Clinical trials: Local Disease
Anxiety
Assessment of the Aromatherapy to Alleviate Peri Operative Anxiety in Ambulatory Elective Upper Limb Surgery Under Loco-regional Anesthesia
AROMA study is a randomised controlled parallel-group single-site study. Patients randomized in the experimental group benefit from the aromatherapy at their arrival in the operating theatre in the recovery room.
- Trial name
- AROMA (NCT03583801)
- Testing
- Olfactory aromatherapy, without aromatherapy
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Lille
Hip Osteoarthritis, Total Hip Arthroplasty (THA)
QIPB vs SI-FICB for Postoperative Analgesia After Total Hip Arthroplasty
Total hip arthroplasty (THA) causes moderate-to-severe postoperative pain. The PROSPECT guideline recommends the supra-inguinal fascia iliaca compartment block (SI-FICB) for THA, whereas evidence for newer…
- Conditions
- Hip Osteoarthritis, Total Hip Arthroplasty (THA), Postoperative Pain, Acute Pain
- Trial name
- NCT07683663
- Testing
- Supra-Inguinal Fascia Iliaca Compartment Block, Quadro-Iliac Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Dokuz Eylul University
Alzheimer's Disease
Early Counseling and Support for Alzheimer's Disease Caregivers
This randomized trial evaluates the efficacy of counselling for reducing anxiety and depression in caregivers of patients with dementia.
- Trial name
- D_CareGiver (NCT02685787)
- Testing
- Psychosocial Intervention, Educational Intervention on AD
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- Azienda Sanitaria Locale N.1 dell'Umbria
Thyroid Cancer
Anlotinib or Penpulimab in Combination With RAI for DTC
The purpose of this study is to assess the efficacy and safety of anlotinib in combination with I-131 in locally advanced/metastatic differentiated thyroid cancer.
- Trial name
- NCT04952493
- Testing
- Anlotinib hydrochloride, Sodium Iodide I 131, Penpulimab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking Union Medical College Hospital
Physical Inactivity
The Role of Intermediaries in Connecting Individuals to Local Physical Activity - Study Protocol
Intermediaries help people to connect to community-based services and supports, including physical activity and exercise groups (physical activities). They do this by acting as a link person.
- Trial name
- NCT06260995
- Testing
- Social Prescribing Link Worker Intermediary Intervention, Local Sports Partnership Community Development Officer Intervention
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Abdominal Pain
Continuous Local Anesthetic and Steroid Infusion in Abdominal Surgery
The aim of the study is the identification, comparing continuous infusion of local anesthetics and steroids intralesionally with the current gold standard therapy (PCA), of the effective dose of local anesthetics and steroids…
- Trial name
- GR-CWI (NCT02002663)
- Testing
- ropivacaine 0.2%, Methylprednisolone 1mg/kg, saline 0.9%
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Aortic Diseases, Aortic Aneurysm
LANDMARC Study: a Study With Focus on Aorta Ascendens
Rationale: Aortic diameter is currently used as a gold standard in international guidelines for prediction of aorta pathology (aortic aneurysm and aortic dissection).
- Conditions
- Aortic Diseases, Aortic Aneurysm, Aortic Dissection, Aortic Aneurysm, Thoracic
- Trial name
- NCT05655767
- Testing
- 4D-flow MR & CT-scan
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Maastricht University Medical Center
Healthy
An Open Label Study to Evaluate the Impact of Duration of Subcutaneous Infusion of a Novel, pH Neutral Formulation of Furosemide (Furoscix®) on Safety and Local Skin Tolerability
This is a Phase 1 study to evaluate the safety and tolerability of shortened subcutaneous infusions of Furoscix.
- Trial name
- NCT04161482
- Testing
- Furosemide 80 mg (8 mg/mL)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- scPharmaceuticals, Inc.
Orthopedic Disorder
Patient-controlled Sedation With Propofol Versus Anesthesiologist-administered Sedation for Orthopedic Surgery
The purpose of this study is to compare patient satisfaction with patient-controlled sedation with propofol and anesthesiologist-controlled sedation during orthopedic procedures of the upper limb under locoregional anesthesia.
- Trial name
- PACOSA (NCT06451380)
- Testing
- orthopaedic surgery, propofol anesthesia
- Where
- France
- Volunteers
- 70 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Digital Ulcers in Systemic Sclerosis
Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis
The main goal of this clinical trial is to learn about how safe the new drug TOP-N53 solution is when it is applied to open wounds on the fingertip (digital ulcers) in people with an uncommon illness that results in hard…
- Trial name
- TOP-N53-02 (NCT06954597)
- Testing
- TOP-N53, Sildenafil, TOP-N53 vehicle
- Where
- 6 sites in France, Switzerland
- Volunteers
- 15 people
- Sponsor
- Topadur Pharma AG
Knee Osteoarthritis
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee…
- Trial name
- NCT02863120
- Testing
- liposomal bupivacaine, bupivacaine HCl, Ropivacaine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Texas Orthopaedics, Sports and Rehabilitation Associates
Block, Block, Fascicular
Pain Relief and and Peripheral Perfusion Index During Erector Spinae Block
The primary endpoint of this study is to compare the pain relief and peripheral perfusion index when local anesthetics injected in different final target area during lumbar erector spinae block The secondary endpoint of this…
- Conditions
- Block, Block, Fascicular, Spinae
- Trial name
- NCT06963424
- Testing
- Erector Spinae Plane Block
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Keimyung University Dongsan Medical Center
Pain, Cesarean Delivery
Local Lidocaine Infiltration for Pain Management Post Cesarean Delivery.
The objective of this prospective, double-blinded, placebo-controlled, randomized study is to evaluate the impact of preemptive analgesia using incisional site infiltration of lidocaine as compared to saline solution on post…
- Trial name
- NCT00737542
- Testing
- lidocaine, NACL 0.9%
- Where
- Israel
- Sponsor
- Soroka University Medical Center
Urinary Stress Incontinence
Safety and Efficacy Study on the Implantation of the Tension-Free Vaginal Tape (TVT-Secur) Under Local Anesthesia
The objective was to observe the satisfaction of local anesthesia during the implantation of the TVT-SECUR for the treatment of stress urinary incontinence, with the use of questionnaires completed by the patients, and to…
- Trial name
- NCT00904618
- Testing
- TVT-SECUR - 'Hammock' technique, TVT-SECUR - 'U-Method', Local anesthesia (30 to 40 ml of a mixture of 35 ml of lidocaine 2% and 5 ml of bicarbonate 3%).
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Université de Sherbrooke
Breast Cancer
Therapeutic Nipple Sparing Mastectomy.
This is a phase III, multicentric, single arm study with a sequential design using the exact conditional Poisson test. The primary objective of this prospective study is to evaluate whether selected breast carcinoma patients…
- Trial name
- MAPAM-01 (NCT02311959)
- Testing
- Nipple sparing mastectomy
- Where
- 33 sites in France
- Volunteers
- 450 people
- Sponsor
- Institut Claudius Regaud
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Pain, Acute, Postoperative Pain
Quadratus Lumborum Block vs Erector Spinal Block for Post Abdomen Surgery Analgesia
Prior to surgery, patients will be stratified into groups according to the type of surgical procedure. The anticipated groups are as follows: Patients with colorectal cancer Patients with prostate cancer Patients with renal…
- Conditions
- Pain, Acute, Postoperative Pain, Anesthetics, Local
- Trial name
- NCT05446727
- Testing
- Ropivacaine injection
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Jagiellonian University
COPD
Singing for Wellness: Is Singing a Useful Way of Supporting People in South Devon to Self-manage Aspects of Their COPD
The aim of this study is to explore whether singing is a useful way of supporting people in South Devon to self manage aspects of their COPD and associated social isolation.
- Trial name
- NCT04360642
- Testing
- singing
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Torbay and South Devon NHS Foundation Trust
Sensation Diminished, Pinprick
A Device to Determine Return of Sensation From Spinal Block
Participation in this study will involve having a pad wrapped onto the subject's non-surgical leg to detect when sensation returns after spinal anesthetic and while in recovery room.
- Trial name
- NCT04553913
- Testing
- cooling device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences
Localized Skin Lesion, Mycosis Fungoides
Ultra Low Dose Radiation Therapy in Treating Patients With Mycosis Fungoides
This phase II trial studies how well ultra low dose radiation therapy works in treating patients with mycosis fungoides. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.
- Trial name
- NCT03398161
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Radiation Therapy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- M.D. Anderson Cancer Center
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