Clinical trials: Liver Transplant; Complications
Liver Transplant; Complications, Surgical Injury
Magnetic Spiderman for Preparation of Liver Donation
Due to many vascular branches on the supra-hepatic vena cava (SHVC) and infra-hepatic vena cava (IHVC), in the whole procedures of preparation of liver donation, preparation of hepatic vena cava (HVC) is the most key and…
- Trial name
- MSPLD (NCT04182256)
- Testing
- MS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cirrhosis, Liver, Sarcopenia
Body Composition Changes After TIPS and Associated Clinical Outcomes
The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients…
- Trial name
- NCT05420753
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Oregon Health and Science University
Liver Diseases, Liver Cirrhosis
Intraoperative Phlebotomies and Bleeding in Liver Transplantation
Liver transplantation are surgeries associated with important bleeding and often require perioperative red blood cell (RBC) transfusions.
- Conditions
- Liver Diseases, Liver Cirrhosis, Surgery, Surgery--Complications
- Trial name
- TOF_PHLEBO (NCT04826666)
- Where
- Canada
- Volunteers
- 679 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Immune Tolerance, Immunosuppression
Efficacy and Safety of Immunosuppressive Withdrawal After Pediatric Liver Transplantation
The goal of this clinical trial is to learn about the efficacy and safety of immunosuppressive withdrawal in pediatric liver transplant recipients.
- Conditions
- Immune Tolerance, Immunosuppression, Liver Transplant; Complications
- Trial name
- NCT06147375
- Testing
- Tacrolimus or Cyclosporine A
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Wei Gao
Liver Transplant; Complications, HLA Antigens
The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation
Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates…
- Trial name
- NCT04885582
- Testing
- HLA antigen results
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Complication, Postoperative, Regeneration Liver
Randomized Controlled Trial to Study the Outcome of Intravenous Phosphate Supplementation in Live Donors Undergoing Hepatectomy for Living Donor Liver Transplantation (LDLT)
In this study, we aim to analyse the effect of phosphate supplementation on donors undergoing partial hepatectomy for LDLT. In Group A, we are going to supplement phosphate in donors postoperatively from day 1 to day 5.
- Trial name
- NCT04026438
- Testing
- Potassium Phosphate Injection
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Kidney Transplant; Complications, Liver Transplant; Complications
Project LIFT - Promoting Healthy Behavior Through a Wearable Fitness Device and Financial Incentives
Project LIFT is a randomized, controlled trial that tests the effectiveness of a remotely-monitored, home-based exercise program utilizing wearable fitness trackers to monitor steps taken per day, health engagement questions, and…
- Conditions
- Kidney Transplant; Complications, Liver Transplant; Complications, Obesity
- Trial name
- LIFT (NCT03221465)
- Testing
- Self-monitoring of physical activity with incentives, Usual care and self-monitoring of physical activity
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Evidence of Liver Transplantation
Study to Establish Whether the Use of T-Tube in Bile Duct Anastomosis in Liver Transplantation Decreases Morbidity
The purpose of this study was to compare the incidence and severity of biliary complications due to liver transplantation after choledochocholedochostomy with or without a T-tube.
- Trial name
- NCT01546064
- Testing
- Choledocho-choledochostomy with T-tube, Choledocho-choledochostomy without T-tube
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario La Fe
Complication of Transplanted Liver
Genetic Predisposition-Chronic Nephrotoxicity From CI-Liver Transplant Recipients-Potential Correlation-Urinary Biomarkers
The purpose of this study is to determine the relationship between genomic variants of components of the renin-angiotensin system and the development of kidney problems due to Calcineurin-inhibitors post liver transplant.Also the…
- Trial name
- NCT00857844
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Northwestern University
HHV8, HHV8 Infection
HHV8 and Solid Organ Transplantation
Solid organ transplant candidates will undergo serological screening for HHV8 at time of listing and transplantation. In the event of a recipient/donor mismatch R-/D+ or in the presence of a seropositive recipient (R+), blood…
- Conditions
- HHV8, HHV8 Infection, HHV8-Related Malignant Neoplasm, Kaposi Sarcoma
- Trial name
- NCT05081141
- Testing
- Diagnostic test for HHV8 exposure
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Liver Failure
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant
The purpose of this study is evaluate the medication vasopressin for its ability to preserve kidney function in patients undergoing liver transplantation.
- Trial name
- NCT00886262
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cancer
High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill…
- Trial name
- NCT00002854
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- City of Hope Medical Center
Liver Failure, Liver Transplant; Complications
Telemedicine Based Remote Home Monitoring After Liver Transplantation
A significant opportunity exists to involve patients and their caregivers in more effective perioperative care and transition to home for transplant patients.
- Trial name
- TelehealthOLT (NCT03878329)
- Testing
- remote home monitoring
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Liver Transplant; Complications
Predictive Factors for Massive Transfusion During Liver Transplantation
Liver transplantation (LT) is the treatment of choice for patients with end-stage liver disease (1). LT is often associated with severe intraoperative blood loss and the literature has had a great interest in clarifying the…
- Trial name
- TRADIFEG (NCT05763446)
- Where
- 2 sites in Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Liver Transplant, Complications, Biliary Anastomotic Stenosis
Biodegradable Stents in Liver Transplant RecipIents for Treatment of Biliary Anastomotic Strictures
Biliary complications after liver transplantation (LT) remain common and are associated with higher morbidity in liver transplant recipients and liver graft failure.
- Conditions
- Liver Transplant, Complications, Biliary Anastomotic Stenosis, Endoscopic Retrograde Cholangiopancreatography
- Trial name
- BRILLIANT (NCT06716541)
- Testing
- ERCP implantation of a biodegradable stent, ERCP implantation of plastic stents
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Diabetes, Liver Transplant; Complications
Optimal A1c Control in Post Liver or Combined Liver and Kidney Transplant Recipients Who Have Diabetes Mellitus
Major cardiovascular events are greatest in liver transplant recipients with sustained post-transplantation diabetes1. However, the optimal A1c target after transplantation has not been studied.
- Conditions
- Diabetes, Liver Transplant; Complications, Kidney Transplant Failure
- Trial name
- NCT04216303
- Testing
- hemoglobin A1c
- Where
- United States
- Sponsor
- Methodist Health System
Liver Transplant; Complications
Outcome Analysis of Aspirin in Liver Transplantation
In the experimental setting inhibition of platelet activation was able to reduce immune-mediated necroinflammatory liver disease and consecutively hepatocellular carcinoma development.
- Trial name
- NCT04327427
- Testing
- Aspirin
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- University of Zurich
Liver Transplant; Complications
Left Lobe Versus Right Lobe in Adult Living Donor Liver Transplantation in Borderline GRWR
a prospective cohort study comparing outcomes of left lobe and right lobe adult living donor liver transplantation
- Trial name
- LDLT (NCT06542913)
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Immune Tolerance, Liver Transplant; Complications
Immune Tolerance After Pediatric Liver Transplantation
Immunosuppressive (IS) agents are effective treatment to avoid acute or chronic rejection after pediatric liver transplantation.
- Trial name
- NCT05501301
- Testing
- IS weaning off
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital