Clinical trials: Liver Transplant; Complications
Cytomegalovirus, Organ Transplant
Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)
This study is being done to find out if administering CytoGam® after the end of standardly prescribed preventive antiviral treatment can help transplant recipients with a high risk for developing late CMV disease after a liver…
- Conditions
- Cytomegalovirus, Organ Transplant, Kidney Transplant; Complications, Liver Transplant Complications
- Trial name
- SHIELD (NCT06958796)
- Testing
- Cytomegalovirus Immune Globulin Intravenous (Human) monthly for three months
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Camille N. Kotton, MD
Renal Insufficiency
Safety Use of ATeGe in Liver Transplant Recipients With Pre-transplant Renal Dysfunction
Renal dysfunction in the context of liver transplantation is a major issue, with difficult patients' management and determining a worsened prognosis.
- Trial name
- ATG_HVH (NCT01453218)
- Testing
- ATeGe-Fresenius
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Vall d'Hebron
Kidney Failure, Hepatitis C
HCV + to HCV - Kidney Transplant
This is a single center study characterizing the experience of administration of 8 weeks of pan-genotypic DAA therapy in kidney transplantation to prevent the transmission of hepatitis C virus infection from an HCV-positive donor…
- Trial name
- NCT04320290
- Testing
- Direct Acting Antivirals
- Sponsor
- Massachusetts General Hospital
Liver Transplant
Biliary Anastomosis in Living Donor Liver Transplant With Amniotic Tissue
The goal of this single armed, non-randomized, pilot study is to demonstrate that placental tissue grafts are safe in living donor liver transplant and assess their impact on biliary outcomes in adults.
- Trial name
- NCT07102550
- Testing
- MiMedx AmnioFix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Jaekeun Kim
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Liver Transplant; Complications, Vitamin D Deficiency
Relationship Between Serum Vitamin D and Outcomes of Liver Transplantation in Cirrhotic Patients Undergoing Liver Transplantation and Effects of Vitamin D Supplementation in Post-transplant Period
The study population is patients with liver cirrhosis undergoing liver transplantation; In this study, the sample will be selected from cirrhosis patients undergoing liver transplantation in Taleghani (Tehran), Imam Khomeini…
- Trial name
- NCT05568836
- Testing
- vitamin D supplementation, control
- Volunteers
- 42 people
- Sponsor
- National Nutrition and Food Technology Institute
Postoperative Residual Curarization, Liver Transplantation
Sugammadex/Neostigmine and Liver Transplantation
Cirrhotic patients undergoing liver transplantation are at very high risk of post operative complication such as post-operative residual curarization.
- Trial name
- NCT02697929
- Testing
- sugammadex, Neostigmine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliera S. Maria della Misericordia
Liver Transplant; Complications
Perioperative Hemostasis Management in Liver Transplantation
Liver transplantation (LT) is a surgery with risk of bleeding. Several risk factors have been identified: complex dissection, portal hypertension, history of ascites fluid infections, history of surgical procedures, pre-existing…
- Trial name
- HEMOTRANSPLANT (NCT06257407)
- Where
- 16 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Société Française d'Anesthésie et de Réanimation
Evidence of Liver Transplantation
Study to Establish Whether the Use of T-Tube in Bile Duct Anastomosis in Liver Transplantation Decreases Morbidity
The purpose of this study was to compare the incidence and severity of biliary complications due to liver transplantation after choledochocholedochostomy with or without a T-tube.
- Trial name
- NCT01546064
- Testing
- Choledocho-choledochostomy with T-tube, Choledocho-choledochostomy without T-tube
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario La Fe
Tissue Donors, Liver Transplantation
The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy
Liver transplantation is the gold standard treatment for patients with end-stage liver disease. Despite its outstanding success, liver transplantation still entails certain complications including ischemia-reperfusion injury.
