Clinical trials: Liver Transplants
Living Donor Liver Transplantation
A Comparison of Invasive and Non-invasive Measurement of CI and SVR in Liver Transplantation
Patients who are scheduled to receive living donor liver transplantation will be monitored with a radial and femoral arterial line.
- Trial name
- NCT04909645
- Testing
- Clearsight (finger cuff)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Liver Diseases
Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery
We compared the time consumed for goal-directed management of hypofibrinogemia using two strategies during liver transplant (LT) surgery: a conventional cryoprecipitate-based strategy versus a lyophilized fibrinogen…
- Trial name
- NCT06144112
- Testing
- fresh frozen plasma, prothrombin complex concentrate
- Where
- South Korea
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Ischemic-type Biliary Lesions
Mesenchymal Stem Cells Transplantation for Ischemic-type Biliary Lesions
Ischemic-type biliary lesions (ITBLs) are a major cause of graft loss and mortality after orthotopic liver transplantation (OLT). For now, there are still lacking effective treatment for ITBLs.
- Trial name
- NCT02223897
- Testing
- huc-MSCs
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Yang Yang
Liver Transplant
Interest of the Donor-specific Antibodies After Liver Transplantation
The study is a prospective observational mono center study Primary objective : Study the anti-HLA antibodies frequency preformed before liver transplantation and the kinetic of appearance of DSA and de novo complement-binding…
- Trial name
- vaLIDLIver (NCT03238443)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Lille
Liver Diseases, Kidney Diseases
Clinical Trial of New Hypothermic Oxygenated Perfusion System Versus Static Cold Storage
With the present study the investigators will evaluate the benefit of end-ischemic HOPE on ECD grafts (livers and kidneys) as compared to SCS.
- Trial name
- NCT03837197
- Testing
- Kidney-Hypothermic oxygenated, Liver-Hypothermic oxygenated
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- University of Bologna
Liver Transplant; Complications
Antithrombin III Concentrate After Liver Transplantation
This study was designed to demonstrate more effective administration method of AT-III in immediate post-liver transplantation period.
- Trial name
- NCT04219579
- Testing
- Antithrombin III, continuous infusion, Antithrombin III, Intermittent infusion
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Seoul National University Hospital
Sarcopenic Obesity
Sarcopenic Obesity in Liver Transplanted Patients
The prevalence of obesity in cirrhotic patients who are candidates for liver transplantation (LT) is increasing, a phenomenon consistent with the increased prevalence of obesity in the general population.
- Trial name
- OSaLT (NCT05029713)
- Testing
- Evaluation of appendicular skeletal muscle mass (ASMM) by bioelectrical impedance analysis (BIA)
- Where
- 2 sites in Italy
- Volunteers
- 400 people
- Sponsor
- University of Bari
Liver Transplant Disorder, Quality of Life
Validity and Reliability of the Turkish Version of the Post-Liver Transplant Quality of Life Questionnaire
Liver transplantation is a crucial treatment for life-threatening liver diseases, including acute liver failure, end-stage chronic liver disease, primary liver cancers, and congenital metabolic disorders.
- Trial name
- NCT06577480
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Hacettepe University
Liver Transplant; Complications
Brain Protection Effect of Selective Head Cooling and Dexmedetomidine in Patients Undergoing Liver Transplantation
The investigators investigated in the present study whether selective head cooling and dexmedetomidine has an effect on cerebral oxygenation during liver transplantation and has cerebral protective effect in patients undergoing…
- Trial name
- NCT03102359
- Testing
- Dexmedetomidine, Cooling Helmet
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huazhong University of Science and Technology
Hospital Hyperglycemia, Post-transplant Hyperglycemia
Intensive Glycemic Management and Outcomes Following Liver Transplantation
Most people develop high blood sugars following liver transplant that requires treatment with insulin in the hospital, even if they don't have diabetes, due to stress and use of steroid medications.
- Trial name
- NCT01432093
- Testing
- Intensive glycemic management, Conventional management
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Mayo Clinic
Liver Transplantation
Measurement of Gastrointestinal (GI) and Health-related Quality of Life (HRQL) Outcomes in Liver Transplant Recipients
Treatment with the immunosuppressive drug mycophenolate mofetil (MMF) may result in gastrointestinal (GI) complications in some patients.
