Clinical trials: Local Disease
Knee Osteoarthritis, Anesthesia, Local
Liposomal Bupivacaine in Total Knee Arthroplasty
Pain management after total knee arthroplasty is essential for optimized clinical outcomes and higher satisfaction. Exparel (Pacira Pharmaceuticals, Parsippany, New Jersey, USA) is a long-acting Bupivacaine extended release…
- Trial name
- NCT03541265
- Testing
- Exparel, Adductor block protocol, peri-articular injection protocol
- Volunteers
- 70 people
- Sponsor
- Bronx-Lebanon Hospital Center Health Care System
Genetic Polymorphism, Macular Degeneration
Does Complement Factor H Gene Polymorphism Play a Role in the Regulation of Vascular Tone in the Choroid?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Conditions
- Genetic Polymorphism, Macular Degeneration, Regional Blood Flow, Ocular Physiology
- Trial name
- NCT00708929
- Testing
- Squatting
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Colo-rectal Cancer
Study on the Prediction of Regional Lymph Node Metastasis in Colorectal Cancer by Spectral CT Combined With MSI
Spectral CT was used to prospectively collect medical images and clinical data related to colorectal cancer, evaluate the effect of image quality in the diagnosis of colorectal cancer, and evaluate the application value in the…
- Trial name
- NCT07565831
- Testing
- Investigating the role of spectral CT combined with MSI status in the diagnosis and treatment of colorectal cancer lymph nodes.
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Yunnan Cancer Hospital
Acute Kidney Injury
Oxidative Stress and Circulating Nuclear DNA (cfDNA) in Acute Kidney Injury and Continuous Renal Replacement Therapies.
Acute kidney injury (AKI) is the inability of the kidneys to perform their functions of purifying and cleaning the blood. It is a frequent complication in hospitalized patients, especially in those admitted to the ICUs.
- Trial name
- NCT06646328
- Testing
- Central venous access, Pump-assisted circuit, Heparin sodium
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fernando Sanchez
Comparison of Onset Time
Onset Time of Brachial Plexus Block Using Local Anaesthetic Diluted With 0.9% Saline vs 5% Dextrose
Regional anesthesia employs the use of local anesthetics (LA) to block specific nerves to enable pain free surgery to be performed, or for intra and post operative pain relief.
- Trial name
- NCT01815944
- Testing
- 0.75% Ropivacaine, Normal saline, Dextrose 5%
- Where
- Malaysia
- Volunteers
- 55 people
- Sponsor
- University of Malaya
Bariatric Surgery Candidate
The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery
This is a pilot study in a randomized, controlled, double-blinded format and will evaluate the ability of a local anesthetic, Ropivacaine, to decrease pain after gastric bypass surgery.
- Trial name
- INOPAIN (NCT02154763)
- Testing
- Ropivacaine, Normal Saline
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Inflammation, Burns
Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing
The purpose of this study is to evaluate the change in signs of inflammation/local infection when Mepilex Border Ag is used in normal clinical practice when used on chronic ulcers (venous leg, diabetic foot and pressure ulcers)…
- Conditions
- Inflammation, Burns, Ulcers
- Trial name
- NCT01214811
- Testing
- Mepilex Border Ag
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Molnlycke Health Care AB
Early-stage Breast Cancer, Estrogen-receptor-positive Breast Cancer
Ketorolac and Pregabalin Effects on breaSt Cancer (KePreSt)
Out of all proportion to its short duration, the perioperative period is critical in determining the long-term outcome of cancer.
- Trial name
- KePreSt (NCT06150898)
- Testing
- Prospective data and sample collection, Ketorolac 10 Mg Oral Tablet, Pregabalin 75mg
- Where
- Belgium
- Volunteers
- 112 people
- Sponsor
- Jules Bordet Institute
Knee Arthropathy, Postoperative Pain
Optimization of a Fast-track Concept for Knee Joint Replacement
In an estimated 150,000 patients, a knee joint replacement is performed in Germany every year. The perioperative care of the patients aims at an optimal surgical technique, which leads to a high functionality in the joint, and…
- Conditions
- Knee Arthropathy, Postoperative Pain, Postoperative Complications
- Trial name
- KneeOptOut2 (NCT03920930)
- Testing
- Late local infiltration analgesia, Early local infiltration analgesia
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Charite University, Berlin, Germany
Postoperative Pain, Hip Osteoarthritis
Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blocks for Hip Surgery Analgesia
This study aims to investigate the efficacy of adding a Posterior Pericapsular Deep gluteal block to two other standard nerve blocks-the Pericapsular Nerve Group block and the Lateral Femoral Cutaneous Nerve block-for patients…
- Conditions
- Postoperative Pain, Hip Osteoarthritis, Hip Fractures
- Trial name
- NCT07531030
- Testing
- Posterior Pericapsular Deep Gluteal, Pericapsular Nerve Group, and Lateral Femoral Cutaneous Nerve Blocks., Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blocks.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Muscle Fatigue, Exertion, Perceived
The Influence of Passive Local Muscle Vibration on Mechanical Power Output and Neuromuscular Activity During Counterbalanced RPE-clamped Cycling: A Randomized Controlled Trial
The purpose of this study is to find out if applying mild mechanical vibration (100 Hz) to the the Achilles and patellar tendons before and during exercise can make cycling feel easier and help athletes generate more power.
