoing hepatectomy for colorectal liver metastases. This is a phase I/II study.
- Trial name
- HIFU (NCT01489787)
- Testing
- HIFU
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Centre Leon Berard
Secondary Malignant Neoplasm of Liver
A Trial on SBRT Versus MWA for Inoperable Colorectal Liver Metastases (CLM)
The trial is designed to perform a rigorous evaluation of efficacy and tolerability of SBRT by means of a randomised, controlled trial in patients affected by inoperable colorectal liver metastases. The chosen comparator is MWA.
- Trial name
- NCT02820194
- Testing
- Stereotactic Body Radiation Therapy, Microwave Ablation
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Istituto Clinico Humanitas
Colorectal Cancer, Liver Metastases
Hepatic Arterial Chemotherapy With Raltitrexed and Oxaliplatin Versus Standard Chemotherapy in Unresectable Liver Metastases From Colorectal Cancer After Conventional Chemotherapy Failure
Standard treatment of metastatic colorectal cancers relies on fluoropyrimidines, irinotecan alone or in association with fluoropyrimidines, oxaliplatin in association with fluoropyrimidines, bevacizumab and anti EGFR antibodies.
- Trial name
- HEARTO (NCT01348412)
- Testing
- oxaliplatin, raltitrexed, other intravenous chemotherapy drugs
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Georges Francois Leclerc
Liver Resection, Colorectal Carcinoma Liver Metastases
Safety of HRX215 in Patients After Minor and Major Liver Resection
The goal of this clinical trial is to learn if HRX215 is safe, tolerable and active in adults who have undergone liver resection due to colorectal carcinoma metastases. The objectives are: 1.
- Trial name
- NCT06638502
- Testing
- HRX215 capsules
- Where
- 14 sites in United States, France and 3 more
- Volunteers
- 80 people
- Sponsor
- HepaRegeniX GmbH
Colon Cancer Liver Metastases, Liver Neoplasms
Associating Liver Partition With Portal Vein Ligation for Staged Hepatectomy (ALPPS) vs. Two-Stage Hepatectomy (TSH) for Marginally Resectable Colorectal Liver Metastases (CRLM)
Surgical resection has offered the best option for prolonged survival in patients with colorectal liver metastases. Limiting factor for major liver resections is the size of the future liver remnant (FLR).
- Conditions
- Colon Cancer Liver Metastases, Liver Neoplasms, Liver Diseases, Secondary Malignant Neoplasm of Liver
- Trial name
- ALPPSforCRLM (NCT02758977)
- Testing
- ALPPS, TWO STAGE HEPATECTOMY
- Where
- Switzerland
- Volunteers
- 214 people
- Sponsor
- University of Zurich