Clinical trials: Liver Transplant Recipients
Patients Cannulated With Both PICC and CICC., The Rapidly Fluctuating Hemodynamics During LT.
Comparison of Central Venous Pressures (CVPs) Measured From Peripherally Inserted Central Catheters (PICC) and CICC in Liver Transplantation Recipients
Background: Central venous pressure (CVP) monitoring from the peripherally inserted central venous catheter (PICC) has not often been used because of the higher inherent resistance of the PICC due to its longer length and…
- Trial name
- PICC (NCT00988871)
- Testing
- PICC, CICC
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- National Cancer Center, Korea
De Novo Cancer, Liver Transplant Disorder
Early Detection of de Novo Cancer in Liver Transplant Recipients
Background The risk of cancer in liver transplant recipients is twice the cancer risk in the general population and de novo cancers are one of the leading causes of death after liver transplantation.
- Trial name
- DETECT (NCT05492617)
- Volunteers
- 3,628 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hepatitis C Infection
Study of Hepatitis C Virus (HCV) Entry Inhibitor in Liver Transplant Recipients With HCV Infection
This study will test the safety and tolerability of HCV Entry Inhibitor ITX 5061 in Liver Transplant Recipients with Hepatitis C infection.
- Trial name
- NCT01560468
- Testing
- ITX 5061
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Schiano, Thomas D., MD
Hepatitis C
Hepatitis C Positive Donor Into Hepatitis C Negative Recipients
Despite many efforts to increase the size of the donor pool, there is a large and growing disparity between the number of donor kidneys and livers available for transplantation and the number of patients on the transplant waiting…
- Trial name
- NCT03702218
- Testing
- Direct Acting Antivirals
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Transplantation Infection, Kidney Transplant; Complications
Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients
This is a pilot study designed to investigate the alterations in the gut microbiome that occur during the course of kidney transplantation, liver transplantation, allogeneic hematopoietic stem cells and mesenchymal stem cells…
- Conditions
- Transplantation Infection, Kidney Transplant; Complications, Stem Cell Transplant Complications, Liver Transplant; Complications
- Trial name
- NCT04281797
- Testing
- Intestinal microbiome new generation sequencing
- Where
- Belarus
- Volunteers
- 90 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Liver Transplant, Hepatitis C
Safety and Effectiveness Using Pegasys and Copegus in Recipients of Liver Transplantation With Hepatitis C
The study is being done to study the impact of prophylactic administration of antiviral therapy as compared to initiation of antiviral therapy at the time of clinical recurrence of hepatitis C infection in liver transplant…
- Trial name
- NCT00275548
- Testing
- Pegasys, Copegus
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
End Stage Liver Disease
Psychosocial Risks in Liver Transplant Recipients
A retrospective chart review in which the information in the standard psychosocial evaluations done pre-transplant for liver transplant recipients will be coded, recorded, and correlated with posttransplant outcomes of the same…
- Trial name
- NCT02826460
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Ischemia Re-perfusion Injury
Omega 3 Lipid Emulsions and Liver Transplantation
The study Aims to investigate the possible beneficial impact of peri-operative or post-operative administration of Omega 3 enriched lipid emulsions on recipients for living donor liver transplantation.
- Trial name
- OTLT (NCT01957943)
- Testing
- SMOFLipid, equivalent volume of 10% glucose solution
- Where
- Egypt
- Volunteers
- 114 people
- Sponsor
- Mansoura University
Major Adverse Cardiovascular Events, Liver Transplantation
Preoperative Statin Use and Major Adverse Cardiovascular Events in Liver Transplant Recipients
The goal of this multicenter observational study is to determine whether preoperative statin use reduces major adverse cardiovascular events or other complications after liver transplantation.
- Trial name
- NCT07089589
- Testing
- Preoperative Statin Use
- Where
- South Korea
- Volunteers
- 6,898 people
- Sponsor
- Asan Medical Center
Liver Transplant; Complications, Liver Diseases
Mean Systemic Filling Pressure Trends in Liver Transplant Recipients
Patients with end stage liver disease undergoing liver transplantation have varying degrees of intraoperative haemodynamic unstability during various phases of transplantation.
