Clinical trials: Liver Tumour
Hepatocellular Carcinoma
Dynamic Contrast-enhanced Magnetic Resonance Imaging in Evaluation of Liver Functional Status and Treatment Efficacy in Patients With Hepatocellular Carcinoma After Locoregional Therapy
Hepatocellular carcinoma (HCC) is a major health problem worldwide. For patients with intermediate-stage disease, i.e., large or multifocal HCC without vascular invasion or extrahepatic spread, transarterial chemoembolization…
- Trial name
- NCT01281683
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Liver Cancer
Biomarkers in Stored Tumor Samples From Younger Patients With Liver Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899002
- Testing
- comparative genomic hybridization, molecular genetic technique, mutation analysis
- Sponsor
- Vanderbilt-Ingram Cancer Center
HCC, Hepatocellular Carcinoma
Clinical Pharmacogenetic Study of Sorafenib in Egyptian Patients With Hepatocellular Carcinoma
The current study will aim to maximize the therapeutic effect and to minimize the adverse effects of sorafenib in HCC through pharmacogenomic analysis of VEGFA and KDR genetic polymorphisms.
- Trial name
- NCT06527495
- Testing
- Sorafenib
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Melanoma, Breast Cancer
Safety Study of Modified Vaccinia Virus to Cancer
The purpose of this study is to determine the safety and maximum tolerated dose from injecting this vaccinia virus into tumors or infusion.
- Conditions
- Melanoma, Breast Cancer, Head and Neck Squamous Cell Cancer, Liver Cancer
- Trial name
- NCT00574977
- Testing
- Vaccinia virus (vvDD-CDSR)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- David Bartlett
Hepatocellular Cancer, Gastrointestinal Cancer
Investigation of Immune Modulation by Modern Acupuncture in Gastroenterologic Cancers
According to the total population of cancer patients, hepatocellular carcinoma (HCC) and colorectal cancer (CRC), two of gastroenterological cancers are involved in the most acquired five cancers.
- Conditions
- Hepatocellular Cancer, Gastrointestinal Cancer, Immunosuppression
- Trial name
- NCT04692454
- Testing
- Modern acupuncture
- Where
- Taiwan
- Volunteers
- 5 people
- Sponsor
- Taipei Medical University WanFang Hospital
Infections, Coronavirus, Kidney Transplantation
COVID-19 in Immunosuppressed Children
Viral respiratory infections are common infectious complications after kidney transplantation, especially in the pediatric age group, and immunosuppressed patients may develop more severe disease.
- Conditions
- Infections, Coronavirus, Kidney Transplantation, Liver Transplantation, Cancer
- Trial name
- NCT04511429
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- D'Or Institute for Research and Education
Hepatocellular Carcinoma, COVID-19
COVID-19 Infection in Patients With Hepatocellular Carcinoma
Since December 2019, a new disease named COVID-19 linked to a new coronavirus, SARS-CoV2 has emerged in China in the city of Wuhan, Hubei province, spreading very quickly to all 5 continents, and responsible for a pandemic.
- Trial name
- COVID19-CHIEF (NCT04367805)
- Testing
- nasopharyngeal Covid 19 RT-PCR
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Refractory Neoplasms
Effectivity and Safety of Irreversible Electroporation for Refractory Neoplasms in Liver and Pancreas
The pupose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for refractory neoplasms in liver and pancreas, the investigators used preoperative and postoperative US/CEUS/CT/MRI to assess…
- Trial name
- NCT02822066
- Testing
- Electroporation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hepatitis C Infection, Viruses
Civacir® Polyclonal Immune Globulin (IgG) to Prevent Hepatitis C Virus (HCV) Recurrence in Liver Transplant Patients.
The purpose of this study is to test the safety and efficacy of Civacir® to prevent the recurrence of Hepatitis C Virus (HCV) after liver transplant.
- Conditions
- Hepatitis C Infection, Viruses, Hepatocellular Carcinoma, Hepatitis, Viral, Human
- Trial name
- NCT01804829
- Testing
- Civacir® 10%
- Where
- 23 sites in United States
- Volunteers
- 80 people
- Sponsor
- Biotest Pharmaceuticals Corporation
Hepatic Neoplasms
Identification of Hepatic Lesions
Patients with suspicion of primary or secondary hepatic malignancy in whom a radiological examination is needed in order to decide on the most appropriate treatment.
