Clinical trials: Liver Transplants
End Stage Liver DIsease, Portal Hypertension
Somatostatin in Living Donor Liver Transplantation
Aim of the study is to investigate the safety and the efficacy of somatostatin as liver inflow modulator in patients with end-stage liver disease (ESLD) and clinically significant portal hypertension (CSPH) undergoing…
- Trial name
- NCT04107428
- Testing
- Somatostatin
- Volunteers
- 56 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Liver Transplantation, Renal Failure
A Feasibility Study of Octreotide Infusion During Liver Transplant.
The purpose of the study is to determine whether an octreotide infusion during liver transplantation improves renal outcomes, intraoperative blood pressure and reduces haemorrhage and transfusion requirement.
- Trial name
- Octreotide (NCT04941911)
- Testing
- Octreotide Acetate
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Liver Transplantation
Comparing Montiroing Cardiac Index by Transpulmonary Thermodilution and Transesophageal Echocardiography During Liver Transplantation
Liver transplantation poses challenges due to hemodynamic changes throughout different surgical phases. Monitoring devices are essential for therapeutic adjustments.
- Trial name
- NCT06899867
- Testing
- Measure of cardiac index with thermodilution and transesophageal echocardiography, Surgical anastomosis echography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Kidney Transplant; Complications, Liver Transplant; Complications
Project LIFT - Promoting Healthy Behavior Through a Wearable Fitness Device and Financial Incentives
Project LIFT is a randomized, controlled trial that tests the effectiveness of a remotely-monitored, home-based exercise program utilizing wearable fitness trackers to monitor steps taken per day, health engagement questions, and…
- Conditions
- Kidney Transplant; Complications, Liver Transplant; Complications, Obesity
- Trial name
- LIFT (NCT03221465)
- Testing
- Self-monitoring of physical activity with incentives, Usual care and self-monitoring of physical activity
- Where
- 2 sites in United States
- Volunteers
- 127 people
- Sponsor
- University of Pennsylvania
Hepatic Insufficiency, Liver Insufficiency
Liver Transplantation and Reticuloendothelial Clearance Capacity
Study summary: "Liver transplantation and the reticuloendothelial clearance capacity." The purpose of this study is to evaluate the effect of liver transplantation on the immune system.
- Trial name
- NCT00929032
- Testing
- Nanocoll®
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Edinburgh
Health Related Quality of Life
Health Related Quality of Life Assessment In Egyptian Recipients After Living Donor Liver Transplantation
Health Related Quality of Life Assessment In Egyptian Recipients After Living Donor Liver Transplantation
- Trial name
- NCT01784497
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Ain Shams University
Liver Transplant
Observational Study of Eating Behavior in Patients With Diabetes Mellitus and Obesity Undergoing Liver Transplantation
The study aims to evaluate the presence of eating disorders, which consists of having an altered relationship with food, in patients on the list or already undergoing liver transplantation.
- Trial name
- DCA-OLT-2020 (NCT06714786)
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Cancer, Kidney Cancer
Cancer Development In Organ Transplant Recipients
The investigators will determine the cancer risk in organ transplant recipients compared to the general population with the help of statistical analysis.
- Conditions
- Heart Cancer, Kidney Cancer, Lung Cancer, Pancreas Cancer
- Trial name
- NCT02333279
- Where
- Switzerland
- Volunteers
- 1,800 people
- Sponsor
- University of Zurich
Liver Transplant; Complications
Outcome Analysis of Aspirin in Liver Transplantation
In the experimental setting inhibition of platelet activation was able to reduce immune-mediated necroinflammatory liver disease and consecutively hepatocellular carcinoma development.
- Trial name
- NCT04327427
- Testing
- Aspirin
- Where
- Switzerland
- Volunteers
- 3,000 people
- Sponsor
- University of Zurich
Alcohol Use Disorder, Liver Transplant; Complications
Safety of Acamprosate in Treating Alcohol Use Disorder in the Post Liver Transplant Populations
Acamprosate for alcohol use disorder may benefit liver transplant (LT) recipients with alcohol-associated liver disease (ALD), yet data on feasibility and safety in LT recipients are lacking.
