Clinical trials: Local Disease
Post Operative Urinary Retention
Effects of Thoracic Epidural Administered Ropivacaine Versus Bupivacaine on Bladder Function
Acute urinary retention is one of the most common complications after surgery and anesthesia. Micturition depends on coordinated actions between the detrusor muscle and the external urethral sphincter.
- Trial name
- NCT02414373
- Testing
- Ropivacaine 2mg/ml, Bupivacaine, 6 French transurethral dual channel catheter (Gaeltec, Dunvegan, Scotland)
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hepatocellular Carcinoma
Radiofrequency Ablation Combined With Recombinant Human Adenovirus Type 5 in the Treatment of Hepatocellular Carcinoma.
The primary reason for recurrence of hepatocellular carcinoma after radiofrequency ablation (RFA) is the micro-metastatic lesion that has not been ablated and inactivated in the transitional area.Some clinical trials have…
- Trial name
- NCT03790059
- Testing
- H101, RFA
- Where
- 2 sites in China
- Volunteers
- 160 people
- Sponsor
- Southwest Hospital, China
Chronic Low Back Pain
Epidural Study of Patients With Chronic Lower Back Pain
The purpose of this study is to examine 4 different epidural dosing regimes of local anaesthetic solution in a series of 3 epidural injections over a period of 12 months to determine the optimum dose of anaesthetic solution for…
- Trial name
- NCT00887003
- Testing
- Bupivacaine, Depo-Medrol
- Where
- Canada
- Volunteers
- 252 people
- Sponsor
- McMaster University
Hepato Cellular Carcinoma (HCC), Hand Foot Skin Syndrome
SHIELD: Sorafenib Hand-foot Syndrome Inhibition With Pre-Emptive Local Delivery of Topical Indomethacin
SHIELD is a single-center, open-label, single-arm prospective study designed to evaluate whether pre-emptive topical indomethacin can reduce sorafenib-associated hand-foot syndrome (HFS) in patients with advanced hepatocellular…
- Trial name
- NCT07560566
- Testing
- Topical Indomethacin
- Where
- Taiwan
- Volunteers
- 39 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer
STARS Breast Trial (Study of Anastrozole and Radiotherapy Sequencing Pilot)
This is a randomized study comparing the use of Anastrozole before and continuing during radiotherapy for breast cancer compared to the use of anastrozole after irradiation.
- Trial name
- NCT00126360
- Testing
- Timing of Anastrozole in respect to radiotherapy
- Where
- 4 sites in Australia
- Volunteers
- 100 people
- Sponsor
- St George Hospital, Australia
Abdominal Aortic Aneurysm, Acute Kidney Injury
Dexmedetomidine vs Propofol Sedation in Endovascular Aortic Repair
Endovascular aortic repair (EVAR) is increasingly performed under local anesthesia with intravenous sedation, but the optimal sedative agent has not been established.
- Trial name
- NCT07857005
- Testing
- Dexmedetomidine, propofol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 282 people
- Sponsor
- Bursa City Hospital
Common Cold
Local Nasal Tolerability and Safety Study of 1146A in Healthy Adult Participants
This will be a single-center, randomized, parallel-group, placebo-controlled study to assess the local nasal tolerability and safety of multiple administrations of topically (intranasally) administered 1146A delivered by a nasal…
- Trial name
- NCT02832362
- Testing
- Carbomer 980
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Endometriosis; Peritoneum, Postoperative Pain
LTAP Block in Endometriosis Surgery - a Randomised Controlled Double-blind Trial
The purpose of this study is to compare the efficacy and safety of laparoscopically inserted transversus abdominis plane block (LTAP) in comparison to local wound analgesia in laparoscopic surgery due to suspected or diagnosed…
- Trial name
- NCT04735770
- Testing
- Postoperative pain management: LTAP block or local wound anesthesia with levobupivacaine
- Where
- Finland
- Volunteers
- 46 people
- Sponsor
- Oulu University Hospital
Behavior, Child, Anxiety, Dental
Virtual Reality in Pediatric Dentistry
Dental Fear and Anxiety is an emotional experiences affecting many children and adolescents which can lead to behavioral problems in the dental setting.
- Trial name
- NCT05585905
- Testing
- Virtual Reality, Basic Behavior Guidance Techniques
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Sucessful Block With Less Hemidiaphragmatic Paresis in Distal Upper Arm Fracture
Ultrasound Guided Supraclavicular Brachial Plexus Block, Volume Comparison of Local Anaesthetics and Diaphragmatic Motility.
Brachial plexus block as done by landmark technique use large volume of local anaesthetics (at least 30-40 ml), leading to higher incidence of phrenic nerve involvement and diaphragmatic dysfunction.
- Trial name
- NCT03476694
- Testing
- ultra sound guided supraclavicular brachial plexus block
- Where
- Nepal
- Volunteers
- 60 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Postural Tachycardia Syndrome
Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome
This single-center study aims to evaluate both immediate and long-term outcomes of stellate ganglion block (SGB) in a cohort of rigorously phenotyped patients with Postural Tachycardia Syndrome (POTS).
- Trial name
- NCT06953661
- Testing
- Stellate ganglion block, Ropivacaine, Normal saline
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
This Study Aims to Evaluate the Effectiveness of the INJEX Device in Administering Local Anesthesia
Effectiveness of Needle-Free Infiltration Anesthesia in Reduction of Dental Pain and Anxiety During Local Anesthesia.
Local anesthesia is a common and essential procedure for the majority of dental treatments. The most frequently used method of administration is needle injection.
- Trial name
- NCT07426523
- Testing
- INJEX 30, Traditional syringe
- Where
- Syria
- Volunteers
- 52 people
- Sponsor
- Damascus University
COVID 19
Use of the Nasal Cannula During COVID-19
The objective of this investigation is to determine the incidence of the use of the low flow nasal cannula in suspected or confirmed cases with Covid-19
- Trial name
- NCT04376580
- Where
- Argentina
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tiva Group
Mitral Regurgitation, Local Anaesthesia
Deep Sedation Instead of General Anaesthesia in Percutaneous Mitral Valve Repair Using the MitraClip® System
Percutaneous mitral valve repair (PMVR) with the MitraClip® system has emerged as a therapeutic alternative to surgical valve repair in patients who are at high risk and unsuitable for surgery.
- Conditions
- Mitral Regurgitation, Local Anaesthesia, Percutaneous Repair
- Trial name
- NCT02023762
- Volunteers
- 21 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
CRPS (Complex Regional Pain Syndrome) Type I
Evaluation of the Relationship Between the Duration of the Evolution of the Complex Regional Pain Syndrome Type 1 (CRPS 1) and Effectiveness of the Continuous Peripheral Nerve Block (CPNB) Associated With an Intensive Rehabilitation Program
The study evaluates the relationship between the duration of evolution of SDRC1 and the efficacy of continuous peripheral nerve block (c-PNB) associated with an intensive rehabilitation program to improve the therapeutic strategy…
- Trial name
- BLOCALGO (NCT04767646)
- Testing
- Intensive rehabilitation program with CPNB
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Pôle Saint Hélier
Injection Pain, Local Anesthesia Infiltration
Clinical Trial Comparing Pain Perception in Children Using Two Different Local Anesthesia Tools
The goal of this clinical study is to learn whether the Super Pen (SP) device can reduce pain during local anesthesia (LA) infiltration for primary teeth compared to the conventional syringe (CS) in children aged 6-12 years.
- Conditions
- Injection Pain, Local Anesthesia Infiltration, Pediatric Patient
- Trial name
- NCT07292194
- Testing
- super pen
- Where
- Jordan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Lamis D. Rajab
SARS CoV 2 Infection
Nosocomial COVID-19 Infections in Patients Hospitalized at the Metz-Thionville Regional Hospital in 2021
The rate of nosocomial SARS-CoV2 infections found in the different studies since the beginning of the pandemic is very variable (<1% in hospitals in the USA to about 20% in a British hospital).
- Trial name
- COVIDIN (NCT05567874)
- Testing
- Nosocomial SARS-COV 2 Infection proportion
- Where
- France
- Volunteers
- 216 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Cystic Fibrosis
19F MRI to Evaluate Regional Ventilation in Healthy Subjects and Subjects With Cystic Fibrosis
An open label non-randomized study enrolling up to 20 healthy participants and up to 30 participants with cystic fibrosis to establish a healthy versus disease comparison.
- Trial name
- NCT03489590
- Testing
- PFP
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Breast Neoplasms
PICTURE Breast L: Patient Information Combined for Local Therapy oUtcome Assessment in bREast Cancer - Longitudinal
This project which is fully funded by the European Union FP7 Program is designed to pull together all the information we obtain from scans and x-rays to design a personalised 3-D digital model of each patient, their anatomy and…
- Trial name
- PICTURE L (NCT02341820)
- Where
- 3 sites in Netherlands, Portugal and 1 more
- Volunteers
- 83 people
- Sponsor
- University College, London
Periodontal Diseases, Local Anesthesia
The Anesthetic Effect of Anterior Middle Superior Alveolar Technique
Anesthesia of the soft and hard tissues in the maxilla may require up to five injections. Thus, the aim of the present study was to evaluate the anesthetic efficacy in buccal tissues after the use of the anterior middle superior…
- Conditions
- Periodontal Diseases, Local Anesthesia, Pain
- Trial name
- NCT01742559
- Testing
- Anterior middle superior alveolar, Supraperiosteal technique
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- State University of Maringá
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