Clinical trials: Liver Resection
HepatoCellular Carcinoma
Radiotherapy in Hepatocellular Carcinomas After Hepatectomy With Narrow Margin (<1 cm) or Portal Vein Thrombosis
Hepatocellular carcinoma (HCC) is one of ten leading cancer types worldwide and also in Asia, but the five-year relative survival rate is relatively quite low1-3.
- Trial name
- RHCC (NCT02309788)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Liver Regeneration, Ursodeoxycholic Acid
Effect of Ursodeoxycholic Acid Supplementation on Liver Regeneration on Right Lobe Donor Hepatectomy
The goal of this open label randomized trial is to understand the role of oral ursodeoxycholic acid(UDCA) supplementation in the liver regeneration (in terms of liver function and anatomical growth) following right lobe donor…
- Conditions
- Liver Regeneration, Ursodeoxycholic Acid, Partial Liver Resection
- Trial name
- NCT06091787
- Testing
- Ursodeoxycholic acid, Standard Medical Treatment
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cancer, Esophageal Cancer
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
The investigators hypothesize that abnormalities in thromboelastography (TEG) parameters in patients with liver, pancreas, biliary, esophageal, colorectal, and lung adenocarcinoma can serve as biomarkers for oncologic disease…
- Conditions
- Liver Cancer, Esophageal Cancer, Colorectal Cancer, Lung Adenocarcinoma
- Trial name
- TEG (NCT05517811)
- Testing
- TEG indices
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver
Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC
The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage.
- Trial name
- NCT01608945
- Testing
- Hydrocortisone sodium succinate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Eastern Hepatobiliary Surgery Hospital
Liver Cancer
Effect of Smoked Plum and Chewing Gum on Postoperative Bowel Function Following Hepatic Resection
Every patient undergoing surgery in the abdomen, such as hepatic resection, will experience temporary paralysis of bowel function.
- Trial name
- SP/GC-HCC (NCT02649153)
- Testing
- smoked plum, gum chewing
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Carcinoma, Hepatocellular
Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or Portal Vein Occlusion in Treating Patients With Liver Cancer
This randomized phase II trial compares how well associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) or portal vein occlusion (PVO) works in treating patients with liver cancer.
- Trial name
- ALPPS (NCT01722175)
- Testing
- ALPPS surgery, PVO surgery
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Donor Site Complication, Delirium
s100β, NSE n GFAP in Living Donor Hepatectomy and Delirium
The post-operative delirium picture is a serious and common complication seen after any major surgery, including hepatic resection.
- Conditions
- Donor Site Complication, Delirium, Uremic Encephalopathy, Neurologic Manifestations
- Trial name
- NCT04422925
- Testing
- Living Donor Hepatectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Liver Regeneration, Liver Metastases
Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastases
Liver is special organ, which can regenerate. On that ability there are many treatment modalities, where liver resection is performed, especially in cancer patients with liver metastases.
- Trial name
- VULSK-Hep (NCT04178759)
- Testing
- Liver resection
- Where
- Lithuania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Liver Cancer
Association Between Autologous Transfusion and Recurrence-free Survival in Patients With HCC After Resection
This prospective non-randomized controlled trial aims to determine whether autotransfusion of red blood cells salvaged before liver resection is associated with the recurrence-free survival in patients with hepatocellular…
- Trial name
- AT/HCC (NCT02654028)
- Testing
- Autotransfusion, Control group
- Where
- China
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Hepatocellular Carcinoma, Hypoproteinemia
Albumin for Hepatocellular Carcinoma
The rate of liver cirrhosis is about 40% to 75% among patients with hepatocellular carcinoma (HCC). Therefore, many patients with HCC were with low serum albumin before and after (especially) hepatic resection.
- Trial name
- NCT03974074
- Testing
- Albumin infusion
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Central Venous Pressure, Hepatectomy
Preoperative Sildenafil Administration for Hepatectomy
Hepatectomy is an important treatment for liver diseases, and bleeding is one of the most common complications during dissection of the liver parenchyma.
- Conditions
- Central Venous Pressure, Hepatectomy, Hemodynamics Instability, Sildenafil
- Trial name
- NCT06237751
- Testing
- Sildenafil 100 MG
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Liver Insufficiency
Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors
The PI will study metabolism during liver regeneration in living liver donors
- Trial name
- NCT01922323
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Hepatobiliary Disease
Usefulness of BiClamp Forceps for Liver Resection: A Randomized Clinical Trial
The purpose of this study is to compare short-term and long-term efficacy of BiClamp forceps hepatectomy and clamp-crushing technique for parenchymal transection during elective hepatic resection.
- Trial name
- NCT02197481
- Testing
- Clamp-Crushing technique, BiClamp forceps
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Anhui Medical University
Hepatocellular Carcinoma
Hepatectomy Combined With Camrelizumab and Apatinib in CNLC Stage IIIb HCC
This study intends to prospectively enroll CNLC stage IIIb HCC cases with extrahepatic metastasis and intrahepatic lesions that are expected to be radical resected in several domestic clinical centers, and observe the OS and ORR…
- Trial name
- NCT05062837
- Testing
- Hepatectomy Combined With Camrelizumab and Apatinib
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Hepatocellular Carcinoma
Clinical Study Examining the Safety and Efficacy of Doxorubicin Drug Eluting Microspheres Transarterial Embolization in the Setting of Hepatocellular Carcinoma (HCC)
The study is designed to determine whether loading doxorubicin (a type of chemotherapy), when loaded onto a drug eluting microsphere will result in increased destruction of a tumor.
- Trial name
- NCT01116635
- Testing
- doxorubicin, superabsorbent polymer microspheres, embolotherapy
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Liver Neoplasms, Sarcopenia
Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection
The investigators will investigate the impact of different biometric parameters (Body mass index, sarcopenia, lean muscle mass, hand-grip strength, gait speed, fat composition) on the postoperative outcomes of patients undergoing…
- Conditions
- Liver Neoplasms, Sarcopenia, Postoperative Complications
- Trial name
- NCT03630978
- Testing
- Liver resection
- Where
- Italy
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- San Camillo Hospital, Rome
Hepatocellular Carcinoma
Simo Decoction and Gum Chewing for Bowel Activity
Abdominal surgery, including hepatic resection for hepatocellular carcinoma (HCC), is inevitably followed by an episode of gastrointestinal hypomotility.
- Trial name
- SD/GC-HCC (NCT02438436)
- Testing
- simo decoction, gum chewing
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Guangxi Medical University
Laparoscopic Hepatectomy
The Effect of Remimazolam Versus Propofol on Postoperative Extubation Time
This clinical trial aims to help us understand how two drugs, Propofol and Remazoloam, affect when researchers remove a Participants' breathing tube after liver surgery (laparoscopic liver resection).The main research questions…
- Trial name
- NCT07611344
- Testing
- Remimazolam, propofol
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Xuyu Zhang
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich