Clinical trials: Local Anesthetic Complication
Pain, Postoperative, SPINAL Fracture
Bilateral Erector Spinae Plane Block Versus Local Anesthetic Infiltration for Perioperative Analgesia in Spine Surgery.
Postoperative pain still represents an important perioperative issue, affecting more than 80% of patients undergoing surgery. A suboptimal pain management doesn't just affects quality of life, but can compromise rehabilitation…
- Conditions
- Pain, Postoperative, SPINAL Fracture, Spondylolisthesis
- Trial name
- NCT04123106
- Testing
- ESP block, Wound infiltration
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Upper Extremity Problem
Comparison of Selective Trunk and Supraclavicular Brachial Plexus Blocks
There are different methods in brachial plexus blocks for hand, wrist, forearm, and elbow operations. In this study, the anesthetic efficacy of the ultrasound-guided selective truncus methods and the supraclavicular methods for…
- Trial name
- NCT06004648
- Testing
- Upper extremity surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Local Anaesthetic Complication
Evaluation of the Satisfaction of Patients With Conization Under Local Anesthesia
In France, screening involves a routine test of papanicolaou in women aged 25 to 65 years. In the case of an abnormal Pap smear discovery, the diagnostic strategy is based in most cases in colscopy to allow cervical biopsies if…
- Trial name
- ESCAL (NCT03157752)
- Testing
- Quality of life questionnaire
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Montpellier
Post Operative Pain, Appendicitis Acute
Transversus Abdominis Plane Block Versus Quadratus Lumborum Block for Pain Management in Laparoscopic Appendectomy
Laparoscopic appendectomy causes postoperative pain. The primary objective of this prospective randomized controlled study is to compare the effect of ultrasound (US)-guided quadratus lumborum block (QLB) on 24-hour cumulative…
- Conditions
- Post Operative Pain, Appendicitis Acute, Surgery
- Trial name
- NCT05310266
- Testing
- Transversus abdominis plane block, Quadratus Lumborum Block
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Pain, Postoperative
Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery
A prospective, randomized comparison of bupivacaine to liposomal bupivacaine given by local injection at all the wound sites in patients undergoing robotic-assisted or laparoscopic urologic surgeries in an effort to determine…
- Trial name
- NCT02222129
- Testing
- Bupivacaine, liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Knight, Richard, M.D.
Fusion of Spine, Lumbar Region, Anesthesia, Local
Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery
The purpose of this study is to determine if the method for injecting local anesthesia affects patients' pain and opioid usage after surgery.
- Conditions
- Fusion of Spine, Lumbar Region, Anesthesia, Local, Pain, Postoperative, Opioid Use
- Trial name
- NCT06528288
- Testing
- Erector Spinae Plane Block, Subcutaneous Anesthesia
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Massachusetts, Worcester
Opioid Use, Postoperative Pain
Comparison of Postoperative Analgesia Methods in Elective Cesarean Section Surgeries
Since many intravenous anesthetic agents administered to the mother can cross the placental barrier and cause fetal side effects, multimodal analgesia strategies with peripheral nerve blocks are preffered with greater safety in…
- Trial name
- NCT06425718
- Testing
- Postoperative Pain Management Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Marmara University
Post Operative Pain, Appendicitis
Evaluation of Local Anesthetic at Incision Site
Patient will have usual appendectomy surgery with an injection of local or saline at incision site either before or after the incision at random.
- Trial name
- NCT02483689
- Testing
- Pre Incisional Local Anesthetic, Pre-Incisional Saline, Post-Closure Local Anesthetic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Valley Anesthesiology Consultants
Pain, Postoperative, Nausea, Postoperative
Intraoperative Autonomic Neural Blockade
The duration of the effect of autonomic neural blockade (ANB) is the most critical limitation for successful clinical application. The analgesic effect using only 0.5% bupivacaine may wear off after 12 to 18 hours.
- Conditions
- Pain, Postoperative, Nausea, Postoperative, Vomiting, Postoperative, Analgesia
- Trial name
- ANB (NCT06137924)
- Testing
- Local anesthetic injection Bupivacaine plus dexamethasone, Local anesthetic injection bupivacainde plus dexamethasone plus a colloid, Local anesthetic injection bupivacaine plus clonidine
- Volunteers
- 150 people
- Sponsor
- Universidad Simón Bolívar
Pain
Local Infiltration Analgesia After Abdominal Hysterectomy
The aim of the study is to evaluate traditional analgesic therapy after abdominal hysterectomy with single infiltration of local anesthetics in the surgical area at the end of surgery.
- Trial name
- LIA (NCT01782781)
- Testing
- ropivacaine, ketorelac and epinephrine
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Cholelithiases, Cholecystitis
Ultrasound-Guided Rectus Sheath Block Versus Local Infiltration
Laparoscopic cholecystectomy is associated with significant postoperative pain originating from trocar sites, pneumoperitoneum, and visceral irritation.