- Trial name
- NCT00405652
- Testing
- Enteric-coated Mycophenolate sodium (EC-MPS)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Novartis Pharmaceuticals
Immunosuppression in Solid Organ Transplant
Belatacept in Liver Transplant Recipients
The purpose of this clinical research study is to evaluate the effects of belatacept, relative to tacrolimus, on the incidence of rejection, graft loss and death in subjects receiving a liver transplant
- Trial name
- NCT00555321
- Testing
- Tacrolimus, Basiliximab, Belatacept More Intensive (MI)
- Where
- 42 sites in United States, Argentina and 7 more
- Volunteers
- 260 people
- Sponsor
- Bristol-Myers Squibb
Liver Transplant Surgery
Benefits of Pulmonary Rehabilitation to Patients Post Liver Transplant
The goal of this clinical trial was to access the benefits of a 12-week home-based pulmonary rehabilitation regimen on pulmonary function recovery in post-liver transplant patients.
- Trial name
- NCT06606184
- Testing
- Inspiratory muscle Training, Routine Care
- Where
- Taiwan
- Volunteers
- 78 people
- Sponsor
- Chang Gung University
Pediatric Liver Transplantation
Safety and Tolerance of Immunomodulating Therapy With Donor-specific MSC in Pediatric Living-Donor Liver Transplantation
Since the introduction of calcineurin-based immunosuppression, patient and graft survival in pediatric liver transplantation (LT) improved significantly.
- Trial name
- MYSTEP1 (NCT02957552)
- Testing
- Mesenchymal Stem Cells
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- University Hospital Tuebingen
Heart Transplantation, Liver Transplantation
Organ Transplantation Rehabilitation: Effect of Bedside Exercise Device and Activity Reinforcement
The aims of this 3-year randomized, single-blinded clinical trial are to compare the effect of high and low feedback about performance on the bedside exercise device in heart or liver transplantation recipients during the…
- Trial name
- NCT01705015
- Testing
- direct feedback about exercise
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Taiwan University Hospital
Behavior and Behavior Mechanisms
Peers for Promoting Adolescent Transplant Health
Adolescents with solid organ transplants have poorer outcomes than adults, and do not respond as well to post-rejection treatment.
- Trial name
- Peers4PATH (NCT01450033)
- Testing
- Peer Mentoring, e-Communication with mentor
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Hospital of Philadelphia
Kidney Transplant; Complications, Liver Transplant; Complications
Medicine Adherence and Effects on Transplants With Pilloxa's Electronic Pillbox
Poor adherence to medication among patients with chronic diseases is a major problem. A patient group where the adherence to prescribed medications is extremely important are organ transplanted patients.
- Trial name
- NCT03848585
- Testing
- Pilloxa Pillbox, Non active Pilloxa Pillbox
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Pilloxa
Liver Transplantation
Comparing Montiroing Cardiac Index by Transpulmonary Thermodilution and Transesophageal Echocardiography During Liver Transplantation
Liver transplantation poses challenges due to hemodynamic changes throughout different surgical phases. Monitoring devices are essential for therapeutic adjustments.
- Trial name
- NCT06899867
- Testing
- Measure of cardiac index with thermodilution and transesophageal echocardiography, Surgical anastomosis echography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Cirrhosis, Hepatocellular Carcinoma
Microbiota Study in Liver Transplanted Patients
Many studies describe the relationship between microbiota alteration and the occurrence of metabolic, alcoholic or inflammatory liver diseases.
- Conditions
- Cirrhosis, Hepatocellular Carcinoma, Liver Transplant, Microbiota
- Trial name
- BIM-LT (NCT03507140)
- Testing
- Multiple sampling
- Where
- France
- Volunteers
- 64 people
- Sponsor
- University Hospital, Grenoble
Liver Cirrhosis
Effect of Saccharomyces Boulardii in Patients in the Waiting List for Liver Transplant
The purpose of this study is to evaluate the effect of Saccharomyces boulardii in patients in the waiting list for liver transplant.
- Trial name
- NCT01762748
- Testing
- Saccharomyces boulardii
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
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