- Trial name
- NCT06471686
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Bleeding in Liver Transplantation
Plasma Transfusion in Liver Transplantation
The aim of the study is to compare the clinical efficacy of three types of plasma secured on the viral level either by quarantine or by chemical treatment in patients undergoing liver transplantation.
- Trial name
- NCT00235183
- Testing
- plasma
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Etablissement Français du Sang
Liver Transplantation
Transportation Assistance Program for Liver Transplant
We propose a rideshare-supported intervention that leverages a partnership with Lyft Health, a HIPAA-secured logistics solution that enables us to provide reliable and efficient transportation for patients.
- Trial name
- TAP-LT (NCT05080595)
- Testing
- Transportation assistance (Lyft rides)
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- University of Southern California
Liver Metastases, Colorectal Cancer Metastatic
Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation
The COLT trial is an investigator-driven, multicenter, non-randomized, open-label, controlled, prospective, parallel trial, aimed at assessing the efficacy (in terms of overall survival: OS) of liver transplantation (LT) in…
- Conditions
- Liver Metastases, Colorectal Cancer Metastatic, Liver Neoplasm, Neoplasms
- Trial name
- COLT (NCT03803436)
- Testing
- Liver transplant, Chemotherapy
- Where
- 12 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Terminal Liver Disease, Ischemia Reperfusion Injury
TOP-Study (Tacrolimus Organ Perfusion): Treatment of Ischemia Reperfusion Injury in Marginal Organs With an ex Vivo Tacrolimus Perfusion
Utilisation of extended criteria donors due to critical organ shortage contributes to increased ischemia reperfusion injury as well as mortality following liver transplantation.
- Conditions
- Terminal Liver Disease, Ischemia Reperfusion Injury, Graft Dysfunction, Graft Failure
- Trial name
- TOP (NCT01564095)
- Testing
- Tacrolimus
- Where
- 7 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Liver Transplantation (LT)
Intraoperative Glycemic Variability and Infectious Complications After Liver Transplantation
This study aims to evaluate whether intraoperative glycemic variability (GV) is independently associated with the risk of infectious complications within 30 days after elective liver transplantation.
- Trial name
- SUGAR-LT (NCT07786857)
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Medical University of Warsaw
Hepatitis C, Cirrhosis
Intravenous Interferon During Liver Transplant
The main goal of this study is to prevent liver allograft infection with Hepatitis C virus in hepatitis C positive patients undergoing liver transplantation.
- Trial name
- NCT01192698
- Testing
- IV interferon
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences
Liver Failure
The Relationship of Initial Liver Profile and Outcome After Transplantation
Donation after cardiac death (DCD) livers are increasingly utilised in liver transplantation but concerns exist regarding negative results.
- Trial name
- NCT02307890
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Cholangiocarcinoma
Registry Study of Neoadjuvant Chemoradiation & Transplant for Cholangiocarcinoma Patients
This is an observational study intended to validate results of a previous study done at the Mayo Clinic. Patients are treated with combination chemotherapy and radiation and maintained on oral Xeloda until they can receive liver…
- Trial name
- NCT00301379
- Testing
- Observation data collection study.
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Liver Transplantation, Infection
Italian National Study on the Critically Ill Liver Transplant Patient With an Infection
Despite major advances, infections remain one of the major causes of morbidity and mortality in patients undergoing orthotopic liver transplantation (OLT).
- Conditions
- Liver Transplantation, Infection, Sepsis, Intensive Care Unit
- Trial name
- INFE-OLT (NCT03363646)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Transplant-Related Disorder, Hepatitis B Virus Infection
Optimal Timing of Hepatitis B Vaccination After Transplants
The investigators aim to perform a randomized clinical trial to determine the optimal timing of hepatitis B vaccination after hematopoietic cell transplantation (HCT) through evaluating the immunity effect of two different…
- Conditions
- Transplant-Related Disorder, Hepatitis B Virus Infection, Vaccine Reaction
- Trial name
- NCT06888479
- Testing
- hepatitis B vaccine
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
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