- Conditions
- Cholelithiases, Cholecystitis, Postoperative Pain
- Trial name
- NCT07582029
- Testing
- Rectus Sheath Block, Local Anesthetic Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Pain, Postoperative, Bruising
Use of Tranexamic Acid in Blepharoplasties
The goal of this investigation is to assess whether or not there is a significant difference in the presence and/or degree of post-operative ecchymosis, pain, and edema between groups of patients undergoing upper lid…
- Trial name
- NCT04724772
- Testing
- Tranexamic acid injection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Regional Anesthesia Morbidity, Arthropathy of Hip
Comparison of PENG Associated with LFCN Block Versus FICB for Multimodal Analgesic Management in THA
Optimal pain control with limited muscle weakness is paramount for a swift initiation of physical therapy and ambulation. Fascia iliaca compartment block (FIC) has been recommended since it offers the best pain control with low…
- Conditions
- Regional Anesthesia Morbidity, Arthropathy of Hip, Hip Arthropathy, Post Operative Pain
- Trial name
- NCT06147401
- Testing
- PENG plus LFCN block, FIC Block
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Ospedale Edoardo Bassini
Abdominal Hysterectomy
A Comparison Between Continuous and Intermittent Intraabdominal Analgesia Using Local Anaesthetics
The investigators hypothesis is that patient controlled local anesthetics administered intraabdominally are more efficacious compared to continuous infusion in reducing postoperative pain and morphine consumption.
- Trial name
- PoPuLAR (NCT01492075)
- Testing
- PCRA (Intermittent injection)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Örebro University, Sweden
Postoperative Pain, Spine Deformity
Intraoperative Placement of Superficial Erector Spinae Plane Block; A New Approach in Spine Surgery
Major spine surgery causes severe postoperative pain. The primary objective of this randomized controlled study is to compare the effect of ultrasound (US)-guided superficial erector spinae plane (ESP) block on 48-hour…
- Conditions
- Postoperative Pain, Spine Deformity, Spine Injury, Spine Fracture
- Trial name
- NCT05244031
- Testing
- superficial erector spina plane block, Standard (opioid-based) analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Pain, Postoperative, Chronic Postoperative Pain
Analgesia in Laparoscopic Cholecystectomy
The investigators hypothesis is that perioperative infusion of 0.75 ropivacaine in patients undergoing laparoscopic cholecystectomy may modify the intensity of postoperative pain or the analgesic consumption during the first 24…
- Trial name
- NCT01388946
- Testing
- Ropivacaine 0.75, Normal saline
- Where
- 2 sites in Greece
- Volunteers
- 110 people
- Sponsor
- University of Athens
Pain, Acute Postoperative, Trauma Injury
Patient-Titrated Automated Intermittent Boluses of Local Anesthetic vs. a Continuous Infusion Via a Perineural Catheter for Postoperative Analgesia
This will be a randomized comparison of continuous local anesthetic infusion with patient controlled boluses (PCA) to patient-titratable automated boluses with patient controlled boluses (PCA) for both infraclavicular and…
- Trial name
- NCT05091905
- Testing
- Continuous Infusion of ropivacaine 0.2%, Titratable Automated Intermittent Boluses of ropivacaine 0.2%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Postoperative Pain, Acute Pain
Two Bupivacaine Concentrations for Rectus Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy
Pain after laparoscopic cholecystectomy remains clinically relevant, and current recommendations favour multimodal, opioid-sparing analgesia including regional techniques.
- Conditions
- Postoperative Pain, Acute Pain, Cholelithiasis, Anesthesia
- Trial name
- NCT07841951
- Testing
- Bupivacaine 0.25% - rectus intercostal fascial plane block, Bupivacaine 0.125% - rectus intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Medipol University
Nephrolithotomy, Percutaneous, Anesthetics, Local
Efficiency of Erector Spinae Plane Block For Patients Undergoing Percutaneous Nephrolithotomy
Investigators' goal is to determine whether Erector Spinae Plane Block would provide a better analgesia, help mobilization and early discharge or increase satisfaction for patients undergoing Percutaneous Nephrolithotomy(PNL).
- Conditions
- Nephrolithotomy, Percutaneous, Anesthetics, Local, Nerve Block, Erector Spinae Plane Block
- Trial name
- NCT03652103
- Testing
- Ultrasound Guided Erector Spinae Plane Block Catheterisation, Bupivacaine 0.25% Injectable Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bozyaka Training and Research Hospital
Analgesia
Pediatric Postoperative Analgesia Herniorrhaphy Study
This is a Phase 2 study in pediatric subjects undergoing inguinal herniorrhaphy.
- Trial name
- NCT03922048
- Testing
- HTX-011, Bupivacaine HCl, Luer Lock Applicator
- Sponsor
- Heron Therapeutics