Clinical trials: Liver Transplants
Liver Failure
A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantation
This is a 24-month, Phase II, multi-center, two-arm, randomized controlled study of adult patients receiving a single organ liver transplant from a deceased donor; the purpose being to determine the efficacy of Thymoglobulin®…
- Trial name
- NCT02544113
- Testing
- Thymoglobulin
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- The Cleveland Clinic
Cholangiocarcinoma
Registry Study of Neoadjuvant Chemoradiation & Transplant for Cholangiocarcinoma Patients
This is an observational study intended to validate results of a previous study done at the Mayo Clinic. Patients are treated with combination chemotherapy and radiation and maintained on oral Xeloda until they can receive liver…
- Trial name
- NCT00301379
- Testing
- Observation data collection study.
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Ileus
Interventions to Decrease the Impact of Post-OPerative Ileus After Liver Transplant or Resection Surgery
This is a randomized controlled trial to assess ways to address post-operative ileus (POI) in adult patients on the liver transplant service undergoing either liver transplant or resection surgery.
- Trial name
- NCT01156129
- Testing
- stool softener, Arm B: Acupressure bracelet, sugar free gum
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Nebraska
Hepatocellular Carcinoma
Effect of Adjuvant Therapy by Sorafenib, Oxaliplatin and S-1
The study is designed to investigate the effect of adjuvant therapy by Sorafenib, Oxaliplatin and S-1 to prevent the tumor recurrence for hepatocellular carcinoma after liver transplantation
- Trial name
- NCT02129322
- Testing
- Sorafenib, S-1, Oxaliplatin
- Where
- China
- Sponsor
- Zhejiang University
Hepatic and Hepatobiliary Disorders
Indocyanine Green Clearance Test in Liver Transplantation (LivInG)
The gap between patients awaiting and those undergoing liver transplantation (LT) continues to grow. Marginal organs carry higher risk of failure after LT however they are increasingly used to fill such gap.
- Trial name
- LivInG (NCT05228587)
- Testing
- Indocyanine green
- Where
- Italy
- Volunteers
- 162 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
End Stage Liver DIsease, Chronic Liver Failure
The Early Strength Training Program in Post-transplant Liver Cases
Liver transplantation (LT) is a current life-saving procedure performed as an open-abdominal surgery for patients with end-stage liver diseases (ESLD).
- Conditions
- End Stage Liver DIsease, Chronic Liver Failure, Liver Transplant Disorder, Muscle Loss
- Trial name
- NCT04546048
- Testing
- Strength Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Memorial Hospital Groups
Renal Function, Liver Transplant
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.
This study was designed to assess the evolution of renal function and to collect efficacy, safety, and tolerability data of everolimus in co-exposure with reduced CNI in paediatric liver transplant recipients.
- Trial name
- NCT01598987
- Testing
- Introduction of everolimus with reduced cyclosporine or tacrolimus dose, the earliest 1 month and the latest 6 months after liver transplantation.
- Where
- 32 sites in United States, Australia and 10 more
- Volunteers
- 56 people
- Sponsor
- Novartis Pharmaceuticals
Liver Disease, Fungal Infection
Anidulafungin vs Amphotericin B Safety in High Risk Hepatic Transplant Recipients
The study is a randomized, open-label safety study comparing the use of anidulafungin (200 mg i.v. as initial dose and 100 mg/d i.v.
- Trial name
- AVALTRA (NCT01303549)
- Testing
- Anidulafungin, Liposomal amphotericin B
- Where
- 12 sites in Spain
- Volunteers
- 61 people
- Sponsor
- Fundacion SEIMC-GESIDA
Liver Transplantation, Low-weight Children
Outcomes of Liver Transplantation in Low Weight Children After Reducing the Lateral Segment of a Living Donor, Adapting the Shape and Size of the Graft to the Needs of the Recipient
The shortage of organs has always been a problem in pediatric liver transplants due to the lack of donors with an adequate size.
- Conditions
- Liver Transplantation, Low-weight Children, Hyper-reduced Liver Grafts
- Trial name
- NCT03594864
- Testing
- Liver transplantation with hyper-reduced grafts
- Where
- Argentina
- Volunteers
- 58 people
- Sponsor
- Hospital Italiano de Buenos Aires
Liver Transplantation, Pain Management
Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors
Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes.
- Trial name
- NCT07123740
- Testing
- Intrathecal Morphine, Bi-level Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Liver Transplantation, Living Donor
Rectus-Intercostal Fascial Plane Block for Liver Transplantation Donors
Postoperative pain control plays a crucial role in enhancing recovery and improving early mobilization in living liver donors. The rectus-intercostal fascial plane (RIFP) block is a novel ultrasound-guided regional anesthesia…
- Conditions
- Liver Transplantation, Living Donor, Postoperative Pain
- Trial name
- NCT07233096
- Testing
- Rectus Intercostal Plane Block, Control (No Block)
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Istinye University
Vitamin D Deficiency, Hepatocellular Carcinoma
The Effect of Vitamin D Repletion in Patients With Hepatocellular Carcinoma on the Orthotopic Liver Transplant List
The purpose of this study is to investigate the effect of two different doses of vitamin D3 (2000 IU vs. 4000 IU) on serum 25-hydroxyvitamin D (25OHD) levels in patients with hepatocellular carcinoma on the liver transplant list.
- Trial name
- NCT01575717
- Testing
- Vitamin D3 4000 IU, Vitamin D3 2000 IU
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Andrea Branch
Liver Disease
Evaluation of EV1000™/volumeView™ for Cardiac Output Monitoring in Liver Transplantation
The investigators are trying to evaluate the agreement of cardiac output measurements taken using the specific thermistor-tipped arterial catheter ( the VolumeView ™ catheter) and the EV1000 ™ monitoring platform ( Edward…
- Trial name
- NCT02306018
- Testing
- EV1000™/volumeView™
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Samsung Medical Center
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Myocardial Perfusion Imaging, Liver Failure
Myocardial Perfusion Imaging in Liver Transplantation Candidates
The optimal screening strategy for assessment of coronary artery disease in patients with end-stage liver disease (ESLD) is unclear.
- Trial name
- ExSPECT (NCT03864497)
- Testing
- Myocardial perfusion imaging
- Volunteers
- 403 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Liver Transplantation
To Evaluate the Efficacy and Safety of ADVAGRAF® After Treatment With a Tacrolimus in New Liver Transplant Recipients
This study's objective is to evaluate the incidence rate of acute rejection reactions after 24 weeks treatment with ADVAGRAF® following 3 months treatment with tacrolimus in new liver transplant recipients.
- Trial name
- NCT03423225
- Testing
- ADVAGRAF®
- Volunteers
- 31 people
- Sponsor
- Kim, Seoung-Hoon
MRI Scans
Quantitative Susceptibility Mapping (QSM) to Guide Iron Chelating Therapy
The overall goal of this research is to help develop a new magnetic resonance (MR) method, Quantitative Susceptibility Mapping (QSM), to improve the measurement of liver iron concentrations without the need for a liver biopsy.
- Trial name
- NCT04171635
- Testing
- Quantitative Susceptibility Mapping (QSM) Magnetic Resonance Imaging (MRI), R2* Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Liver Transplant; Complications, Neurologic Complication
Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation
Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation.
- Conditions
- Liver Transplant; Complications, Neurologic Complication, Postoperative Complications
- Trial name
- NCT04188717
- Volunteers
- 253 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Transplanatation
Remote Ischemic Preconditioning in Liver Transplantation
Remote (upper arm) ischemic preconditioning in the donor of living donor liver transplanta to ameliorate the effect of reperfusion injury in recipients.
- Trial name
- RIRI (NCT02534025)
- Testing
- Ischemia preconditioining
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Alcohol Related Liver Disease, Orthotopic Liver Transplantation
Risk and Protective Factors for Relapse to Alcohol Use in Patients With Liver Disease Undergoing Liver Transplantation
This is an observational, monocentric study, consisting of both a retrospective and a prospective component. The aim of the study is to identify risk and protective factors for alcohol relapse in patients with alcohol-related…
- Trial name
- NCT06749990
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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