Clinical trials: Liver Transplants
Liver Transplantation, Physical Fitness
A Home-based Exercise and Physical Activity Intervention After Liver Transplantation: Impact of Exercise Intensity
Research demonstrated that transplant recipients benefit from physical activity, but there is a gap in knowledge regarding the required intensity.
- Trial name
- PHOENIX-L (NCT06302205)
- Testing
- Physical activity
- Where
- Belgium
- Volunteers
- 147 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Transplantation
Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension
The objective of this observational study is to compare the safety profile of auxiliary liver transplantation using small-for-size grafts with that of conventional liver transplantation and to evaluate the efficacy of this…
- Trial name
- NCT07247877
- Volunteers
- 396 people
- Sponsor
- Zhi-Jun Zhu
Immune Tolerance, Immunosuppression
Efficacy and Safety of Immunosuppressive Withdrawal After Pediatric Liver Transplantation
The goal of this clinical trial is to learn about the efficacy and safety of immunosuppressive withdrawal in pediatric liver transplant recipients.
- Conditions
- Immune Tolerance, Immunosuppression, Liver Transplant; Complications
- Trial name
- NCT06147375
- Testing
- Tacrolimus or Cyclosporine A
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Wei Gao
Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney
The Effect of Remote Ischemic Postconditioning on Liver Graft and Renal Function in Patients Undergoing Living-related Liver Transplantation
The investigators are trying to evaluate the clinical effect of remote ischemic postconditioning on liver graft function and postoperative renal function in subjects undergoing living-donor liver transplantation.
- Conditions
- Ischemia/Reperfusion Injury of Liver Graft, Ischemia/Reperfusion Injury of Kidney, Remote Ischemic Postconditioning
- Trial name
- NCT01637038
- Testing
- RIPC
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Samsung Medical Center
Liver Metastasis, Colorectal Cancer
Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases Treated by Chemotherapy
This is a multicentric randomized parallel group open trial comparing 5-year survival of chemotherapy followed by LT (Group LT+C) versus chemotherapy alone (Group C) in patients with confirmed unresectable liver-only metastases…
- Conditions
- Liver Metastasis, Colorectal Cancer, Metastasis
- Trial name
- TRANSMET (NCT02597348)
- Testing
- Liver Transplantation
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplantation
A Study to Compare Safety and Efficacy of Prograf + Myfortic and Advagraf + Myfortic in Liver Transplantation Patients
To compare the safety and efficacy of Prograf® with Myfortic® to Advagraf® extended release tacrolimus with Myfortic® in de novo liver transplant recipients.
- Trial name
- NCT01018914
- Testing
- Prograf, Advagraf, Myfortic
- Where
- 3 sites in Taiwan
- Volunteers
- 44 people
- Sponsor
- Astellas Pharma Inc
Hepatocellular Carcinoma, Scirrhous, Recurrence Tumor
HepatoPredict Prognostic Tool for the Decision of Liver Transplant in Hepatocellular Carcinoma
Liver transplant is the most effective treatment for hepatocellular carcinoma (HCC) in cirrhosis. Due to organs shortage, the proper selection of patients is imperative.
- Trial name
- HepatoPredict (NCT04499833)
- Testing
- liver transplant
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Kidney Transplant, Liver Transplant
Examining the Use of a Novel Immersive Motion Tracking Upper Extremity Exercise Program for Acute Hospitalized Patients
The objective of this study is to evaluate the feasibility of the MoveMend Health software program as an integrated supplement to traditional acute care/in-hospital occupational therapy for patients following liver and kidney…
- Trial name
- NCT06222554
- Testing
- MoveMend Health
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- NYU Langone Health
HIV Infection, Liver Transplant
Expanding HOPE Liver
This is a prospective, multicenter clinical study. The objective is to determine whether a liver transplant from a deceased donor with HIV is associated with an increased risk of opportunistic infection and cancer.
- Trial name
- NCT07778459
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Transplantation
Study of the Effect of Everolimus Immunosuppressive Combination Therapies on Renal Function When Used as a Maintenance Treatment for Liver Transplant Patients.
