Clinical trials: Liver and Intrahepatic Biliary Tract Cancer
Liver Cancer, Renal Cancer
A Randomized Controlled Trial of the Safety and Efficacy of Robotic Telesurgery Versus Laparoscopic Surgery
This is a randomized controlled trial that will be preceded by a safety trial focusing on the safety and efficacy of robotic telesurgery.
- Conditions
- Liver Cancer, Renal Cancer, Rectal Cancer
- Trial name
- NCT06369597
- Testing
- Robotic telesurgery, Laparoscopic surgery
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Sun Yat-sen University
Liver Cirrhosis
Contrast-Enhanced Ultrasound Imaging in Diagnosing Liver Cancer in Patients With Cirrhosis
This clinical trial studies how well contrast-enhanced ultrasound imaging works in diagnosing liver cancer in patients with cirrhosis.
- Trial name
- NCT03318380
- Testing
- Dynamic Contrast-Enhanced Ultrasound Imaging
- Where
- 11 sites in United States, Canada and 4 more
- Volunteers
- 612 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Bevacizumab and Erlotinib in Treating Patients With Advanced Liver Cancer
This phase II trial is studying how well giving bevacizumab together with erlotinib works in treating patients with advanced liver cancer. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT00365391
- Testing
- bevacizumab, erlotinib hydrochloride
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Cancer Institute (NCI)
Liver Cancer, Liver Cirrhosis
International Study of High-Risk Patients for Hepatocellular Carcinoma Using Liquid Biopsy
This study has two purposes. One is to conduct a phase IV biomarker validation study in which the investigators will prospectively survey a cohort of patients at risk for liver cancer using semi-annual abdominal ultrasound and…
- Conditions
- Liver Cancer, Liver Cirrhosis, Hepatocellular Carcinoma, Early Stage Liver Cancer
- Trial name
- STOP-HCC (NCT05342350)
- Testing
- GALAD Score
- Where
- 10 sites in Saudi Arabia, Vietnam
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Liver Cancer
Epirubicin and Celecoxib in Treating Patients With Hepatocellular Carcinoma
RATIONALE: Celecoxib may stop the growth of tumor cells by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00057980
- Testing
- celecoxib, epirubicin hydrochloride
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwestern University
Advanced Liver Cancer
OH2 Oncolytic Viral Therapy Via Transcatheter Intraarterial Infusion in Patients with Advanced Liver Cancer
An open-label dose-escalation phase I clinical study to evaluate the safety, tolerability and pharmacokinetics of OH2 injection via transcatheter Intraarterial infusion in patients with advanced hepatocellular carcinoma
- Trial name
- NCT05698459
- Testing
- OH2 injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Binhui Biopharmaceutical Co., Ltd.
Liver Cancer
Phase 1 TheraSphere + Everolimus With Neuroendocrine Tumors (NETs) + Liver Only or Liver Dominant Disease
The goal of this clinical research study is to find the highest tolerable dose of the combination of everolimus with TheraSphere that can be given to patients with advanced NETs that have spread to the liver.
- Trial name
- NCT01864070
- Testing
- TheraSphere, Everolimus, Phone Call
- Sponsor
- M.D. Anderson Cancer Center
Liver Cancer, Biliary Tract Cancer
Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA.
- Conditions
- Liver Cancer, Biliary Tract Cancer, Pancreatic Cancer
- Trial name
- NCT06139042
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 1,608 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hepatocellular Carcinoma
Study of IMC-1121B (Ramucirumab) in Participants With Liver Cancer Who Have Not Previously Been Treated With Chemotherapy
A study to determine how long ramucirumab (IMC-1121B) will stop cancer from growing in participants with liver cancer that cannot be treated with surgery.
- Trial name
- NCT00627042
- Testing
- Ramucirumab (IMC-1121B)
- Where
- 6 sites in United States
- Volunteers
- 42 people
- Sponsor
- Eli Lilly and Company
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Sorafenib Tosylate in Treating Patients With Liver Cancer Who Have Undergone a Liver Transplant
This phase I trial studies the side effects and best dose of sorafenib tosylate in treating patients with liver cancer who have undergone a liver transplant.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Resectable Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer
- Trial name
- NCT00844168
- Testing
- sorafenib tosylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Washington
Metastatic Liver Cancer, Secondary Liver Cancer
Study Comparing Radio Frequency Ablation Plus Chemotherapy and Chemotherapy Alone in Patients With Secondary Liver Metastases
The purpose of this study is to determine whether patients treated with Radiofrequency Ablation (RFA) in conjunction with chemotherapy have a better overall survival rate than patients treated with chemotherapy alone.
