Clinical trials: Liver Regeneration
Alcoholic Hepatitis
Granulocyte Colony Stimulating Factor Four Week Plus N-Acetyl Cysteine in Severe Alcoholic Hepatitis
Alcoholic hepatitis is related to very high mortality rate. About 40% of the patients died within first 6 months after the detection of the clinical syndrome.
- Trial name
- NCT05840640
- Testing
- Standard Medical Therapy, G-CSF, G-CSF and NAC
- Where
- India
- Volunteers
- 66 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Liver Disease
Effect of BCAA Supplementation on Muscle Mass, Muscle Quality and Molecular Markers of Muscle Regeneration in CLD Patients
Loss of muscle mass (sarcopenia) is a major complication in a patient with cirrhosis, impacting the disease outcome, quality of life and survival.
- Trial name
- BCAA-CLD (NCT04246918)
- Testing
- Branched Chain Amino Acid, Whey Protein concentrate powder
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis
Liver Regeneration Therapy by Intrahepatic Arterial Administration of Autologous Adipose Tissue Derived Stromal Cells
Mesenchymal stem cells have capability to differentiate into hepatocyte and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cell compared to bone marrow tissue.
- Trial name
- NCT01062750
- Testing
- adipose tissue derived stromal cells dosage
- Where
- Japan
- Volunteers
- 4 people
- Sponsor
- Kanazawa University
Hepatorenal Syndrome, Liver Regeneration
Plasma and Hemodynamic Markers During Hepatectomy
Introduction Liver resection is considered the only curative treatment option for mCRC patients without extrahepatic disease and is accepted practice.
- Trial name
- NCT01700231
- Testing
- Liver resection
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Small-For-Size Liver Syndrome, Ligation
Splenic Artery Ligation and Portocaval Shunt in Small-for-size Syndrome
Our study aimed at assessing the changes of portal vein pressure, portal vein flow and hepatic arterial flow (HAF) in liver remnants ≤ 30% of the standard liver volume by reducing portal vein overflow via ligation of the splenic…
- Conditions
- Small-For-Size Liver Syndrome, Ligation, Liver Regeneration, Splenic Artery
- Trial name
- splen ligation (NCT05459883)
- Testing
- splenic artery ligation
- Where
- Greece
- Volunteers
- 13 people
- Sponsor
- Aretaieion University Hospital
Liver Cirrhosis
Liver Regeneration Therapy Using Autologous Adipose Tissue Derived Stromal Cells
Mesenchymal stem cells have the capability to differentiate into hepatocytes and will be useful for liver regeneration. Adipose tissue is relatively enriched with mesenchymal stem cells compared to bone marrow tissue.
- Trial name
- NCT00913289
- Testing
- adipose tissue derived stromal cells
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Kanazawa University
Primary Liver Cancer, Hepatocellular Carcinoma (HCC)
The Dragon PLC Trial (DRAGON-PLC)
The goal of the DRAGON PLC clinical trial is to determine whether portal vein embolization (PVE) combined with hepatic vein embolization (HVE) improves resectability and overall survival in patients with initially unresectable…
- Conditions
- Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
- Trial name
- NCT06914648
- Testing
- Portal Vein Embolization, Hepatic Vein Embolization
- Where
- 55 sites in United States, Australia and 10 more
- Volunteers
- 358 people
- Sponsor
- Maastricht University
Acute-On-Chronic Liver Failure
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial
Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only ~2,500 performed, non-transplant options are urgently needed.
- Trial name
- NC-CHRM (NCT07131306)
- Testing
- ucMSC and Standard medical treatment, Standard medical treatment
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Bariatric Surgery Candidate, Nonalcoholic Steatohepatitis
Pathogenesis of Non-alcoholic Steatohepatitis and Liver Regeneration After Bariatric Surgery
Obesity and obesity related health problems are globally recognized as one of the major threats to public health. Bariatric surgery is the most effective and durable therapy option for obesity and the improvement of obesity…
- Conditions
- Bariatric Surgery Candidate, Nonalcoholic Steatohepatitis, Obesity
- Trial name
- NALKOSTEP (NCT02792634)
- Testing
- Sleeve-Gastrectomy, Roux en Y gastric bypass
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- RWTH Aachen University
Alcoholic Hepatitis
G-CSF Plus NAC In Severe Alcoholic Hepatitis
Alcoholic hepatitis is related to very high mortality rate. About 40% of the patients are died within first 6 months after the detection of the clinical syndrome.
