Clinical trials: Local Disease
Flat Feet, Lower-Limb Muscle Activation
Plantar Stimulation, Whole-Body Vibration, and Baduanjin for Muscle Activation
This study will examine how different short-term exercise and vibration conditions affect lower-limb muscle activity in young adults with flat feet and young adults with normal feet.
- Conditions
- Flat Feet, Lower-Limb Muscle Activation, Neuromuscular Response
- Trial name
- NCT07811674
- Testing
- Whole-body Vibration Training,Whole-Body Vibration With Regional Plantar Stimulation,Baduanjin
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Spinal Tuberculosis, Mesenchymal Stem Cell
Effectivity of Mesenchymal Stem Cell on Vertebral Bone Defect Due to Mycobaterium Tuberculosis Infection
This study evaluates the effectiveness of locally implantation of mesenchymal stem cell on vertebral bone defects due to infection of mycobacterium tuberculosis.
- Trial name
- NCT04493918
- Testing
- Mesenchymal Stem cell + Nacl 0.9%, NaCl 0.9%
- Where
- Indonesia
- Volunteers
- 20 people
- Sponsor
- Ahmad Jabir Rahyussalim
Peripheral Arterial Disease
Exercise Test and Sequential Training Strategies in PAD
Diabetic lower extremity disease, including peripheral vascular disease, peripheral neuropathy, foot ulcers, or leg amputation. Among them, peripheral arterial disease (PAD) is an important expression of systemic atherosclerosis.
- Trial name
- NCT03965520
- Testing
- exercise rehabilitation by near-infrared spectrometer
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Pain, Postoperative, Bariatric Surgery Candidate
A Study to Compare Two Techniques for Pain Control After Bariatric Surgery
The purpose of this study is to compare the postoperative pain and other clinical outcomes in patients who, during bariatric surgery, will be injected with a local anesthetic (Ropivacaine) through two different techniques.
- Trial name
- NCT04427059
- Testing
- Transversus Abdominis Plane (TAP) block, Port-Site Infiltration (PSI)
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- Fabio Garofalo
Pain
US Guided Sacroiliac Joint Injection
Sacroiliac joint (SIJ) pain is one of the underappreciated causes of low back pain. Recent studies have reported excellent outcomes after Ultrasound (US) guided SIJ injection with local anesthetics and corticosteroids, but these…
- Trial name
- NCT06684938
- Testing
- sacroiliac injection
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Liposarcoma of Soft Tissue, Surgical Procedure, Unspecified
Status of Surgical Resection and Histologic Subtype as Predictors of Local Recurrence in Retroperitoneal Liposarcoma
Soft tissue sarcomas are rare malignant tumors. Liposarcoma constitute the most frequent histological subtype of retroperitoneal sarcoma. The prognosis of soft tissue sarcomas depend on clinical and histologic characteristics.
- Trial name
- NCT05428579
- Testing
- Retroperitoneal Liposarcoma resection
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Complex Regional Pain Syndromes
Impact of Compression Garments on Pain in Patients With Complex Regional Pain Syndrome of the Upper Limbs.
The aim is to study another alternative for the treatment of pain in people with CRPS. Indeed, the TRAB / Medullary occupational therapy department of the CMRRF in Kerpape used compression garments to reduce edema when it was…
- Trial name
- VECODON (NCT05034835)
- Testing
- usual treatment with compression garments (CERECARE), usual treatment without compression garments (CERECARE)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape
Acute Renal Failure, Dialysis Related Complication
Simplified Regional Citrate Anticoagulation Protocols for CVVH, CVVHDF and SLED: a Pilot Study
The aim of the study are: 1) To evaluate the occurrence of acid-base alterations and the incidence of hypophosphatemia during different modalities of Renal Replacement Terapy (RRT) in critically ill patients [CVVH, CVVHDF and…
- Conditions
- Acute Renal Failure, Dialysis Related Complication, Hypophosphatemia, Hypomagnesemia
- Trial name
- NCT03976440
- Testing
- Renal Replacement Therapy (RRT) start
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Parma
Effects of; Anesthesia, Spinal and Epidural, in Pregnancy
Influence of Maternal Postioning on Spread of Local Anesthetic After Epidural Analgesia
The purpose of this study is to determine if a lateral positioning of the pregnant woman after epidural analgesia increases the incidence of unilateral functioning epidurals.
