Clinical trials: Liver Transplants
Liver Transplantation, Pain Management
Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors
Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes.
- Trial name
- NCT07123740
- Testing
- Intrathecal Morphine, Bi-level Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Biliary Stricture
WallFlex Biliary Fully Covered (FC) Benign Stricture Study
The purpose of this study is to evaluate the safety and performance of the WallFlex® Biliary RX Fully Covered Stent as a treatment of biliary obstruction resulting from benign bile duct strictures.
- Trial name
- NCT01014390
- Testing
- WallFlex Biliary RX Fully Covered Stent System
- Where
- 13 sites in Australia, Austria and 9 more
- Volunteers
- 187 people
- Sponsor
- Boston Scientific Corporation
Liver Transplant Disorder, HCC
Equity and Efficacy of Allocation Priority for Liver Transplantation Patients With MELD≥30 in Italy
In Italy, since August 2014, liver transplantation (LT) candidates with MELD≥30 receive a priority allocation consenting them to access in an organ sharing macroarea.
- Trial name
- NCT04530240
- Testing
- Liver Transplantation
- Volunteers
- 4,238 people
- Sponsor
- University of Bologna
Liver Transplant
Multicenter Study on Organ Acquisition Costs in the Post Re-Allocation Era: Liver Transplantation
Organ procurement organizations (OPO) have increased organ recovery efficiency and yield and have also reduced organ acquisition charges.
- Trial name
- NCT05087550
- Testing
- Liver Transplantation
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Methodist Health System
Liver Transplantation
The Validity of Central Venous to Arterial Co2 Difference During Living Donor Liver Transplantation
Study will be conducted on 20 patients ASA III-IV undergoing orthotopic liver transplantation. Blood samples will be obtained simultaneously from arterial line, pulmonary artery catheter and central venous catheter at 4 specific…
- Trial name
- NCT03123172
- Testing
- arterial and central venous blood gases
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kasr El Aini Hospital
Liver Transplant; Complications
POstoperative Negative-pressure Incision Therapy Following LIver TRANSplant:a Randomized Controlled Trial
This study is to evaluate whether the prophylactic use of a negativa pressure therapy device (PICOⓇ) on the closed wound of the liver transplant, reduces the postoperative complications of surgical wounds, compared to the use of…
- Trial name
- PONILITRANS (NCT04039659)
- Testing
- Negative-pressure wound therapy (PICO)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Liver Transplantation
Validity of Different Prognostic Models Assessing 1 Year Survival After Liver Transplantation
Validity of MELD vs MELD XI in assessing 1 year survival after living donor liver transplantation.
- Trial name
- ProgModels (NCT02412280)
- Testing
- retrospecive observational
- Volunteers
- 200 people
- Sponsor
- Mansoura University
Transplant;Failure,Kidney, Transplant; Failure, Liver
Leveraging Technology to Improve Medication Adherence in Youth With Kidney or Liver Transplant
Can the investigators create an effective way to improve adherence to immunosuppressant medication and reduce rejection, graft loss, and death in adolescents and young adults who have undergone kidney or liver transplantation?…
- Conditions
- Transplant;Failure,Kidney, Transplant; Failure, Liver, Adherence, Medication, Adherence, Patient
- Trial name
- NCT05613010
- Testing
- mHealth Messaging Intervention Group
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Johns Hopkins University
Liver Transplant
Cyclosporine A C-2h Monitoring Versus Tacrolimus C-0h Monitoring in de Novo Liver Transplant Recipients
The purpose of this study is to determine whether cyclosporine A (in a micro emulsion formulation) monitored by sample taken 2 hour after oral dose (C-2h) will show equivalent or superior efficacy compared to tacrolimus monitored…
- Trial name
- NCT00149994
- Testing
- Cyclosporine A, Tacrolimus, Basiliximab
- Where
- Switzerland
- Volunteers
- 171 people
- Sponsor
- Novartis Pharmaceuticals
Transplantation
A Conversion Study to Assess Safety and Efficacy of a MR4 Based Immunosuppressive Regimen in Stable Liver Recipients
Assessment of the safety and the efficacy of a tacrolimus modified release (MR4) based immunosuppressive regimen in stable liver transplant subjects converted on a 1:1 (mg:mg) basis from a Prograf® based immunosuppressive regimen.