A 24-month multi-center, open-label, randomized, controlled study to evaluate the evolution of renal function in maintenance liver transplant recipients receiving everolimus plus reduced TAC or everolimus plus mycophenolate…
- Trial name
- Prometheus (NCT03596970)
- Testing
- TAC withdrawal, Everolimus with reduced TAC
- Sponsor
- Novartis Pharmaceuticals
Liver Transplantation, Kidney Transplantation
Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic Therapy
We hypothesize that delayed graft function and ITBS events may be related to small blood clots (microthrombi) that collect in the kidneys and liver after cardiac death.
- Trial name
- NCT01197573
- Testing
- rTPA Treatment, No TPA Treatment
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- The Cleveland Clinic
Liver Transplant; Complications
Brain Protection Effect of Selective Head Cooling and Dexmedetomidine in Patients Undergoing Liver Transplantation
The investigators investigated in the present study whether selective head cooling and dexmedetomidine has an effect on cerebral oxygenation during liver transplantation and has cerebral protective effect in patients undergoing…
- Trial name
- NCT03102359
- Testing
- Dexmedetomidine, Cooling Helmet
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huazhong University of Science and Technology
Asses Immunosuppression Modulation on Renal Recovery Post LT
Examination of Immunosuppression Adjustment Impact on Kidney Function in Liver Transplant
This is a study to help understand how well new combinations of immunosuppressive medications (medications that weaken your immune system to prevent your body from rejecting the transplanted liver) work compared to standard…
- Trial name
- NCT04104438
- Testing
- Basiliximab 20 MG
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Fady M Kaldas, M.D., F.A.C.S.
Liver Transplantation
Early Conversion of Prolonged-release Tacrolimus in Liver Transplantation.
Tacrolimus is a commonly used immunosuppressant after liver transplantation. A once-daily administration of prolonged-release tacrolimus has been found to improve patient compliance and offer good efficacy and safety.
- Trial name
- NCT06147648
- Testing
- Tacrolimus Sustained-release Capsules
- Volunteers
- 352 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Graft Vs Host Disease
Evaluation of the Impact of Reduced Immunosuppression
Graft-versus-host disease (GVHD) is a life-threatening complication of transplantation. It occurs when the donor graft contains immunologically competent T-cells that recognize the recipient as foreign.
- Trial name
- NCT05238155
- Testing
- antimetabolite
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Methodist Health System
Liver Transplant; Complications, Ischemic Cholangiopathy
Seladelpar in Adult Liver Transplant Recipients With Ischemic Cholangiopathy (SELIC).
A prospective, open-label, single-arm, investigator-initiated study (SELIC) to evaluate the efficacy and safety of seladelpar in adult liver transplant recipients with Ischemic cholangiopathy (IC).
- Trial name
- SELIC (NCT07305363)
- Testing
- Seladelpar
- Volunteers
- 10 people
- Sponsor
- University of California, San Diego
Alcohol Use Disorder, Liver Transplant; Complications
Safety of Acamprosate in Treating Alcohol Use Disorder in the Post Liver Transplant Populations
Acamprosate for alcohol use disorder may benefit liver transplant (LT) recipients with alcohol-associated liver disease (ALD), yet data on feasibility and safety in LT recipients are lacking.
- Trial name
- NCT06471686
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Southern California
Liver Metastases, Colorectal Cancer
Liver Transplantation Compared to Chemotherapy in Patients With ColoRectal Cancer
The trial is a randomized control trial. Patients are randomized between Ltx and other treatment that may include further chemotherapy, TACE, SIRT or other available treatment options.
- Trial name
- SECAIII (NCT03494946)
- Testing
- Liver transplantation, Chemotherapy
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Hepatocellular Carcinoma
Effects of Statin on Hepatocellular Carcinoma Recurrence After Liver Transplantation
This study aims to investigate whether statin therapy can help prevent recurrence of hepatocellular carcinoma (HCC) in transplant recipients who had liver transplantation for HCC.
- Trial name
- NCT03490461
- Testing
- Statin
- Where
- South Korea
- Volunteers
- 350 people
- Sponsor
- Yonsei University
Liver Transplantation
Long-term Outcomes After Prolonged Dual Hypothermic Oxygenated Machine Perfusion of Donor Livers (DHOPEPROLONG)
End-ischemic dual hypothermic oxygenated machine perfusion (DHOPE) of human donor livers mitigates ischemia-reperfusion injury, resulting in a reduction of post-reperfusion syndrome, early allograft dysfunction and biliary…
- Trial name
- DHOPEPROLONG (NCT05680246)
- Testing
- DHOPE-PRO
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- University Medical Center Groningen
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