- Trial name
- NCT02617823
- Testing
- lateral position
- Where
- 2 sites in Sweden
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Region Skane
Lignocaine, Anesthesia, Local
Comparison of Pre-procedure Lignocaine Spray Versus Spray-as-you-go for Topical Airway Anesthesia in Flexible Bronchoscopy
Title: Comparing Two Methods of Topical Anesthesia for Fiberoptic Bronchoscopy Purpose: To compare the effectiveness of two methods of anesthesia, pre-procedure lignocaine spray (PPL) and spray-as-you-go (SAYG), in reducing…
- Conditions
- Lignocaine, Anesthesia, Local, Trachea, Airway Disease
- Trial name
- NCT07084623
- Testing
- Pre-procedure lignocaine spray (PPL), Lignocaine Spray (Spray-as-you-go)
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Melanoma
Review of the Literature and Serie of Patients Who Underwent Reconstruction After Wide Local Excision of Nail Apparatus for Melanoma
Melanomas of the nail bed are often diagnosed at the locally advanced stage. The standard treatment was amputation of the finger or toe, but it has now been established that enlarged excision of the nail plate is sufficient under…
- Trial name
- NCT06861023
- Testing
- Patients who have undergone extensive nail resection with reconstruction
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Scalp Nerve Block, Craniotomy Surgery
The Efficacy of Regional Scalp Block in Craniotomy
The objective of this clinical trial is to evaluate the role of scalp nerve block in craniotomy. The primary questions it seeks to answer are: What are the efficacy and safety profiles of scalp nerve block in craniotomy? The…
- Trial name
- NCT06720285
- Testing
- nerve block with 0.5% ropivacaine, General anesthesia and opioids (fentanyl, propofol, rocuronium)
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Airlangga
Cervical Cancer, Endometrial Cancer
CerviPrep for Applying Topical Gemcitabine to the Cervix in Treating Patients With Primary Endometrial, Cervical, or Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT00610740
- Testing
- topical gemcitabine hydrochloride, therapeutic conventional surgery
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Neuropathic Pain, Complex Regional Pain Syndrome Type 1
Effectiveness of Ketamine Administered by Mesotherapy in Complex Regional Pain Syndrome Type 1 (CRPS1)
Complex Regional Pain Syndrome type 1 (CRPS1) is a disabling pain syndrome. Its definitive treatment has not been established and the results of current treatments are often unsatisfactory.
- Trial name
- MESO-SDRC (NCT04650074)
- Testing
- LIDOCAINE 20 mg, LIDOCAINE 20 mg + KETAMINE 20 mg, LIDOCAINE 20 mg + KETAMINE 40 mg
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
Hemodialysis, Thromboinflammation
Effect of Modifying Magnesium Concentration in Citrate-enriched Dialysate on Hemodialysis-associated Thromboinflammation
This clinical trial investigates whether the composition of dialysate influences hemodialysis-associated thromboinflammation. Specifically, it evaluates the effects of magnesium concentration and acid type in dialysate on immune…
- Conditions
- Hemodialysis, Thromboinflammation, Hemodialysis Complication, End Stage Renal Disease (ESRD)
- Trial name
- pilot OMAGOD + (NCT07206524)
- Testing
- Hemodialysis using dialysate containing citric acid and magnesium at a concentration of 1.0 mmol/L, Hemodialysis using acetic acid dialysate with magnesium 0.5 mmol/L, Hemodialysis using citric acid dialysate with magnesium 0.75 mmol/L
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Universitair Ziekenhuis Brussel
Radiation-Induced Intestinal Injury
Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury
Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant.
- Trial name
- NCT06410443
- Testing
- Dexamethasone, Antibiotics, probiotics, vitamins, antidiarrheal drugs, enteral nutrition, and endoscopic argon plasma coagulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Shenyang Military Region
Postanesthetic Excitement, Cesarean Section
Dexmedetomidine Compared to Ondansetron for Postanaesthetic Shivering in Patients Undergoing a Cesarean Section
Evaluate the efficiency of management with intravenous dexmedetomidine compared to intravenous ondansetron to achieve the disappearance of post-anesthetic shivering in a shorter time in the obstetric patient undergoing cesarean…
- Trial name
- NCT06289335
- Testing
- saline solution
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital Central "Dr. Ignacio Morones Prieto"
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Advanced or Metastatic NSCLC
A Study to Investigate Efficacy and Safety of Ceralasertib Plus Durvalumab in Participants Aged ≥ 18 Years With Advanced or Metastatic Non-small Cell Lung Cancer Whose Disease Progressed on or After Prior Anti-PD-(L)1 Therapy and Platinum-based Chemotherapy
A study to investigate efficacy and safety of ceralasertib plus durvalumab in participants aged ≥ 18 years with advanced or metastatic non-small cell lung cancer whose disease progressed on or after prior anti-PD-(L)1 therapy and…
- Trial name
- LOTOS (NCT05941897)
- Testing
- Ceralasertib, Durvalumab
- Where
- 8 sites in Russia
- Volunteers
- 39 people
- Sponsor
- AstraZeneca
Healthy
Post-Market Clinical Follow-up HVS on Increased Circulation, RPW2 and Cefar TENS
The study is a prospective, single-center, open-label, post-market investigational study on healthy volunteers conducted in the United Kingdom.
- Trial name
- NCT06590610
- Testing
- Radial pressure wave (RPW) - Intelect RPW2 Chattanooga
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DJO UK Ltd
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