- Conditions
- Metastatic Liver Cancer, Secondary Liver Cancer, Liver Neoplasm
- Trial name
- Prometheus (NCT00510627)
- Testing
- Radiofrequency Ablation (RFA), Chemotherapy
- Where
- 2 sites in United States
- Sponsor
- Boston Scientific Corporation
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Rebeccamycin Analogue in Treating Patients With Advanced Liver and/or Biliary Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of rebeccamycin analogue in treating patients who have…
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer
- Trial name
- NCT00005997
- Testing
- becatecarin
- Where
- 3 sites in United States
- Volunteers
- 72 people
- Sponsor
- Case Comprehensive Cancer Center
Liver Cancer
TAC-101 in Treating Patients With Advanced Hepatocellular Carcinoma (Liver Cancer)
RATIONALE: TAC-101 may stop the growth of cancer by stopping blood flow to the tumor. PURPOSE: This phase I/II trial is studying the side effects and best dose of TAC-101 and to see how well it works in treating patients with…
- Trial name
- NCT00077142
- Testing
- TAC-101
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- M.D. Anderson Cancer Center
NASH - Nonalcoholic Steatohepatitis
Novel MRE Technique to Assess a Risk Factor for Liver Cancer
The aim of this proposal is to investigate a novel imaging method to identify patients with non-alcoholic steatohepatitis (NASH) who are at risk for hepatocellular carcinoma (HCC).
- Trial name
- NCT05165446
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Natalie Torok
Liver Cancer, Hepatocellular Carcinoma
Lenvatinib Plus VIC-1911 in Lenvatinib-unresponsive or Lenvatinib-resistant HCC
This is a prospective clinical study aiming to test the safety and efficacy of lenvatinib in combination with Aurora kinase A inhibitor VIC-1911 in participate with lenvatinib-unresponsive or lenvatinib-resistant hepatocellular…
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Resistant Cancer
- Trial name
- NCT05718882
- Testing
- Lenvatinib Oral Product Plus VIC1911
- Where
- China
- Volunteers
- 5 people
- Sponsor
- RenJi Hospital
Hepatocellular Carcinoma
To Evaluate the Safety and Efficacy of Microwave Ablation Therapy in Patients With Primary Liver Cancer
Through the implementation of prospective, multi-center, single-group target value research to verify the safety and effectiveness of the microwave ablation treatment system for the ablation treatment of primary liver cancer.
- Trial name
- NCT04520906
- Testing
- microwave ablation
- Where
- 13 sites in China
- Volunteers
- 61 people
- Sponsor
- Suzhou Hengruihongyuan Medical Technology Co. LTD
Liver Cancer, Surgery
Nutrition and Exercise Prehabilitation to Reduce Morbidity Following Major Liver Surgery in Sarcopenic Patients
NEXPREM is a single-center non-blinded randomized controlled trial investigating preoperative exercise and nutrition for sarcopenic patients in major hepatic surgery for liver malignancies.
- Conditions
- Liver Cancer, Surgery, Sarcopenia
- Trial name
- NEXPREM (NCT05281211)
- Testing
- Nutrition, Exercise
- Where
- 2 sites in Italy
- Volunteers
- 70 people
- Sponsor
- San Camillo Hospital, Rome
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trial
This phase III trial compares the effect of immunotherapy (IO) with stereotactic body radiation therapy (SBRT) to IO alone in treating patients with liver cancer (hepatocellular cancer) that may have spread from where it first…
- Conditions
- Advanced Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8
- Trial name
- NCT07166406
- Testing
- Atezolizumab, Bevacizumab, Biospecimen Collection
- Where
- 139 sites in United States, Canada
- Volunteers
- 226 people
- Sponsor
- NRG Oncology
Liver Carcinoma, Hepatocellular Carcinoma
Combined HCC-MFCCC
Combined hepatocellular and mass-forming cholangiocarcinoma (cHCC-MFCCC) is a rare tumor. The aim of this study was the analysis of the outcome comparing such tumor with classic hepatocellular carcinoma (HCC) and mass-forming…
- Conditions
- Liver Carcinoma, Hepatocellular Carcinoma, Cholangiocarcinoma, Surgery
- Trial name
- NCT03178409
- Testing
- Hepatectomy
- Volunteers
- 100 people
- Sponsor
- University of Milan
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