- Conditions
- Liver Transplant; Complications, Liver Diseases, Hemodynamic Instability
- Trial name
- NCT04462874
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Prophylaxis Against Liver Transplant Rejection
Bioavailability and Practicability of Envarsus Versus Advagraf in Liver Transplant Recipients
Trial participants are randomised within 14 days after liver transplantation surgery in a 1:1 ratio to two alternative treatment arms containing either Envarsus® (test arm) or Advagraf® (comparator arm) as first-line calcineurin…
- Trial name
- NCT04720326
- Testing
- Tacrolimus Pill, Tacrolimus capsule
- Where
- 15 sites in Germany
- Volunteers
- 268 people
- Sponsor
- Edward Geissler
HBV, Kidney Transplantation
Viral Immunity in Solid Organ Transplant Recipients: Monitoring Of The Response To Hepatitis B Booster Vaccination
Solid Organ Transplantation (SOT) is made possible by the use of a lifelong immunosuppressive treatment. This treatment limits the response of the immune system, enabling long-term survival of the transplanted organ, but also…
- Conditions
- HBV, Kidney Transplantation, Liver Transplantation
- Trial name
- VITAMIN (NCT06307808)
- Testing
- Tacrolimus, Belatacept
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Grenoble
Liver Transplantation
Effect of Cyclosporine A Versus Tacrolimus on Response to Antiviral Therapy After Hepatitis C Genotype -4 Recurrence Post Liver Transplantation
Background and Aim: The immunosuppression influence on the response to antiviral therapy (AVT) for recurrent hepatitis C virus (HCV) infection in liver transplant (LT) recipients remains controversial, especially for the rarely…
- Trial name
- NCT03665766
- Testing
- Cycloserine,Tacrolimus
- Volunteers
- 126 people
- Sponsor
- Ain Shams University
Liver Transplantation
A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant Recipients
The aims of the study was to evaluate the safety and efficacy of early introduction one month post-transplantation of everolimus associated to EC-MPS with tacrolimus discontinuation in de novo liver transplant recipients and to…
- Trial name
- SIMCER (NCT01625377)
- Testing
- tacrolimus, everolimus, Basiliximab
- Where
- 14 sites in France
- Volunteers
- 188 people
- Sponsor
- Novartis Pharmaceuticals
Polyomavirus Infections, BK Viremia
Prevalence of BK Viremia in Simultaneous Liver-Kidney Transplant
The human BK polyomavirus is a significant risk factor for renal transplant dysfunction and allograft loss. The prevalence of BK viremia (BKV) following kidney transplantation is estimated to be 10-20%.
- Conditions
- Polyomavirus Infections, BK Viremia, Liver Transplant Infection, Kidney Transplant Infection
- Trial name
- NCT05224583
- Testing
- Simultaneous Liver-Kidney Transplant
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Methodist Health System
End Stage Liver Disease, Impaired Renal Function
CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment
Background: Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors.
- Trial name
- PATRON07 (NCT00604357)
- Testing
- anti-CD 25 mAb, Sirolimus, MMF
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- University of Regensburg
Transplant, Liver
Spironolactone After Liver Transplant
To study spironolactone to prevent calcineurin inhibitor (CNI) kidney injury.
- Trial name
- NCT02883400
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Breathing, Mouth, Muscle Relaxation
Comparison of Breathing Yoga and Progressive Muscle Relaxation Techniques After Transplantation
The study aims to compare the effectiveness of breathing yoga and progressive muscle relaxation techniques in relieving pain, respiratory complications and kinesiophobia in liver transplant recipients.
- Conditions
- Breathing, Mouth, Muscle Relaxation, Pain, Postoperative, Kinesiophobia
- Trial name
- NCT07066384
- Testing
- breathing yoga, PMRTs-Progressive Muscle Relaxation Techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people
- Sponsor
- Bitlis Eren University
Liver Transplantation
Phase 3b Study to Evaluate Advagraf in Combination With Mycophenolate Mofetil and Basiliximab in Liver Transplantation
Comparison of 3 dosing regimens of Advagraf to determine if there is a dosing regimen which may have the potential to cause fewer kidney problems.
- Trial name
- DIAMOND (NCT01011205)
- Testing
- Advagraf, Mycophenolate Mofetil, Basiliximab
- Where
- 72 sites in Argentina, Austria and 21 more
- Volunteers
- 893 people
- Sponsor
- Astellas Pharma Inc
Liver Transplanatation, Postoperative Complication
Avatrombopag for Severe Thrombocytopenia After Liver Transplantation: A Retrospective Cohort Study
Severe post-transplantation thrombocytopenia (platelet count <30×10⁹/L) occurs frequently after liver transplantation (LT) and is associated with increased bleeding risk, allograft dysfunction, and transfusion-related…
- Conditions
- Liver Transplanatation, Postoperative Complication, Severe Thrombocytopenia
- Trial name
- NCT07600905
- Testing
- Avatrombopag 20 mg Oral Tablet
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Shanghai Zhongshan Hospital