Clinical trials: Local Disease
Pain, Postoperative
Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty
Total shoulder arthroplasty (TSA) is considered to be a major surgical procedure resulting in severe postoperative pain, especially in the first 48 hours after surgery.
- Trial name
- NCT02876055
- Testing
- Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypertension
The Effect of Local Cold Application on Hypertension
This study will be conducted to evaluate the effect of local cold application to the nape of the neck on systolic blood pressure, diastolic blood pressure, heart rate, heart rate pressure and headache.
- Trial name
- NCT04998526
- Testing
- Experimental group
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ataturk University
Genitourinary Syndrome of Menopause
Efficacy of the Use of Cellular Matrix/ A-CP-HA Kit
This study is a randomized, controlled, non-inferiority trial, that will be performed on 192 women on Menopause (absence of menstruation for at least 12 months), with diagnostic of genitourinary syndrome of menopause (SGM) and a…
- Trial name
- CellularMatrix (NCT06425978)
- Testing
- Cellular Matrix / A-CP-HA Kit, Local estrogen therapy (Blissel, estriol 50 micrograms/g vaginal gel)
- Where
- Spain
- Volunteers
- 192 people
- Sponsor
- Fundación Santiago Dexeus Font
Local Infiltration, Anesthesia
Painless Local Anaesthesia With Bicarbonate Admixture
This study examines whether the injection of local anesthesia mixed with sodium bicarbonate in the ratio of 3:1 creates a less burning sensation and is as effective regarding the anesthetic effect as in the ratio of 9:1.
- Trial name
- NCT03238625
- Testing
- Lidocaine and sodium bicarbonate, Lidocaine, Sodium cloride 0.9%
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Venous Malformation, Low Flow, Venous Malformations
Acetylsalicylic Acid Versus Placebo as an add-on Treatment to Local Non-steroidal Anti-inflammatory Drug for the Management of Thrombotic Episodes in Superficial Venous Malformations in Children Aged 6 to 17 Years.
Superficial venous malformations (SVMs) are rare congenital anomalies that present as bluish masses. These masses may be focal, with limited skin involvement, or segmental, with more extensive involvement.
- Trial name
- ASPIRIN (NCT07663825)
- Testing
- AAS at anti-inflammatory doses from 3 days to 14 days., Application of Diclofenac gel 1% twice a day
- Where
- 6 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Tours
Hospital Adverse Event
Impact on the Adverse Event (AE) Incidence of Two Types of Experience Feedback on AE Analyzed During Local Morbidity Mortality Reviews
After implementing a French version of a trigger tool validated for computerized detection of adverse events in patient's medical record, the study will be performed in three parallel randomized arms of three identical…
- Trial name
- RMM Simulation (NCT02771613)
- Testing
- Multi professional in situ simulation, Large diffusion of information
- Where
- France
- Volunteers
- 144,000 people
- Sponsor
- Hospices Civils de Lyon
Rectovaginal Fistula, Crohn Disease
Allogenic Stem Cells Derived From Lipoaspirates for the Treatment of Recto-vaginal Fistulas Associated to Crohn's Disease (ALOREVA)
The purpose of this study is to determine safety and efficacy of allogenic eASCs (expanded adult stem cells) for the treatment of recto-vaginal fistula in patients with Crohn´s disease.
- Trial name
- ALOREVA (NCT00999115)
- Testing
- Expanded allogenic adipose-derived adult stem cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in Lymph Node
Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement
This phase II trial studies how well encorafenib and binimetinib work before surgery in treating patients with BRAF V600-mutated stage IIIB-D melanoma that has spread to the lymph nodes.
- Conditions
- Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in Lymph Node, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
- Trial name
- NCT04221438
- Testing
- Binimetinib, Conventional Surgery, Encorafenib
- Where
- 10 sites in United States
- Volunteers
- 3 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Postoperative Local Analgesia
A Study on the Bioequivalence of Bupivacaine Liposome Injection in Humans
This study aims to investigate the pharmacokinetics of bupivacaine liposomal injection (test preparation) in healthy subjects. The manufactured liposomal bupivacaine injection (EXPAREL®) was used as the reference formulation to…
- Trial name
- NCT07279155
- Testing
- Bupivacaine Liposome Injection T preparation, Bupivacaine Liposome Injection R preparation
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Peritoneal Carcinomatosis
Register Study of Patients With Peritoneal Carcinomatosis Treated With PIPAC (Pressurized Intra-peritoneal Aerosol-Chemotherapy)
The study will follow up patients with peritoneal carcinomatosis from colorectal, ovarian, gastric, pancreatic cancers and primary peritoneal tumors and undergoing a diagnostic laparoscopy / laparotomy, a PIPAC as single dose or…
- Trial name
- PIPAC_01 (NCT03100708)
- Testing
- PIPAC
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Cervical Radiculopathy
Does Low-does Cervical Epidural Lidocaine Cause Transient Weakness?
"Does low-does cervical epidural lidocaine cause transient weakness?"
- Trial name
- NCT03382925
- Testing
- cervical interlaminar with lidocaine, cervical interlaminar with normal saline, Lidocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Utah
Healthy
Rendering of a Local 1g Environment for Enhanced Motor Learning in Altered Gravity
Human motor adaptation is crucial to adapt to new environments, such as altered gravity. Dexterous manipulation and fine movements in space require learning new coordinated motor actions.
- Trial name
- Sim1g (NCT03978910)
- Testing
- measurements of the accuracy of the reaching movements
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Osteoarthritis
Local Infiltration Analgesia or Intrathecal Morphine in Total Knee Arthroplasty
The purpose of this study is to determine whether local infiltration analgesia is more effective than intrathecal morphine in reducing postoperative pain in total knee arthroplasty.
- Trial name
- NCT00992082
- Testing
- ropivacaine, ketorolac and epinephrine, morphine
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Cerebral Palsy (CP)
Local Vibration for Drooling in Children With Cerebral Palsy
This randomized-controlled trial evaluates local vibration therapy for drooling and orofacial muscle biomechanics in children with cerebral palsy.
- Trial name
- NCT07626424
- Testing
- Local Vibration Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Bitlis Eren University
Actinic Keratoses
Frequency and Intensity of Local Reactions in Patients Treated With 4% 5-FU vs 4% 5-FU Associated With an Emollient Cream: a Randomised, Controlled Clinical Trial
Transient local skin reactions with topical Actinic Keratosis treatments such as 5-FluoroUracil (5-FU) often lead to non-adhesion from patients and thus to treatment failure.
- Trial name
- NCT04875026
- Testing
- 5-fluorouracil 4% (Tolak), Dexeryl
- Where
- 27 sites in France, Germany and 2 more
- Volunteers
- 146 people
- Sponsor
- Pierre Fabre Medicament
Anesthesia, Local
Anesthetic Efficacy of PECS II Block and Parasternal Block
The study evaluate the anesthetic efficacy of Pecs II block II and parasternal block during quadrantectomy with or without axillary dissection, in breast cancer surgery
- Trial name
- NCT03016117
- Testing
- Pecs II block and parasternal block
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- San Salvatore Hospital of L'Aquila
Periodontal Diseases
Evaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodontal Disease
The goal of this clinical trial is to learn if the herbal gel is more effective as compared to placebo in reducing periodontal inflammation in patients with periodontal disease.
- Trial name
- NCT07135674
- Testing
- herbal drug
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Rungta College of Dental Sciences and Research
Opioid Use, Postoperative Pain
Comparison of Postoperative Analgesia Methods in Elective Cesarean Section Surgeries
Since many intravenous anesthetic agents administered to the mother can cross the placental barrier and cause fetal side effects, multimodal analgesia strategies with peripheral nerve blocks are preffered with greater safety in…
- Trial name
- NCT06425718
- Testing
- Postoperative Pain Management Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Marmara University
Nasopharyngeal Carcinoma
Study to Evaluate Induction Chemotherapy Using Docetaxel, Cisplatin and Fluorouracil in Concurrence With Intensity-modulated Radiotherapy for Local Recurrent Nasopharyngeal Carcinoma (NPC)
Study Objective: Primary 1. To evaluate the complete response (CR) rate with induction chemotherapy using Docetaxel, Cisplatin and Fluorouracil(TPF) followed by Docetaxel plus Cetuximab (TC) in concurrence with…
- Trial name
- NCT01326559
- Testing
- Docetaxel, Cisplatin, 5-FU and Cetuximab
- Where
- 4 sites in China
- Volunteers
- 33 people
- Sponsor
- Hong Kong Nasopharyngeal Cancer Study Group Limited
Osteo Arthritis, Cellulitis
Continuous Regional Anesthesia for Septic Limb Orthopedic Surgery
This study aims to assess the safety of using continuous regional anesthesia for post-operative analgesia during septic limb orthopedic surgery.
- Trial name
- ACOSM (NCT01947660)
- Testing
- Systemic analgesia + Continuous regional anesthesia, Systemic analgesia
- Where
- France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Strasbourg, France
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