Clinical trials: Liver Transplants
Liver Transplantation
Immunosuppressive Therapy Optimization: Development of a Population Pharmacokinetic-pharmacodynamic (PK-PD) Model in Liver Transplantation
Prospective, non-randomized, open Pharmacokinetic-Pharmacogenetic-Pharmacodynamic monocentric study. Donor and recipient CYP3A5 genotype and recipient ABCB1 will not be communicate to clinicians or patients during the study.
- Trial name
- OPTILTH (NCT02877628)
- Testing
- Pharmacokinetic-pharmacodynamic model in liver transplantation
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Rennes University Hospital
Liver Transplant
Liver Transplantation With Tregs at MGH
This is a single-center, prospective, open-label, non-randomized clinical trial exploring cellular therapy to facilitate immunosuppression withdrawal in liver transplant recipients.
- Trial name
- LITTMUS-MGH (NCT03577431)
- Testing
- arTreg-CSB, leukapheresis, cyclophosphamide
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplantation
Benefit of Immunoprophylaxis on Fibrosis to Reduce Viral Load After Liver Transplantation
An open-label randomized multicenter clinical study comparing three regimes of immunosuppression : (A) tacrolimus and steroids, (B) antithymocyte induction therapy and full dose of tacrolimus, (C) antithymocyte induction therapy…
- Trial name
- BEFIRTH (NCT00538265)
- Testing
- tacrolimus, tacrolimus, ATG, ATG+mycophénolate mofétil+tacrolimus
- Where
- 8 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Liver Transplantation (LT), Immuno-suppression
Immune Biomarkers for Predicting Complications After Liver Transplantation
This multicenter prospective observational study will evaluate immune biomarkers in adults undergoing liver transplantation. The study aims to describe how immune markers change before and after transplantation and to assess…
- Conditions
- Liver Transplantation (LT), Immuno-suppression, Biomarkers / Blood, Rejection
- Trial name
- NCT07875595
- Testing
- Immune Biomarker Assessment
- Where
- 3 sites in Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Frailty, Sarcopenia
The Effect of the COVID-19 Pandemic on Frailty in Liver Transplant Candidates
Frailty is associated with higher rates of morbidity, mortality, and failure to rescue after major surgical procedures. Sarcopenia is degenerative loss of skeletal muscle mass and strength.
- Conditions
- Frailty, Sarcopenia, COVID-19
- Trial name
- NCT05935800
- Testing
- COVID Patients who Underwent pre-transplant frailty assessment (PFA) at MDMC
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Methodist Health System
Liver Transplantation
Enteric Coated Myfortic for Liver Transplant Recipients
The purpose of this study is to replace the mycophenolate mofetil (Cellcept) which is our usual therapy after liver transplantation with sodium mycophenolic acid (Myfortic®) and to find out the effect this change may have on the…
- Trial name
- NCT00167492
- Testing
- Myfortic
- Where
- United States
- Sponsor
- The University of Texas Health Science Center, Houston
Liver Transplant; Complications, Bile Duct; Stricture, Postoperative
The Effect of the Type of Conduit-duct Anastomosis Technique on the Postoperative Course in Patients Undergoing Liver Transplantation
The main objective of the trial is to compare the effect of two end-to-end duct-to-duct anastomosis surgical techniques using the continuous suture method versus interrupted method (control group) on reducing the risk of bile…
- Conditions
- Liver Transplant; Complications, Bile Duct; Stricture, Postoperative, Bile Leak, Quality of Life
- Trial name
- NCT06533592
- Testing
- Continous suture technique, Interrupted suture technique
- Where
- Poland
- Volunteers
- 284 people
- Sponsor
- Medical University of Warsaw
Pediatric Liver Transplantation
Thromboelastometry as a Predictor of Thrombotic Complications During Pediatric Recipient Liver Transplantation
The study aims to correlate the perioperative results of a device called thromboelastogram, which is used to detect coagulation abnormalities, with thrombotic complications during pediatric recipient liver transplantation.
- Trial name
- NCT03494595
- Testing
- Pediatric Liver transplantation
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Liver Transplant; Complications, Diabetes Mellitus
Semaglutide vs Sitagliptin
The effect of once daily dosing of oral Semaglutide versus once daily dosing Sitagliptin on glycemic control, body weight, and safety and tolerability will be compared in Liver Transplant Recipients with poorly-controlled…
- Conditions
- Liver Transplant; Complications, Diabetes Mellitus, NASH - Nonalcoholic Steatohepatitis, NAFLD
- Trial name
- NCT05195944
- Testing
- Semaglutide Treatment, Sitagliptin 100mg
- Where
- Canada
- Volunteers
- 58 people
- Sponsor
- University Health Network, Toronto
Hepatic Transplantation, Rejection; Transplant, Liver
Tissue Analysis of Liver Grafts as a Predictor of Transplant Outcome.
