Clinical trials: Liver Transplants
Identify More Accurate Predictive Models of Transplant Risk to Monitor and Evaluate New and Existing Patient Factors
Hepatic Transplantation Registry
The objective is to provide a mechanism to store information regarding the demographic characteristics; pre-, intra-, and post-transplant laboratories; treatment strategies; complications; and outcomes in patients undergoing…
- Trial name
- NCT05944042
- Testing
- Observational Transplant Analysis
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Methodist Health System
Zhejiang University
Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
The primary objective of this study was to assess the safety and feasibility of split liver transplantation(SLT) for adult hepatocellular carcinoma (HCC) patients, while comparing the prognostic disparities between adult SLT and…
- Trial name
- NCT06359496
- Testing
- No intervention factor
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Hepatocellular Carcinoma of the Liver, Subjects Eligible for Liver Transplantation
Bridge to Orthotopic Liver Transplantation (OLT) - Surefire Precision vs Endhole Embolization With DEBTACE
The purpose of this study will be to prospectively evaluate the outcomes of patients with hepatocellular carcinoma (HCC) who undergo DEB-TACE (drug-eluting bead trans-arterial chemoembolization) with the Surefire Precision…
- Trial name
- SPEED (NCT03170869)
- Testing
- Surefire Precision Infusion System
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Liver Transplantation
S100β and Neuron Specific Enolase Levels in Liver Transplantation
Several neurological problems which include both central nervous system and peripheral nervous system can occur as a result of acute liver failure or severe chronic liver failure.
- Trial name
- NCT03453047
- Testing
- S100β and Neuron specific enolase (NSE)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bora Dinc
Organ Preservation, Liver Transplantation
Long-term Outcomes After Hypothermic Oxygenated Machine Perfusion of Donor Livers Using Real-world Data
End-ischemic hypothermic oxygenated machine perfusion (HOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Conditions
- Organ Preservation, Liver Transplantation, Hypothermic Machine Perfusion
- Trial name
- HOPE-REAL (NCT05520320)
- Testing
- Hypothermic oxygenated machine perfusion (any device)
- Where
- 2 sites in Netherlands, Switzerland
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Healthy Donors for Liver Transplantation
Comparison of Postoperative Outcome of Hepatectomy for Living Donors According to Three Different Incision
Living donor liver transplantation (LDLT) is an important option for patients with end-stage liver disease requiring liver transplantation. When performing LDLT, the safety and well being of donors is of the utmost importance.
- Trial name
- NCT02413983
- Testing
- hepatectomy conventional incision, hepatectomy midline incision, hepatectomy transverse incision
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
End Stage Liver DIsease, Liver Transplantation
Effect of Transfusion of Plasma on Endothelial During Liver Transplantation
To study the effects of plasma transfusionon during liver transplantation on endothelial condition and short-term outcome in patients with end-stage liver disease.
- Trial name
- NCT04107883
- Testing
- fresh frozen plasma, blood sample
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Liver Transplant; Complications, HLA Antigens
The Relationship Between HLA Tissue Compatibility and Biliary Complications in Patients With Liver Transplantation
Liver transplantation has become the accepted treatment option for advanced liver failure in recent years. In addition to the increase in the number of centers performing transplant and the decrease in complication rates…
- Trial name
- NCT04885582
- Testing
- HLA antigen results
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Inonu University
Education
Video-supported Training in Line With the Health Belief Model
Summary The only treatment method for those with incurable, irreversible, progressive, acute or chronic liver disease is liver transplantation.
- Trial name
- NCT06138379
- Testing
- Experimental: 1st Experimental Group, Experimental: 2nd Experimental Group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Inonu University
Right Hepatectomy
Hepatic Hemodynamic Changes and Simulation in Living-Related Liver Transplantation
This 1-year project is intended to study the hemodynamic changes of poratal and hepatic artery during living related liver transplantation.
- Trial name
- NCT00234624
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anxiety Postoperative
Anxiety Levels in Living Liver Donors
Anxiety is a state of worry and apprehension caused by internal and external threats. High preoperative anxiety levels have been associated with increased anesthetic requirements, higher morbidity, and mortality rates.
- Trial name
- NCT07576920
- Testing
- Anxiety scores
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplant; Complications, Inflammatory Response
Effect of Transversus Abdominis Plane Block on Anti-inflammatory Response
The liver transplantation is the only treatment for end-stage liver failure. Lack of sufficient organs from the cadaver to meet the organ needs has increased the interest in a live organ donor transplantation.
- Trial name
- NCT04232904
- Testing
- Transversus abdominous plane block (TAP Block)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Diseases, Transplant-Related Disorder
Liver Transplantation: Skeletal Effects
Fifty patients awaiting liver transplantation and 50 age and gender matched control subjects with normal liver function will be included in the study.
- Conditions
- Liver Diseases, Transplant-Related Disorder, Osteoporosis
- Trial name
- NCT03399227
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Minimal Hepatic Encephalopathy
Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation
This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls…
- Trial name
- NCT02767622
- Testing
- Liver transplantation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Fecal Microbiota Transplantation, Orthotopic Liver Transplantation
Fecal Microbiota Transplantation for the Prevention of Infectious Complications After Liver Transplantation
The increasing emergence and spread of MDRB represents a major public health problem, with higher mortality in patients experiencing infections.
- Conditions
- Fecal Microbiota Transplantation, Orthotopic Liver Transplantation, Multi-drug Resistant Bacteria
- Trial name
- NCT06782880
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Italy
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Transplantation
Investigation of the Effects of Motor Cognitive Dual Task Exercises on Cognitive Function, Balance and Functional Capacity in Patients Who Have Undergone Liver Transplantation.
Liver transplantation is a life-saving treatment of choice for patients with acute or chronic liver failure. Liver transplantation is performed with a graft taken from a living donor or cadaver in patients with end-stage liver…
- Trial name
- NCT05909371
- Testing
- exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Liver Diseases
Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery
We compared the time consumed for goal-directed management of hypofibrinogemia using two strategies during liver transplant (LT) surgery: a conventional cryoprecipitate-based strategy versus a lyophilized fibrinogen…
- Trial name
- NCT06144112
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Neuroendocrine Tumors
Liver Transplantation Versus Conventional Medical Therapy for Low-Grade GEP-NET With Liver Metastases
Liver Transplantation Versus Conventional Medical Therapy for Low-Grade GEP-NET With Liver Metastases
- Trial name
- TRANET-GEP (NCT07913113)
- Testing
- Liver Transplantation
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiyi Chen
End-stage Liver Disease (ESLD), Liver Transplantation
View of Cerebral Perfusion in Liver Transplantation
Investigator's aim in this study is to compare the more accessible and low-cost Carotid Doppler USG measurements, which are relatively more difficult to access, costly, and have technical disadvantages, and to demonstrate their…
- Conditions
- End-stage Liver Disease (ESLD), Liver Transplantation, Cerebral Perfusion, Intraoperative Monitoring
- Trial name
- NIRS/Doppler (NCT07442214)
- Testing
- Carotid Doppler Ultrasonography and Near-Infrared Spectroscopy (NIRS)
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Inonu University
Liver Transplant Rejection, Liver Transplant; Complications
Safety of DNP007 in Healthy Subjects
This clinical trial evaluated the safety, tolerability, pharmacokinetic properties, and immunogenicity of DNP007 when administered as a single dose.
- Conditions
- Liver Transplant Rejection, Liver Transplant; Complications, Steatohepatitis, Nonalcoholic
- Trial name
- NCT06400771
- Testing
- DNP007
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital