Clinical trials: Local Disease
Adverse Local Tissue Reaction, Total Hip Arthroplasty
ASR-XL Metal-on-Metal 522 Post-Market Surveillance Study
The purpose of this clinical study is to evaluate blood metal ion levels as a function of time of implantation for the ASR-XL MoM system.
- Trial name
- NCT01884532
- Testing
- ASR-XL Metal-on-Metal
- Where
- 7 sites in United States
- Volunteers
- 146 people
- Sponsor
- DePuy Orthopaedics
Degenerative Disc Disease
A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion
The primary objective of the study is to assess the overall efficacy of a single intervertebral local administration of AGA111 in patients with degenerative disc disease undergoing lumbar interbody fusion.
- Trial name
- NCT06115512
- Testing
- AGA111
- Where
- 35 sites in China
- Volunteers
- 412 people
- Sponsor
- Angitia Biopharmaceuticals
Malocclusion
Micro-osteoperforations and Tooth Movement
The purpose of this study is determine the effect the Microosteoperforation (MOPs) using the miniscrew on the rate tooth movement.
- Trial name
- NCT02473471
- Testing
- Micro-osteoperforation
- Where
- Jordan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Pain
Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery
The purpose of this study is to determine if the infusion of the local anesthetic ropivacaine (a numbing medicine) and the non-steroidal anti-inflammatory drug ketorolac (a pain killer similar to ibuprofen) through a catheter…
- Trial name
- NCT02829944
- Testing
- Ropivacaine, Ketorolac
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Duke University
Pain, Postoperative, Surgical Wound
Transversus Thoracis Muscle Plane Block for Sternotomy Pain in Cardiac Surgery
Sternotomy pain is usually significant after cardiac surgery. Analgesic options for sternotomy in cardiac surgery are often limited. Poorly controlled acute pain is an important factor to development of chronic postsurgical pain.
- Conditions
- Pain, Postoperative, Surgical Wound, Cardiac Event
- Trial name
- NCT04596163
- Testing
- Transversus thoracis muscle plane block
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- Chinese University of Hong Kong
Knee Arthropathy
Defining the Optimal Location to Place an Adductor Canal Block
The aim of the current project is to address a gap in the existing literature related to optimal placement of local anesthetic for an adductor canal (AC) block.
- Trial name
- NCT04298476
- Testing
- Placement of an adductor canal nerve block
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Drexel University
Diabetes Mellitus Type 2
Intraseptal and Periodontal Ligament Anaesthesia for Tooth Extraction in Patients With Type 2 Diabetes
The goal of this clinical trial is to compare two local anesthesia techniques, intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA), in patients with controlled type 2 diabetes mellitus undergoing tooth…
- Trial name
- NCT07647406
- Testing
- Intraseptal anaesthesia (ISA), Periodontal ligament anaesthesia (PLA)
- Where
- Serbia
- Volunteers
- 120 people
- Sponsor
- University of Business Academy in Novi Sad, Serbia
Local Anesthesia
Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar Nerve Block
The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for anterior and middle superior alveolar nerve (AMSA)…
- Trial name
- NCT02440347
- Testing
- Computer controlled anesthetic delivery by Anaeject, Conventional anesthetic delivery by carpule syringe
- Where
- Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Hashimoto Thyroiditis, Goiter
Role of Total Thyroidectomy in Relieving Local Symptoms in Hashimoto's Thyroiditis
This study aims to evaluate the role and effectiveness of total thyroidectomy in relieving compressive and local symptoms (such as dysphagia, dyspnea, and anterior neck pain/discomfort) in patients with Hashimoto's thyroiditis…
- Trial name
- NCT07852026
- Testing
- Total Thyroidectomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Dental Anxiety, Pain Management
Impact of Local Anesthesia Techniques on Children's Dental Treatment Experience
compare the effectiveness of several local anesthetic delivery systems in managing pain, anxiety, behavior, and vital signs among pediatric dental patients.
- Conditions
- Dental Anxiety, Pain Management, Pediatric Dentistry
- Trial name
- NCT07106138
- Testing
- Conventional syringe injection, Star Pen, Comfort-In
- Where
- Syria
- Volunteers
- 112 people
- Sponsor
- Latakia University
Procedural Pain
The Effect of Audio Book and Local Vibration on Pain and Fear in Intramuscular Injection in Children
The study is conducted based on a randomized controlled experimental design to determine the effect of an audio book and local vibration on intramuscular injection in pediatric emergency unit patients aged 4-6 years on pain and…
- Trial name
- NCT06354608
- Testing
- Audio Book Group, Local Vibration Group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis
- Trial name
- NCT05029726
- Testing
- Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- John O'Toole
Lidocaine, Bupivacaine
Comparing the Efficacy of Local Anesthetics in Mohs Surgery
Mohs surgery is a very effective option in removing non-melanoma skin cancers, as the tissue being removed is analyzed the same day.
- Conditions
- Lidocaine, Bupivacaine, Mohs Surgery, Anesthetic
- Trial name
- NCT03871478
- Testing
- Lidocaine, Bupivacaine, Lidocaine and Bupivacaine
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Ottawa Hospital Research Institute
Local Recurrence of Malignant Tumor of Prostate, Radiotherapy
Stereotactic Re-irradiation of Local Recurrences of Prostate Cancer After Radiotherapy
The goal of this clinical study is to evaluate the toxicity and efficacy of re-irradiation using focal stereotactic body radiotherapy (SBRT) in patients with local recurrence of prostate cancer after definitive or post-operative…
- Trial name
- PROSTARE (NCT06201078)
- Testing
- Stereotactic Body Radiotherapy
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Biotinidase Deficiency
Neonatal Screening of Biotinidase Deficiency: Genotype-phenotype Correlation and Clinical Follow-up
Retro-prospective, single-centre, observational study conducted at the Endocrine-Metabolic Diseases Center of the Pediatrics Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy.
- Trial name
- NCT06723925
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Chronic Periodontitis
Evaluation of Local Delivery of Aloe Vera Gel as an Adjunct to Non-surgical Treatment in Patients With Chronic Periodontitis
Aim of the current study was to evaluate the effect of Aloe vera gel as an adjunct to scaling and root planing (SRP) in the management of chronic periodontitis.
- Trial name
- NCT04615585
- Testing
- Aloe vera after SRP, Scaling and root planing (SRP)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nourhan M.Aly
Periodontitis, Metabolic Syndrome
Effects of Periodontal Therapy in Patients With Metabolic Syndrome
A 6-month, parallel-arm, investigator-masked, randomized clinical trial was conducted in patients with MetS and severe periodontitis.
- Trial name
- MetS (NCT03960216)
- Testing
- Scaling and root planning, Supragingival Prophylaxis
- Volunteers
- 60 people
- Sponsor
- Universidad Complutense de Madrid
Cerebral Ischemia-Hypoxia
Effect of Sedatives on Regional Cerebral Oxygen Saturation
Compare the changes of regional cerebral oxygen saturation during midazolam or dexmedetomidine sedation for spinal anesthesia in the elderly patients who undergoing femur surgery.
- Trial name
- 2 (NCT02966743)
- Testing
- Midazolam, Dexmedetomidine
- Where
- South Korea
- Sponsor
- Gachon University Gil Medical Center
Postoperative Pain
Transversus Abdominis Plane Blocks for Infants and Children for Postoperative Pain Control
After undergoing hernia surgery, hydrocelectomy or lower abdominal surgery, a child may experience some amount of pain in the post-operative period.
- Trial name
- NCT01559740
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Breast Cancer, Chemotherapy Effect
Simvastatin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response and Tumor-Free Margin in Locally Advanced Breast Cancer
Introduction: Neoadjuvant chemotherapy (NACT) has been the standard therapy for treating patients with locally advanced breast cancer (LABC). Doxorubicin-based regimen showed a clinical response for 70-80%.
- Trial name
- NCT04418089
- Testing
- Simvastatin 40mg
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Indonesia
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