- Conditions
- Muscle Fatigue, Exertion, Perceived, Neuromuscular Activity, Athletic Performance
- Trial name
- NCT07715292
- Testing
- Tendo device Vibrration, Laboratory control vibration
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wrocław University of Science and Technology
Effect of RBC Transfusions on Cerebral Oxygen Saturation
Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients
Critically ill patients are frequently transfused with red blood cell (RBC) units with the predominant intention to increase arterial oxygen content and thus oxygen delivery to the tissues.
- Trial name
- NCT02232412
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Complex Regional Pain Syndromes
Benefit of Augmented Reality Mirror Therapy in Addition to Conventional Management in Complex Regional Pain Syndrome of the Upper Extremity
Complex Regional Pain Syndrome (CRPS) is a "polymorphic joint and periarticular pain syndrome associated with various changes in sensitivity, vasomotor, sudomotor, muscular and trophic changes".
- Trial name
- REFLEXION (NCT05787119)
- Testing
- Conventional therapy, ARMT, cortical reactivity
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Anesthesia, Local
Efficacy of Transversus Abdominis Plane Block
This study aims to assess the efficacy of Transversus Abdominus Plane (TAP) blocks, a well-established anesthetic technique, to decrease the amount of post-operative pain in patients who undergo minimally invasive gynecologic…
- Trial name
- NCT06274307
- Testing
- Transversus abdominis plane block
- Where
- 2 sites in United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Justin Hruska
Ppancreatic Cancer
Study on Efficacy and Safety of VMAT Technique With Local Dose Escalation for Unresectable Pancreatic Cancer
The goal of this observational study is to learn about the efficacy and safety of the Volumetric Modulated Arc Therapy (VMAT) dose sculpting technique combined with different radiotherapy doses (local dose escalation vs.
- Trial name
- NCT07242911
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chifeng Tumor Hospital
Blood Pressure Monitoring, Ambulatory, Cardiovascular (CV) Risk
Work-Related Frustration and Higher Cardiovascular Risk Blood Pressure Profiles
Background: Mental health is a national priority in France, especially in the workplace. The impact of poor quality of life at work on mental health has been demonstrated.
- Conditions
- Blood Pressure Monitoring, Ambulatory, Cardiovascular (CV) Risk, Quality of Life at Work, Hypertension
- Trial name
- TRACA (NCT07740434)
- Where
- 3 sites in France
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- University of Burgundy
Breast Cancer
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy.
- Trial name
- TAILOR RT (NCT03488693)
- Testing
- Radiation, No Radiation
- Where
- 485 sites in United States, Canada
- Volunteers
- 2,138 people
- Sponsor
- Canadian Cancer Trials Group
Myxoid Liposarcoma
International Prospective Registry on Local Treatment Approaches in MLS
To prospectively study commonly used local treatment approaches in Myxoid Liposarcoma (MLS)
- Trial name
- NCT04699292
- Testing
- Surgery, Preoperative RT 36Gy, Preoperative RT 50Gy
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- The Netherlands Cancer Institute
Epidural Related Maternal Fever, Analgesia, Epidural
The Impact of Local Anesthetic Solution Temperature on Epidural-related Maternal Fever
This study investigates how the temperature of local anesthetics affects maternal fever related to epidural analgesia during childbirth.
- Conditions
- Epidural Related Maternal Fever, Analgesia, Epidural, Fever, Intrapartum Fever
- Trial name
- NCT06682416
- Testing
- In the context of epidural analgesia, the temperature of the local anesthetic solution is elevated to 37°C utilizing a blood transfusion and infusion warmer.
- Where
- 2 sites in China
- Volunteers
- 424 people
- Sponsor
- The First Affiliated Hospital of Soochow University
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