Clinical trials: Liver Transplantation (LT)
Liver Transplantation, HIV Infections
Effectiveness of Raltegravir-Based Antiretroviral Therapy in HIV-HCV Coinfected Liver Transplant Recipients
This is a retrospective observational multicenter cohort study based on 271 consecutive HIV-HCV coinfected patients who underwent liver transplantation (LT) between 2002 and 2012 in 23 centers from Spain and who were…
- Conditions
- Liver Transplantation, HIV Infections, Antiretroviral Therapy
- Trial name
- RAL-LT-HIV (NCT02995824)
- Testing
- Raltegravir-based antiretroviral therapy
- Volunteers
- 271 people
- Sponsor
- Hospital Clinic of Barcelona
Liver Transplantation (LT)
Intraoperative Glycemic Variability and Infectious Complications After Liver Transplantation
This study aims to evaluate whether intraoperative glycemic variability (GV) is independently associated with the risk of infectious complications within 30 days after elective liver transplantation.
- Trial name
- SUGAR-LT (NCT07786857)
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Invasive Fungal Infections, Lung Transplantation
Isavuconazole Therapeutic Drug Monitoring in Transplant Recipients
Isavuconazole is an antifungal medicine used to prevent or treat serious fungal infections in people who have received a solid organ transplant (mainly lung, and also kidney or liver) or a hematopoietic stem cell (bone marrow)…
- Conditions
- Invasive Fungal Infections, Lung Transplantation, Hematopoietic Stem Cell Transplantation (HSCT), Kidney Transplantation
- Trial name
- TRIM-1 (NCT07716878)
- Testing
- Isavuconazole
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhibin Xu
Autoimmune Liver Disease, Liver Transplant Disorder
A Study of SIPLIZUMAB in AILD and LT Patients
There is a significant unmet need for safe and effective therapeutic approaches to prevent immune-mediated graft injury and its complications in liver transplant (LT) recipients with autoimmune liver disease (AILD) including…
- Conditions
- Autoimmune Liver Disease, Liver Transplant Disorder, Autoimmune Hepatitis, Primary Sclerosing Cholangitis
- Trial name
- SET-SAIL (NCT06455280)
- Testing
- Siplizumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Elizabeth C. Verna
Liver Transplant, Hepatocellular Carcinoma
Efficacy and Safety of Liver Transplantation for Hepatocellular Carcinoma With Bile Duct Tumor Thrombus: a Single-arm, Multicenter, Prospective Study (HCC-BDTT in LT)
The prognosis for patients diagnosed with hepatocellular carcinoma with bile duct tumor thrombus (BDTT-HCC) remains notably grim, as there are presently no universally accepted treatment guidelines in place to address this…
- Conditions
- Liver Transplant, Hepatocellular Carcinoma, Bile Duct Tumor Thrombus
- Trial name
- NCT06928415
- Volunteers
- 130 people
- Sponsor
- Zhejiang University
Evidence of Liver Transplantation
The Study to Evaluate Efficacy and Safety of MY-REPT Capsule in Primary, Liver Transplantation Recipients (MYLT1)
Efficacy and safety of MY-REPT capsule in primary, liver transplantation recipients
- Trial name
- NCT01766518
- Testing
- Mycophenolate mofetil
- Where
- 3 sites in South Korea
- Volunteers
- 120 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Cholangiocarcinoma Non-resectable, Cholangiocarcinoma Recurrent
En Bloc Resection of the Liver and Pancreas With a "Non-touch" Technique Followed by Liver Transplantation to Improve the Overall Survival in Patients With Non-resectable Hilar Cholangiocarcinoma Beyond the Mayo Clinic Transplant Criteria
Surgery for hilar cholangiocarcinoma (phCCA) remains a significant challenge. The minority of patients who are eligible for resection are exposed to high procedure-related morbidity and mortality, and despite apparent R0…
- Conditions
- Cholangiocarcinoma Non-resectable, Cholangiocarcinoma Recurrent, Liver Transplantation
- Trial name
- SURE-LT (NCT06850753)
- Testing
- Liver transplantation after en bloc resection of the liver and pancreas
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Patients Cannulated With Both PICC and CICC., The Rapidly Fluctuating Hemodynamics During LT.
