Clinical trials: Liver Transplants
End Stage Liver Disease
Functional Assessment in Liver Transplantation
This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic…
- Trial name
- FrAILT (NCT03228290)
- Where
- 12 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of California, San Francisco
Immunosuppression
Conversion of CellCept to Myfortic: A Prospective Study in Liver Transplant Recipients
The objective of this study is to determine the tolerability and safety of Myfortic in liver transplant patients. Patients receiving CellCept who have GI side effects will have CellCept discontinued and changed to Myfortic…
- Trial name
- NCT00336895
- Testing
- Myfortic
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pittsburgh
Non-Alcoholic Steato-Hepatitis, Liver Cirrhosis
Genetic Studies of Non-Alcoholic Fatty Liver Disease
Background: Non-alcoholic fatty liver disease is the most common form of liver disease in the United States. It includes many conditions.
- Conditions
- Non-Alcoholic Steato-Hepatitis, Liver Cirrhosis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT01629095
- Where
- 5 sites in United States
- Volunteers
- 17 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Liver Transplantation, Acute Kidney Injury
Influence of Human Albumin Supplementation on Kidney Dysfunction After Liver Transplantation
To verify whether albumin administration to achieve serum concentration above 30g/L (treated group) and its maintenance within plasmatic physiologic range (above 30 g/L) for five days diminishes rate of AKI at Day 7 after liver…
- Trial name
- HALT (NCT06535945)
- Testing
- Albumin administration
- Where
- 8 sites in France
- Volunteers
- 400 people
- Sponsor
- Rennes University Hospital
Evidence of Liver Transplantation
Uses of Immunosuppression Therapy in Patients With Liver Transplantation
Conventionally, the outcome of liver transplantation is usually reported in terms of graft and patient survival, medical and surgical complications, but lack of health-related quality of life (HRQOL) that might be associated with…
- Trial name
- NCT01834690
- Where
- Taiwan
- Volunteers
- 314 people
- Sponsor
- Chang Gung Memorial Hospital
Liver Transplantation, Surgical Wound Infection
Glycemic Control and Surgical Site Infection Incidence Among Liver Transplantation Recipients
Context: The hyperglycemia is an important independent risk factor for the Surgical Site Infection (SSI) development among liver transplantation recipients.
- Trial name
- NCT03474666
- Testing
- Strict Glycemic Control Group, Standard Glycemic Control Group
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- Ramon Oliveira
Recurrent Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8
Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant
This phase II trial evaluates lenvatinib for the treatment of hepatocellular carcinoma (HCC) that has come back (recurrent) after a liver transplant.
- Conditions
- Recurrent Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8
- Trial name
- NCT05103904
- Testing
- Laboratory Biomarker Analysis, Lenvatinib
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Liver Failure, Acute Kidney Disease
Intraoperative Dialysis in Liver Transplantation
Patient with liver failure waiting for liver transplantation are often hospitalized and commonly supported in an intensive care unit prior to surgery.
- Conditions
- Liver Failure, Acute Kidney Disease, Multi-organ Failure
- Trial name
- INCEPTION (NCT01575015)
- Testing
- Continuous renal replacement therapy (CRRT), Standard intraoperative support
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Liver Transplant
Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function.
- Trial name
- ELIMINATE (NCT06280950)
- Testing
- Everolimus, Tacrolimus (continued reduction), Tacrolimus (maintain 50% reduction)
- Where
- 12 sites in United States
- Volunteers
- 340 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Living Donor Liver Transplantation
The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study
Rationale: Living donor liver transplantation (LDLT) offers a promising solution to the organ shortage. During living liver donation, a substantial portion of the donor's liver is resected.