- Trial name
- NCT00307866
- Testing
- Resovist (BAY86-4884, SH U 555 A)
- Where
- 19 sites in Italy
- Volunteers
- 218 people
- Sponsor
- Bayer
Hepatocellular Cancer
A Longitudinal Observational Study of the Natural History and Management of Patients With HCC
TARGET-HCC is a longitudinal, observational study of patients being managed for HCC in usual clinical practice. TARGET-HCC will create a research registry of participants with HCC within academic and community real-world…
- Trial name
- NCT02954094
- Where
- 71 sites in United States, France and 3 more
- Volunteers
- 10,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Hepatocellular Carcinoma
Sorafenib With TACE to Treat Hepatocellular Carcinoma
The purpose of this study is to determine the feasibility to combine sorafenib with transarterial chemoembolisation in patients suffering from hepatocellular carcinoma.The hypothesis is that sorafenib may prevent the development…
- Trial name
- S-TACE (NCT00478374)
- Testing
- Sorafenib, Transarterial chemoembolisation with doxorubicin
- Where
- Switzerland
- Volunteers
- 21 people
- Sponsor
- University of Bern
Hepatic Cancer
Direct Peritoneal Resuscitation Plus Conventional Resuscitation
The purpose of this study is to find out if direct peritoneal resuscitation (DPR) (putting a sugar solution into the abdominal cavity) helps blood flow through vital organs in the body that may suffer from low blood flow due to…
- Trial name
- NCT01882218
- Testing
- Galactose, Standard Treatment
- Where
- 2 sites in United States
- Sponsor
- University of Louisville
Liver Fibroses, HepatoCellular Carcinoma
Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment
Primary Objective: To evaluate the long-term outcomes including liver related morbidity, mortality and hepatocellular carcinoma (HCC) development as compared to those of historical control with interferon(IFN)-based treatment.
- Conditions
- Liver Fibroses, HepatoCellular Carcinoma, Cryoglobulinemia, Metabolic Disease
- Trial name
- LONGHEAD (NCT03042520)
- Testing
- Observation only
- Where
- 26 sites in South Korea, Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Hepatocellular Carcinoma, Liver Neoplasms
A Phase II Single-Arm Clinical Study to Evaluate the Efficacy and Safety of Carbon Ion Radiotherapy With Atezolizumab and Bevacizumab Combination Therapy in Patients With Advanced Hepatocellular Carcinoma
This single-center, prospective phase II clinical trial evaluates the safety and therapeutic efficacy of combining carbon ion radiotherapy with the standard first-line regimen of atezolizumab and bevacizumab in patients with…
- Conditions
- Hepatocellular Carcinoma, Liver Neoplasms, Carcinoma, Hepatocellular
- Trial name
- NCT07246668
- Testing
- Carbon Ion Radiotherapy Atezolizumab Bevacizumab
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Yonsei University
Hepatocellular Carcinoma, Liver Cirrhosis
Liver and Spleen Stiffness to Predict the Presence of Esaphageal Varices in Cirrhotic With Advanced HCC
Elasto-HCC is a prospective, uncontrolled, multicenter observational study involving several hepatology centers in Italy. Patients with liver cirrhosis and advanced hepatocellular carcinoma (HCC) who will need to undergo systemic…
- Conditions
- Hepatocellular Carcinoma, Liver Cirrhosis, Portal Hypertension
- Trial name
- ELASTO-HCC (NCT06773260)
- Testing
- Liver and Spleen stiffness measurement.
- Where
- 12 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliero Universitaria Policlinico Modena
Fibrosis, Liver
Screening for Chronic Liver Diseases in General Population
Improving the care of patients with liver diseases in primary care and will allow patients with chronic liver disease to benefit from a course appropriate care.
- Trial name
- HEPGEN (NCT06366425)
- Testing
- Blood sample then fibroscan
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Montpellier
Hepatocellular Carcinoma
A Study to Evaluate the Efficacy and Safety of Sintilimab in Combination With IBI305 (Anti-VEGF Monoclonal Antibody) Compared to Sorafenib as the First-Line Treatment for Advanced Hepatocellular Carcinoma.
The purpose of the study is to assess the safety, tolerability and effectiveness of Sintilimab in combination with IBI305 in patients with HCC as the first-line treatment compared with Sorafenib.
- Trial name
- NCT03794440
- Testing
- Sintilimab, IBI305, Sorafenib
- Where
- China
- Volunteers
- 595 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Liver, Cancer of, Non-Resectable
QuiremSpheres Observational Study
The main purpose of this study is to further assess treatment efficacy and safety after using QuiremSpheres® for the treatment of patients with unresectable primary liver cancer or unresectable liver metastases suitable for SIRT…
- Trial name
- Hope166 (NCT03563274)
- Testing
- Selective Internal Radiation Therapy with QuiremSpheres®
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 20 people
- Sponsor
- Terumo Europe N.V.
Metastatic Malignant Neoplasm in the Liver, Pancreatic Neuroendocrine Tumor
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
This phase II trial studies the effect of capecitabine and temozolomide after surgery in treating patients with high-risk well-differentiated pancreatic neuroendocrine tumors.
- Conditions
- Metastatic Malignant Neoplasm in the Liver, Pancreatic Neuroendocrine Tumor, Stage I Pancreatic Neuroendocrine Tumor AJCC v8, Stage II Pancreatic Neuroendocrine Tumor AJCC v8
- Trial name
- NCT05040360
- Testing
- Capecitabine, Temozolomide
- Where
- 448 sites in United States, Mexico and 1 more
- Volunteers
- 141 people
- Sponsor
- SWOG Cancer Research Network
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