Clinical trials: Liver Transplant Surgery
Liver Diseases, Liver Transplantation
Hepatic and Systemic Hemodynamic Modeling During Liver Surgery
" Despite the medical and surgical progress of the last two decades, the selection of candidates for liver surgery remains based on old principles and insufficiently sensitive to fine-tune the gesture to patient-specific…
- Trial name
- LSM (NCT05339984)
- Testing
- Partial hepatectomy (open approach), liver transplantation, Portal vein embolization
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Transplant Surgery
Epidural vs. Wound Catheter Following Liver Resection
Good postoperative pain control after any major surgery allows early mobilization, minimises postoperative complications and reduces patient distress. Multiple different methods of delivering analgesia have been described.
- Trial name
- NCT03638401
- Testing
- This arm will received perioperative transversus abdominis plane (TAP) block followed by continuous infusion of local anaestheic by wound catheters and an IV morphine PCA.
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Liver Transplantation, Surgical Wound Infection
Glycemic Control and Surgical Site Infection Incidence Among Liver Transplantation Recipients
Context: The hyperglycemia is an important independent risk factor for the Surgical Site Infection (SSI) development among liver transplantation recipients.
- Trial name
- NCT03474666
- Testing
- Strict Glycemic Control Group, Standard Glycemic Control Group
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Ramon Oliveira
Biliary Stricture
Fully Covered Self-expandable Metal Stents (FCMS) in Benign Biliary Strictures
Endoscopic treatment of benign biliary strictures can be challenging. Balloon dilation and/or plastic stent placement are currently the most popular techniques.
- Trial name
- NCT02105181
- Testing
- Placement of a FCMS in the biliary tract of the patients
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Société Française d'Endoscopie Digestive
Obesity, Weight Loss
Bariatric Embolization of Arteries in Obese Patients With HCC to Allow Salvage Liver Transplantation
Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor and has a grave prognosis. Obesity is an epidemic in the US.Patients with HCC and obesity are not candidates for liver transplantation, depriving…
- Conditions
- Obesity, Weight Loss, Body Weight, Hepatocellular Carcinoma
- Trial name
- NCT02935478
- Testing
- Embospheres Microspheres
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Louis University
Liver Failure, Acute Kidney Injury
Continuous Renal Replacement Therapy (CRRT) in Surgery Room During Orthotopic Liver Transplantation (OLT)
The study is interventional, non-pharmacological, single-center. The aim of this study is to test the possible added value of CRRT in the surgery room during liver transplantation, compared to the investigators center current…
- Conditions
- Liver Failure, Acute Kidney Injury, Kidney Disease, Chronic
- Trial name
- CRRT-OLT (NCT06844435)
- Testing
- continuous renal replacement therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Impaired Oxygen Delivery, Transplant; Failure, Liver
Non-Invasive Measurement of SjvO2 Using Near Infrared Spectroscopy in Patients Undergoing Liver Transplantation Surgery
Mixed venous oxygen saturation (SvO2) is an important parameter in the management of patient during liver transplantation surgery especially during portal vein clamping.
- Trial name
- NCT04778150
- Testing
- VO 100 medical device from Mespere LifeSciences
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Adult Hepatocellular Carcinoma, Resectable Hepatocellular Carcinoma
18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
This clinical trial studies fluorine F 18 L-glutamate derivative BAY94-9392 (18F-FSPG) positron emission tomography (PET) in imaging patients with liver cancer before undergoing surgery or transplant.
- Conditions
- Adult Hepatocellular Carcinoma, Resectable Hepatocellular Carcinoma, Cholangiocarcinoma, Benign Liver Tumor
- Trial name
- NCT02379377
- Testing
- Fluorine F 18 L-glutamate Derivative 18F-FSPG, Carbon C 11 Acetate, Positron Emission Tomography
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- M.D. Anderson Cancer Center
Intraoperative Bleeding
The Efficacy of the Administration of Fibrinogen in Liver Transplantation
Objective: To evaluate the efficacy of preoperative administration of fibrinogen in liver transplantation by maintaining a preoperative plasma level equal to 2.9 g / L compared with placebo, reflecting a reduction in the number…
- Trial name
- FibstudLT (NCT01539057)
- Testing
- Fibrinogen, Saline
- Where
- 4 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Liver Transplant Infection, Surgical Site Infection
Pharmacological Study of Cefazolin Antibioprophylaxis in Liver Transplantation
This study describes Cefazolin pharmacokinetics variation to target levels during liver transplantation.