- Trial name
- LRLDLT (NCT07329296)
- Testing
- Living liver donation
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Erasmus Medical Center
Liver Transplant; Complications
Placement of Biliary Drainage Stent to Prevent Biliary Intestinal Anastomosis After Liver Transplantation in Children
Liver transplantation is an effective method for treating end-stage liver disease and metabolic diseases in children. With the advancement of surgical techniques and the improvement of perioperative management, the survival rates…
- Trial name
- NCT06048445
- Testing
- intraoperative plancement of Biliary Drainage Stent
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Zhejiang University
De Novo Autoimmune Hepatitis
De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation
The purpose of this study is to provide insights into the cause, development and effects of de novo autoimmune hepatitis so that prevention and treatment strategies can be developed in order to reduce post-liver transplant…
- Trial name
- NCT02056054
- Testing
- Pediatric transplant subject with d-AIH, Pediatric transplant subject with acute rejection, Pediatric transplant subject with chronic rejection
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Yale University
Liver Transplantation, Physical Fitness
A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise Intensity
Research demonstrated that transplant recipients benefit from physical activity, but there is a gap in knowledge regarding the required intensity.
- Trial name
- PHOENIX-L (NCT06302205)
- Testing
- Physical activity
- Where
- Belgium
- Volunteers
- 147 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hepatitis C
Orthotopic Liver Transplant (OLT) Recipients With Hepatitis C Virus (HCV) Under Preemptive Treatment
After a liver transplant, the hepatitis C virus (which destroyed one's own liver) eventually comes back. In many patients, this will eventually cause the loss of the new liver and can also confuse the doctors taking care of them…
- Trial name
- NCT00167557
- Testing
- Pegylated Interferon, Ribavirin, Liver Biopsy
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Liver Transplantation, Infection
Efficacy and Safety of Basiliximab, Cyclosporine/Cyclosporine Microemulsion, and Steroids in Pediatric de Novo Liver Transplant Recipients Avoiding Intraoperative Steroids
Systemic infection is still a major concern in young children with liver transplantation. The approach of this study is to reduce the risk of systemic infections by avoiding intraoperative steroids (another class of…
- Trial name
- NCT00149890
- Testing
- Basiliximab, Cyclosporine/cyclosporine microemulsion, Steroid
- Where
- Germany
- Volunteers
- 77 people
- Sponsor
- Novartis
Hepatocellular Carcinoma
Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer
This trial studies how well stereotactic body radiation therapy works in treating patients with liver cancer. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with…
- Trial name
- NCT03812289
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- OHSU Knight Cancer Institute
Intrahepatic Cholangiocarcinoma, Locally Advanced Intrahepatic Cholangiocarcinoma
Liver Transplantation for Locally Advanced Intrahepatic Cholangiocarcinoma After SIRT and Chemotherapy
The study hypothesis is that liver transplantation after selective internal radiation therapy (SIRT) and chemotherapy would improve 3-year overall survival in patients with locally advanced (unresectable but non-metastatic)…
- Trial name
- RIS-TH (NCT06910722)
- Testing
- Liver transplant
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fungemia, Mycoses
Voriconazole as Prophylaxis for Liver Transplant Recipients
The study aims to determine if voriconazole prevents invasive fungal infections in liver transplant recipients. Endpoints would be: occurrence of invasive fungal infection and fungal colonization.
- Trial name
- NCT00177788
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Pittsburgh
Cancer of Liver
Incorporation of Protein Induced by Vitamin K Absence or Antagonist-II Into Transplant Criteria Expands Beneficiaries of Liver Transplantation for Hepatocellular Carcinoma
This is a multi-center study in China to investigate the role of PIVKA-II in HCC recipient selection and prognostic stratification by analyzing the data of 522 recipients with HCC registered in the China Liver Transplant Registry.
- Trial name
- NCT05907772
- Testing
- No intervention
- Where
- China
- Volunteers
- 522 people
- Sponsor
- Zhejiang University
Liver Transplants
Estimation of Steatosis on Liver Transplants by Intraoperative Spectrometry
The goal is to have a small spectrometer (pocket size) , reliable and rapid tool that can be used during liver harvesting, which enables macrosteatosis to be evaluated reproducibly and selectively, at any time.
- Trial name
- iGRAISSE (NCT05106322)
- Testing
- intraoperative spectrometer scan
- Where
- 3 sites in France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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