Comparison of Central Venous Pressures (CVPs) Measured From Peripherally Inserted Central Catheters (PICC) and CICC in Liver Transplantation Recipients
Background: Central venous pressure (CVP) monitoring from the peripherally inserted central venous catheter (PICC) has not often been used because of the higher inherent resistance of the PICC due to its longer length and…
- Trial name
- PICC (NCT00988871)
- Testing
- PICC, CICC
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- National Cancer Center, Korea
Liver Metastasis Colon Cancer
LT for Unresectable Colorectal Liver Metastasis
Unlike hepatocellular carcinoma, liver transplantation in patients with liver metastasis from colorectal cancer is limited in only few centers.
- Trial name
- NCT04874259
- Testing
- Living donor liver transplantation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Asses Immunosuppression Modulation on Renal Recovery Post LT
Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
This is a study to help understand how well new combinations of immunosuppressive medications (medications that weaken your immune system to prevent your body from rejecting the transplanted liver) work compared to standard…
- Trial name
- NCT04104438
- Testing
- Basiliximab 20 MG
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Fady M Kaldas, M.D., F.A.C.S.
Liver Cancer, Tumor Recurrence
HOPE to Reduce Tumour Recurrence After LT In Patients With HCC
Hypothermic oxygenated ex-situ machine perfusion (HOPE) is a dynamic preservation method that has been developed to reduce the incidence and severity of ischaemia-reperfusion injury and to improve outcomes after liver…
- Conditions
- Liver Cancer, Tumor Recurrence, Hepatocellular Carcinoma, Liver Transplantation
- Trial name
- POTERE (NCT05876052)
- Testing
- Hypothermic oxygenated Perfusion - HOPE
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- University of Bologna
Liver Diseases
Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery
We compared the time consumed for goal-directed management of hypofibrinogemia using two strategies during liver transplant (LT) surgery: a conventional cryoprecipitate-based strategy versus a lyophilized fibrinogen…
- Trial name
- NCT06144112
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Liver Transplantation (LT)
Mental Health Outcomes and Psychological Evaluation After Liver Transplantation
Receiving a liver transplant is a major life event that can be physically and emotionally challenging. During the first five years after transplantation, more than one in two liver transplant recipients experience a mental health…
- Trial name
- mHOPE (NCT07734142)
- Testing
- questionnaires, Individual semi-structured interview
- Volunteers
- 250 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
End-stage Liver Disease, Liver Cirrhosis
Nutrition and Exercise Prehabilitation in Patients Awaiting Liver Transplantation
This study aims to evaluate the effects of a diet with even protein distribution plus exercise (Group A) versus a diet with skewed protein distribution plus exercise (Group B) versus standard dietary and physical activity advice…
- Conditions
- End-stage Liver Disease, Liver Cirrhosis, Liver Transplantation, Malnutrition
- Trial name
- POWER-LT (NCT07561138)
- Testing
- Diet with even protein distribution plus exercise program, Diet with skewed protein distribution plus exercise program, Standard dietary and physical activity advice
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- Kalliopi Anna Poulia
Liver Transplantation
Data Collection Study From Donors and Recipients to Optimize Donor-recipient Matching in Liver Transplantation
A major limitation of liver transplantation is organ shortage. To avoid exposing patients to death on the waiting list, organs are used that would have been discarded few years ago.
- Trial name
- OPTIMATCH-LT (NCT03371264)
- Volunteers
- 9,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplantation (LT), End-stage Liver Disease (ESLD)
Restrictive Fluid Management In Liver Transplantation (REFIL)
The goal of the REFIL-2 study is to evaluate the effectiveness of a low splanchnic blood volume restrictive fluid management strategy (a strategy that involves limiting fluid administration and prioritizing the use of medications…
- Trial name
- REFIL-2 (NCT07695363)
- Testing
- Low splanchnic blood volume restrictive fluid management strategy, Phlebotomy, Optimized cardiac output liberal fluid management strategy
- Where
- 4 sites in Canada
- Volunteers
- 866 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)