Despite the good clinical results in terms of outcome with the application of HOPE prior to liver transplantation, very little is still known about the phenotypic and molecular changes that occur during perfusion/preservation…
- Trial name
- NCT06717542
- Testing
- histochemical and immunohistochemical analysis, RT-PCR
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Liver Transplantation
Endotracheal Cardiac Output Monitor (ECOM) for Patients Undergoing Liver Transplantation
The purpose of this study is to determine whether the endotracheal cardiac output monitor (ECOM) is accurate and predictive in liver failure patients with hyperdynamic circulatory changes.
- Trial name
- NCT01299441
- Testing
- ECOM ETT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Hepatocellular Carcinoma (HCC), Living Donor Liver Transplantation
Efficacy of Loco-regional Treatment for Hepatocellular Carcinoma Prior to Living Donor Liver Transplantation in Egypt
This study aimed to analyze the outcomes of loco-regional treatment prior Living Donor Liver Transplantation in patients with HCC.
- Trial name
- NCT02990351
- Testing
- loco regional therapies for HCC
- Volunteers
- 29 people
- Sponsor
- Ain Shams University
Chronic Liver Disease
Comparing Portal Vein Assessment by Intraoperative Doppler and Transesophageal Echocardiography
Liver transplantation is usually associated with hemodynamic instability. TEE allows for a real time monitoring of cardiac structures and has become a standard of care for liver transplant patients.
- Trial name
- NCT06909175
- Testing
- Transesophageal echocardiography
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Intraoperative Bleeding
The Efficacy of the Administration of Fibrinogen in Liver Transplantation
Objective: To evaluate the efficacy of preoperative administration of fibrinogen in liver transplantation by maintaining a preoperative plasma level equal to 2.9 g / L compared with placebo, reflecting a reduction in the number…
- Trial name
- FibstudLT (NCT01539057)
- Testing
- Fibrinogen, Saline
- Where
- 4 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Liver Transplant; Complications
Darbepoetin in Patients Candidates for Liver Transplant. (EPO-LT Trial)
This is a national multicenter, randomized clinical trial to evaluate the the efficacy and safety of DP administration in patients on the liver transplant waiting list to reduce intraoperative red blood cell concentrate…
- Trial name
- EPO-LT (NCT07169643)
- Testing
- Darbepoetin (DP)
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Liver Failure
Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients
The purpose of this study is to demonstrate the pharmacokinetics (PK, measuring the amount of medication in blood samples) and safety of a new medicine, LCP-Tacro™ tablets, and Prograf® capsules, a drug commonly taken by…
- Trial name
- NCT00772148
- Testing
- LCP -Tacro, Prograf
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Veloxis Pharmaceuticals
Acute Kidney Injury, Renal Insufficiency, Chronic
Safety of Iodinated Contrast in Liver Transplant Candidates With Decreased Renal Function Undergoing Coronary CT Angiography
This study evaluates the safety of iodinated contrast medium administered to liver transplant candidates with decreased renal function undergoing coronary CT angiography.
- Conditions
- Acute Kidney Injury, Renal Insufficiency, Chronic, Contrast-induced Nephropathy, Liver Transplantation
- Trial name
- NCT03806725
- Testing
- Intravenous administration of iodinated contrast medium for coronary CT angiography
- Where
- United States
- Sponsor
- Stanford University
Liver and Biliary Tract Disorders in Duration of Pregnancy, Other End-stage Liver Diseases in Children
Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study
The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort.
- Trial name
- NCT06045949
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Huiwu Xing
Postoperative Ileus
Effect of Sham Feeding on Postoperative Ileus After Elective Liver Transplantation
Postoperative ileus is a common after abdominal surgery. Multifactorial etiology such as surgical trauma, bowel manipulation and perioperative opioids contributes to delayed return of normal gut function Chewing gum has recently…
- Trial name
- NCT01956643
- Testing
- gum chewing, Control
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Liver Transplantation
Reduction in the Risk of Rejection by Mycophenolate Mofetil Dose Adjustment in Liver Transplant Patients With Side Effects Caused by the Calcineurine Inhibitors
The aim of this project is to determine whether, in liver transplant patients with side effects due to ICN, the use of MMF in monotherapy can be optimised by dose adjustment based on the area under the curve (AUC) of mycophenolic…
- Trial name
- MONOCEPT (NCT00456235)
- Testing
- Mycophénolate Mofétil, Ciclosporine A, Tacrolimus
- Where
- 17 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Limoges
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