- Trial name
- NCT02971306
- Testing
- standard medical therapy, G-CSF, n-Acetylcysteine
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Living Donor Liver Transplantation
The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study
Rationale: Living donor liver transplantation (LDLT) offers a promising solution to the organ shortage. During living liver donation, a substantial portion of the donor's liver is resected.
- Trial name
- LRLDLT (NCT07329296)
- Testing
- Living liver donation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Cirrhosis, Hepatitis C
Adult-to-Adult Living Donor Liver Transplantation Study
There are two principal purposes of this study: 1) to determine whether it is more beneficial for a liver transplant recipient candidate to pursue a living donor liver transplant (LDLT) or wait for a deceased donor liver…
- Conditions
- Cirrhosis, Hepatitis C, Hepatocellular Carcinoma
- Trial name
- A2ALL-1 (NCT00096733)
- Where
- 9 sites in United States
- Volunteers
- 2,470 people
- Sponsor
- Arbor Research Collaborative for Health
HIV Infection, AIDS
HIV Liver Regeneration Project for HIV Patients With Cirrhosis by Autologous Bone Marrow Transplantation
An international investigation to evaluate if, and if so how long, autologous bone marrow hematopoietic stem cell transplantation can safely restore liver functions for HIV infected patients who have decompensated liver cirrhosis.
- Conditions
- HIV Infection, AIDS, Cirrhosis
- Trial name
- HIV-ABMi (NCT01309594)
- Testing
- Hematopoietic stem cell transplantation
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- National Center for Global Health and Medicine, Japan
Liver Dysfunction, Liver Metastasis Colon Cancer
Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy.
- Conditions
- Liver Dysfunction, Liver Metastasis Colon Cancer, Liver Regeneration
- Trial name
- NCT06126419
- Testing
- High-Dose Insulin Therapy
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Liver Failure, Acute, Liver Failure, Acute on Chronic
HEpatic Regeneration With COupled Plasma Filtration and Adsorption for Liver Extracorporeal Detoxification
CPFA is currently used in the treatment of severe sepsis with the intention of removing the proinflammatory mediators from the systemic circulation.
- Trial name
- HERCOLE (NCT03312036)
- Testing
- Coupled plasma filtration and adsorption (CPFA)
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Colorectal Liver Metastases
Impact of Preoperative Chemotherapy on Complications and Regeneration After Resection of Colorectal Liver Metastases
The objective of this study is to evaluate for the first time not only the impact of neoadjuvant chemotherapy on clinical outcome, but also on liver regeneration after liver resection.
- Trial name
- NCT00779272
- Where
- Switzerland
- Volunteers
- 184 people
- Sponsor
- University of Zurich
Liver Regeneration
Study of the Protective Effect of Mechanism of Pentoxyfilline After Major Liver Resection Under Inflow Occlusion (Pringle Manoeuvre)
The investigators hypothecate that pentoxyfilline increase significantly the liver regeneration and reduces significantly ischemia and reperfusion (I/R) injury in major liver using aspartate aminotransferase (AST) and alanine…
- Trial name
- NCT00957619
- Testing
- pentoxyfilline
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Liver Cirrhosis
Evaluation of Liver Regeneration With Autologous Peripheral Stem Cells
For patient with liver cirrhosis who need to right or extended right hepatectomy, we will treat with autologous peripheral stem cells transplantation to facilitate liver regeneration.
- Trial name
- NCT01108380
- Testing
- Plasma pheresis, Right portal vein embolization
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Liver Diseases, Liver Cancer
Liver Regeneration
The liver is the only visceral organ with a tremendous capacity to regenerate. We don't yet understand how normal liver regeneration occurs (on a molecular level) or how to distinguish between normal and "abnormal"/neoplastic…
- Trial name
- NCT03396705
- Testing
- Liver Biopsy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Liver Cancer
Bone Marrow Derived Adult Liver Stem Cell Recruitment After Major Liver Resections: Correlation With Liver Regeneration and Hepatic Function
The results of this study may or may not establish useful baseline data, which will help us understand how bone marrow derived adult liver stem cells behave in normal healthy adults/volunteers (the control group), and in patients…
- Trial name
- NCT00605800
- Testing
- blood drawn
- Volunteers
- healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center