Clinical trials: Local Anaesthesia
Postoperative Pain, Complications
A Trial of Closed Hemorrhoidectomy Under Local Perianal Block Versus Spinal Anesthesia
Hemorrhoidectomy can be carried out under several modes of anesthesia. In western country hemorrhoidectomy usually be performed under general anesthesia, however there may be the complications resulted from general anesthesia…
- Conditions
- Postoperative Pain, Complications, Satisfaction
- Trial name
- NCT00925912
- Testing
- spinal block, Perianal block
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Molar Incisor Hypomineralization, Anesthesia, Local
Effect of Silver Diamine Fluoride on Local Anesthesia in Hypomineralized Molars
The purpose of this randomized, controlled clinical study is to evaluate if application of 38% SDF increases the efficacy of local anesthesia during operative dentistry on permanent molars affected by molar-incisor hypoplasia…
- Trial name
- NCT05964387
- Testing
- SDF
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anesthesia; Reaction, Anesthesia
Efficacy and Safety of Prilocaine 2% and Lidocaine 5% Hyperbaric Against Spinal Anesthesia in Post Cystoscopy Procedure
Regional anesthesia is defined as the temporary removal of nerve conduction and pain in certain areas of the body with local anesthetic drugs without causing loss of consciousness.
- Trial name
- NCT05834647
- Testing
- Prilocaine 2%, Hyperbaric Lidocaine 5%
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitas Sebelas Maret
Osteoarthritis, Knee
Perineural Steroids for Peripheral Nerve Blocks
This study will look at the efficacy of dexamethasone for prolongation of peripheral nerve blocks.
- Trial name
- NCT02462148
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain, Trismus
2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
Dental treatments, particularly third molars extraction, can become extremely uncomfortable and painful. They are associated to anxiety, fear and many other unpleasant sensations.
- Conditions
- Pain, Trismus, Edema
- Trial name
- NCT02603198
- Testing
- mepivacaine chloridrato epinephrine, mepivacaine chloridrato levonordefrin
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
A Randomized, Double-Blind, Trial Comparing Epinephrine Versus Phenylephrine as a Vasoconstrictor in Regional Anesthesia for Upper Extremity Surgery
The study involves research, the purpose of which is to compare three different drug mixtures (Epinephrine, Phenylephrine 25 µg, or Phenylephrine 50 µg). Specifically, how long each medicine lasts will be studied.
- Trial name
- NCT00225043
- Testing
- Epinephrine/phenylephrine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Radius Fracture Distal
WALANT in Distal Radius Fracture Osteosynthesis
The purpose of this study is to assess the applicability and potential benefits of Wide Awake Local Anesthesia No Tourniquet (WALANT) or Local Anesthesia No Tourniquet ("LANT) versus locoregional anesthesia (LRA) and tourniquet…
- Trial name
- NCT05421000
- Testing
- WALANT, Locoregional anesthesia and tourniquet
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hospital Arnau de Vilanova
Peribulbar Anesthesia
Atracurium Versus Atracurium and Magnesium Sulphate As Adjuvants to Local Anesthetic
To evaluate the effects of adding magnesium sulfate to atracurium with local anesthetic mixture on akinesia of globe and eyelid regarding onset and duration in cataract surgery using peribulbar technique
- Trial name
- NCT06600945
- Testing
- Cataract surgery
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Dalia yousry Mohamed elsayed
Anxiety
Melatonin vs Pregabalin for Anxiolysis and Sedation
preoperative melatonin, pregabalin or both will be given to all patients preoperative
- Trial name
- NCT05221151
- Testing
- Melatonin, Pregabalin, Ondansetron 4 MG
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Regional Anesthesia, Anxiety
Uncontrolled Disinformation About Regional Anesthesia and Pregnant Patients.
Nowadays, hundreds of information about regional anesthesia are accessed from any internet search engine when a question is written about the methods of anesthesia that can be applied during C/S.
- Conditions
- Regional Anesthesia, Anxiety, Social Media Addiction, Spinal Anesthesia
- Trial name
- NCT05416541
- Testing
- social media
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Diabetes Mellitus, Diabetic Neuropathy
Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management
- Trial name
- ANKLE-DM (NCT07404124)
- Testing
- Ultrasound-Guided Ankle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Postoperative Complications
Impact of Local Anesthesia on Postbronchoscopy Fever: a Randomised Controlled Study
Impact of Local Anesthesia on Postbronchoscopy Fever: a Randomised Controlled Study
- Trial name
- NCT02961075
- Testing
- local surface anesthesia, Laryngeal tube
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Thyroid Diseases, Parathyroid Diseases
Ropivacaine Plus Magnesium Sulphate Infiltration
In the domain of endocrine gland surgery, thyroidectomy is the most common procedure. Patients report moderate to severe discomfort postoperatively, which is induced by a variety of mechanisms, the most common of which are…
- Conditions
- Thyroid Diseases, Parathyroid Diseases, Postoperative Pain, Anesthesia, Local
- Trial name
- NCT05294393
- Testing
- Ropivacaine 10%, Ropivacaine 10% plus magnesium sulphate 10mg/kg
- Where
- Greece
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Anesthesia, Local
A Safety Study of of AG-920 Sterile Topical Ophthalmic Solution
A Phase 3, randomized, placebo-controlled, double-masked, parallel study in healthy subjects. It is designed to evaluate the ocular safety of a single topical ocular administration of AG-920 sterile topical ophthalmic solution…
- Trial name
- NCT05501860
- Testing
- AG-920
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Local Anesthesia
Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar Nerve Block for Tooth Extraction
The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for anterior and middle superior alveolar nerve (AMSA)…
- Trial name
- NCT03225326
- Testing
- Computer controlled 4% articaine delivery by Anaeject, Conventional 4% articaine delivery by carpule syringe
- Where
- Serbia
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Belgrade
Pain
Comparison Between the Dentapen and Vibraject
A split-mouth, controlled trial aimed to assess patient-reported pain levels during local anaesthesia administration to the buccal side of the maxillary posterior teeth using Vibraject-assisted injection and the Dentapen® system…
- Trial name
- NCT06790433
- Testing
- Vibraject, Dentapen
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Anesthesia, Local
Reversing the Effects of 0.5% Bupivacaine
Clinical trials have shown phentolamine mesylate (PM), brand name OraVerse, to be effective at reducing the amount of time to reversal of local anesthesia with different dental anesthetics.
- Trial name
- NCT02995291
- Testing
- OraVerse, Saline Water (Control)
- Where
- Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Nausea, Vomiting
Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean
The purpose of this study is to compare the effectiveness of acupressure point P6 stimulation versus intravenous ondansetron plus metoclopramide versus no antiemetic prophylaxis during elective cesarean section under regional…
- Conditions
- Nausea, Vomiting, Satisfaction
- Trial name
- NCT02959840
- Testing
- Acupressure Point P6 stimulator, Metoclopramide, Ondansetron
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Injection Site Haematoma, Local Anesthetic Toxicity
U/S Guided SAPB Versus Conventional IV Analgesics in Postoperative Pain Management in MRM
The aim of this study is to compare the effect of ultra-sound guided serratus anterior plane block versus conventional IV analgesics in postoperative pain management in modified radical mastectomy (MRM)
- Trial name
- SAPB (NCT05126394)
- Testing
- ultrasound guided serratus anterior plane block
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Anesthesia, Local
Intralipid® 20% for Reversal of Local Anesthetics
In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits.
- Trial name
- NCT03968822
- Testing
- Lidocaine 2%, Lidocaine 1%, Bupivacaine 0.25%
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York