- Conditions
- Tissue Donors, Liver Transplantation, Ischemia Reperfusion Injury
- Trial name
- NCT03386435
- Testing
- remote ischemic preconditioning
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Asan Medical Center
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Liver Transplant; Complications, Neurologic Complication
Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation
Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation.
- Conditions
- Liver Transplant; Complications, Neurologic Complication, Postoperative Complications
- Trial name
- NCT04188717
- Volunteers
- 253 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Diseases, Kidney Diseases
Clinical Trial of New Hypothermic Oxygenated Perfusion System Versus Static Cold Storage
With the present study the investigators will evaluate the benefit of end-ischemic HOPE on ECD grafts (livers and kidneys) as compared to SCS.
- Trial name
- NCT03837197
- Testing
- Kidney-Hypothermic oxygenated, Liver-Hypothermic oxygenated
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Bologna
Hepatitis C, Renal Insufficiency, Chronic
HCV Treatment Immune Response With Grazoprevir/Elbasvir Before or After Renal Transplant
The purpose of this study is to determine whether patients treated for chronic hepatitis C (HCV) with zepatier (grazoprevir/elbasvir) prior to kidney transplant will have a stronger immune response compared to patients treated…
- Conditions
- Hepatitis C, Renal Insufficiency, Chronic, Disorder of Transplanted Kidney
- Trial name
- NCT02902120
- Testing
- Post-transplant Grazoprevir and Elbasvir
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Liver Cirrhosis
Implications of Fecal Microbiota Transplantation in Modulating the Effects of Liver Cirrhosis
The study aims to investigate the beneficial effects of fecal transplantation in patients diagnosed with liver cirrhosis (regardless of etiology).
- Trial name
- NCT06478602
- Testing
- Fecal microbiota transplantation
- Where
- Romania
- Volunteers
- 19 people
- Sponsor
- Cristian Ichim
Covid19, Kidney Transplant; Complications
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies
The Covid-19 Serum Study is a prospective case-control study in 1. kidney or liver transplanted patients being hospitalized due to an infection with Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) after…
- Conditions
- Covid19, Kidney Transplant; Complications, Kidney Transplant Failure and Rejection, Liver Transplant; Complications
- Trial name
- NCT04694573
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Heidelberg University
End Stage Renal Disease, End Stage Liver Disease
Transplant Patient Registry of Liver, Kidney and/or Pancreas
This is a registry of data collected from patient records, both of those who have a condition which may require transplantation and those who have undergone transplantation of the liver, kidney and/or pancreas.
- Trial name
- NCT00238693
- Where
- United States
- Volunteers
- 13,767 people
- Sponsor
- Virginia Commonwealth University
Late Complication From Kidney Transplant, Complication of Transplanted Liver
Immunogenicity and Safety of Human Papilloma Virus Vaccine in Solid Organ Transplant Recipients
The human papilloma virus (HPV) is known to be an important cause of cervical and anal cancers. Studies on patients who have received a solid organ transplant (such as a liver or kidney transplant) have suggested the risk of…
- Conditions
- Late Complication From Kidney Transplant, Complication of Transplanted Liver, Human Papillomavirus-Related Carcinoma
- Trial name
- NCT02624349
- Testing
- Quadravalent human papillomavirus vaccine
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- The Hospital for Sick Children
Liver Transplant; Complications
Contributions of Transesophageal Echocardiography in Liver Transplant Surgery
The goal of this study is to describe the safety and impact of transesophageal echocardiography in instability episodes during liver transplantation, especially during reperfusion stage.
- Trial name
- NCT05175534
- Testing
- monitoring
- Where
- 2 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Liver Transplant; Complications, AKI - Acute Kidney Injury
The Efficacy of Intravenous Amino Acids in Reducing the Occurrence of AKI After Live Donor Liver Transplant
This prospective, open-label, randomized controlled trial aims to evaluate the efficacy of intravenous amino acid infusion in reducing AKI after LDLT.
- Trial name
- NCT07132697
- Testing
- L-Amino acid mixture, Standard of care
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India