- Trial name
- NCT00384202
- Testing
- Tacrolimus
- Where
- 13 sites in France, Germany and 4 more
- Volunteers
- 112 people
- Sponsor
- Astellas Pharma Inc
Acute-On-Chronic Liver Failure, Liver Cirrhosis
Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study
The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology.
- Conditions
- Acute-On-Chronic Liver Failure, Liver Cirrhosis, Liver Transplant; Complications
- Trial name
- TEA-ACLF (NCT05036031)
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Medication Adherence, Liver Transplant Disorder
Text Messages for Liver Transplant Recipients
Although medical advancements have enabled children experiencing liver transplants to live longer, medical management post-transplant is ongoing and complex.
- Trial name
- NCT04995770
- Testing
- Praise Text Messages
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Children's Hospital Los Angeles
Hepatocellular Carcinoma
Lenvatinib Following Liver Transplantation in Patients With High-Risk Hepatocellular Carcinoma
The aim of this study is to observe the efficacy and safety of lenvatinib in preventing high-risk recurrence of hepatocellular carcinoma patients after liver transplantation.The cases are from patients with hepatocellular…
- Trial name
- NCT04168944
- Testing
- Lenvatinib, Immunosuppressive regimen
- Volunteers
- 108 people
- Sponsor
- RenJi Hospital
Biliary Atresia
Pentoxifylline Therapy in Biliary Atresia
The purpose of this study is to determine whether pentoxifylline reduces liver damage in infants with biliary atresia.
- Trial name
- NCT01774487
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Baylor College of Medicine
Hepatocellular Carcinoma
Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant
A single institution, single arm, two-cohort feasibility trial to evaluate the combination of locoregional Y^90 therapy with systemic atezolizumab and bevacizumab, in participants presenting with hepatocellular carcinoma (HCC) 1)…
- Trial name
- NCT07059494
- Testing
- Atezolizumab, Bevacizumab, Y^90 Radioembolization
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Liver Transplant, Fungal Infection
An Assessment of Voriconazole Pharmacokinetics and Pharmacogenetics in Liver Transplant Recipients - Pilot Study
A fixed-dosing regimen of voriconazole is routinely used as prophylaxis against aspergillosis in liver transplant patients admitted to the transplant intensive care unit at UPMC.
- Trial name
- NCT00371605
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Liver Transplant Recipients
Conversion From Sirolimus to Everolimus in the Maintenance Treatment of Liver Transplant Recipients
This study aims to determine the safety and efficacy of conversion of sirolimus to everolimus in the maintenance treatment of LT recipients. Patients will be monitored every 12 weeks after the switch of treatment for 48 weeks.
- Trial name
- NCT02482974
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ege University
Transplant
Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00436384
- Testing
- Monitoring-blood samples drawn for CMV testing
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma, Portal Vein Tumor Thrombus
Lenvatinib Following Liver Transplantation in Patients of Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
The aim of this study is to observe the efficacy and safety of lenvatinib in preventing recurrence of hepatocellular carcinoma patients with portal vein tumor thrombus after liver transplantation.
- Conditions
- Hepatocellular Carcinoma, Portal Vein Tumor Thrombus, Liver Transplantation
- Trial name
- LLTHVV (NCT04319484)
- Testing
- lenvatinib
- Volunteers
- 108 people
- Sponsor
- RenJi Hospital
Liver Disease, Liver Neoplasms
Orthotopic Liver Transplantation Using a Living Donor
The purpose of this study is to: determine the safety of donor right hepatic lobectomy as a procedure to provide a liver graft for living donor liver transplantation.
- Trial name
- NCT00152607
- Testing
- donor right hepatic lobectomy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
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