- Conditions
- Liver Transplant Infection, Surgical Site Infection, Antibiotic Prophylaxis, Cephazolin Adverse Reaction
- Trial name
- ProCeTH (NCT04280237)
- Testing
- Blood samples
- Where
- France
- Sponsor
- University Hospital, Tours
Liver Transplantation, Thrombin
Thrombin Generation in Liver Transplant Surgery
This is a prospective observational study of 100 patients undergoing liver transplantation at a single centre. Thrombin generation and kinetics will be assessed using a novel point-of-care device, and compared to conventional…
- Conditions
- Liver Transplantation, Thrombin, Hemostasis, Surgical, Blood Coagulation Disorder Due to Liver Disease
- Trial name
- NCT04762550
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Postperfusion Syndrome
Reperfusion Syndrome and Vasoplegic Syndrome in Liver Transplant Surgery
The incidence of postreperfusion syndrome (PRS) and vasoplegic syndrome (VS) is unknown, and occasionally can be confused since these syndromes share some hemodynamic characteristics.
- Trial name
- NCT05658120
- Testing
- noradrenaline/adrenaline
- Where
- Spain
- Volunteers
- 246 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Liver Resection, Liver Tumours
Evaluation Of Liver Resection Using Harmonic Scalpel Versus Cavitron Ultrasonic Surgical Aspirator (CUSA).
Evaluation Of Liver Resection Using Harmonic Scalpel Versus Cavitron Ultrasonic Surgical Aspirator (CUSA) Introduction The mode of parenchymal transection in hepatic resection has been a topic of great debate for decades.
- Conditions
- Liver Resection, Liver Tumours, Liver Transplant Disorder, Trauma Abdomen
- Trial name
- NCT07142876
- Testing
- Liver resection Cavitron Ultrasonic Surgical Aspirator (CUSA), Liver resection with the harmonic scalpel
- Volunteers
- 50 people
- Sponsor
- Sohag University
ABO Incompatibility, Liver Transplant Surgery
Study on the Clinical Outcomes of ABO-Incompatible Living Donor Liver Transplantation
Evaluate the postoperative survival rate and incidence of rejection in patients undergoing ABO-incompatible living donor liver transplantation; analyze the occurrence of secondary endpoint events such as postoperative vascular…
- Conditions
- ABO Incompatibility, Liver Transplant Surgery, Living Donor Liver Transplantation
- Trial name
- NCT07273448
- Volunteers
- 100 people
- Sponsor
- Zhi-Jun Zhu
Biliary Stricture
WallFlex Biliary Fully Covered (FC) Benign Stricture Study
The purpose of this study is to evaluate the safety and performance of the WallFlex® Biliary RX Fully Covered Stent as a treatment of biliary obstruction resulting from benign bile duct strictures.
- Trial name
- NCT01014390
- Testing
- WallFlex Biliary RX Fully Covered Stent System
- Where
- 13 sites in Australia, Austria and 9 more
- Volunteers
- 187 people
- Sponsor
- Boston Scientific Corporation
Liver Transplant Surgery
Sugammadex and Quantitative Monitoring in "Fast-Track Anesthesia" During Liver Transplantation
The purpose of this research is to estimate the frequency of postoperative lasting muscle weakness in patients receiving Sugammadex after undergoing liver transplant surgery by using electromyographic device (EMG), such as…
- Trial name
- NCT05216991
- Testing
- TetraGraph on dominant hand, TetraGraph on non-dominant hand
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Mayo Clinic
Liver Diseases, Liver Cirrhosis
Intraoperative Phlebotomies and Bleeding in Liver Transplantation
Liver transplantation are surgeries associated with important bleeding and often require perioperative red blood cell (RBC) transfusions.
- Conditions
- Liver Diseases, Liver Cirrhosis, Surgery, Surgery--Complications
- Trial name
- TOF_PHLEBO (NCT04826666)
- Where
- Canada
- Volunteers
- 679 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Mindfullnes-Based Cognitive Therapy and Adherence to Immunosuppressive Therapy
Mindfullnes-Based Cognitive Therapy Effect
Objective: In this study, the effect of mindfulness-based cognitive therapy on compliance with immunosuppressive therapy in liver transplant patients was evaluated.
- Trial name
- [Mindfullnes] (NCT05995938)
- Testing
- Mindfullnes-Based Cognitive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- SEMRA BÜLBÜLOĞLU
Other Surgical Procedures
Safety and Efficacy of Stem Cell Transplantation for Treatment of Liver Cirrhosis
Mainstream of current treatment of liver cirrhosis is liver transplantation, but there are high cost, risk and immune rejection and other issues.
- Trial name
- NCT01491165
- Testing
- stem cell transplantation through interventional procedures
- Where
- China
- Volunteers
- 75 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Cirrhosis, Liver, Liver Transplant Surgery
Online Prehabilitation for Patients Awaiting Liver Transplantation
Physical frailty is common in patients awaiting liver transplantation and has been associated with poor health outcomes. There is promising data from small studies showing that behavioural, nutrition, exercise therapy…
- Conditions
- Cirrhosis, Liver, Liver Transplant Surgery, Liver Disease
- Trial name
- OPAL (NCT05899231)
- Testing
- Prehabilitation Programming
- Where
- 6 sites in Canada
- Volunteers
- 177 people
- Sponsor
- University of Alberta