Clinical trials: Local Disease
Esophageal Squamous Cell Carcinoma
A Randomized Controlled Trial Evaluating of Prophylactic Irradiation in CRT for cT1bN0M0 ESCC
This study is conducted to investigate whether modified chemoradiotherapy with elective nodal irradiation reduces the locoregional recurrence that cannot be completely resected by salvage endoscopic resection and preserve…
- Trial name
- ARMADILLO (NCT04328948)
- Testing
- Chemoradiotherapy
- Where
- Japan
- Volunteers
- 280 people
- Sponsor
- National Cancer Center, Japan
Melanoma (Skin)
High-Dose or Low-Dose Interferon Alfa Compared With No Further Therapy Following Surgery in Treating Patients With Stage III Melanoma
RATIONALE: Interferon alfa may interfere with the growth of cancer cells. It is not known whether giving high-dose or low-dose interferon alfa is more effective than no further therapy in treating patients with stage III…
- Trial name
- NCT00002763
- Testing
- recombinant interferon alfa
- Where
- 86 sites in Austria, Belgium and 19 more
- Volunteers
- 1,000 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Breast Cancer
Breast-Conserving Therapy Compared With Mastectomy Followed By Radiation Therapy in Treating Women With Locally Advanced Breast Cancer Previously Treated With Chemotherapy
RATIONALE: Breast-conserving treatments such as radiation therapy or limited surgery are less invasive than mastectomy and may improve the quality of life.
- Trial name
- NCT00028704
- Testing
- conventional surgery, radiation therapy
- Where
- 13 sites in Belgium, Chile and 5 more
- Volunteers
- 26 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Periodontitis
Role of Simvastatin Microsponges in Treatment of Periodontitis
the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentially absorbed.
- Trial name
- NCT04836078
- Testing
- open flap subgingival debridement, Subgingival injection of chitosan 2% gel
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Assiut University
Mixed Venous Oxygen Saturation, Tissue Oxygenation
Validation of Mixed Venous Blood Oxygen Saturation Obtained With a Novel Mathematical Equation
The purpose of this study is to test a new way to measure the oxygen level in the mixed venous blood system (the system that carries blood collected from all over the body to the heart), which is a very important monitoring tool…
- Trial name
- NCT00783952
- Testing
- Cerebral/Somatic Tissue Oximeter device, Pulmonary artery catheter
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Vaginal Hysterectomy
Liposomal Bupivacaine in Vaginal Hysterectomy
The aim of this study is to compare the effects of preemptive analgesia using liposomal bupivacaine mixed with bupivacaine HCl, versus bupivacaine HCl alone for uterosacral ligament injection in patients undergoing vaginal…
- Trial name
- NCT03907033
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Breast Cancer
Reconstruction of Partial Mastectomy Defects With Pectoralis Myo-glandular Local Flap.
Increasing number of breast cancer patients are being treated with conservative surgery; without the need for mastectomy. The cosmetic sequel of breast conservative surgery can be unsatisfactory to the patient and may necessitate…
- Trial name
- NCT04091958
- Testing
- Pectoralis myo-glandular flap reconstruction.
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Chronic Periodontitis
Evaluation of Local Doxycycline in Smokers With Chronic Periodontitis
Summary The aim of this study is to evaluate through clinical, microbiological and immunological parameters using PLGA microspheres (lactic-co-glycolic acid polyacid) containing doxycycline in periodontal therapy in smokers with…
- Trial name
- NCT02726646
- Testing
- Doxycycline, Mechanical debridement
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Campinas, Brazil
Anterior Cruciate Ligament Reconstruction
Periarticular Injection and Hamstring Block Versus Placebo for Pain Control in Anterior Cruciate Ligament Reconstruction
A randomized controlled trial about periarticular injection and hamstring block versus placebo for pain control in anterior cruciate ligament reconstruction
- Trial name
- NCT05248724
- Testing
- periarticular infiltration (50ml) with Ropivacaine Hydrochloride 10 MG/ML (200 mg) + ketorolac tromethamine 30 mg/ml (30 mg) + adrenaline 1mg/ml (300 microgram) + morphine hydrochloride 10mg/ml (5 mg)
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Castilla-La Mancha Health Service
Nerve Blocks, Breast Surgery
Efficacy of Pectoral Nerve Block for Breast Reduction Surgery
The purpose of the study is to evaluate the efficacy of PECS block applied to patients undergoing bilateral breast reduction surgery on postoperative analgesia compared to local infiltration anesthesia.
- Conditions
- Nerve Blocks, Breast Surgery, Postoperative Pain
- Trial name
- NCT03857386
- Testing
- PECS group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Antalya Training and Research Hospital
Critical Illness, Sepsis
Cerebral Oxygen Challenge of Passive Leg Raising Test in Sepsis
Sepsis related cerebral dysfunction was underestimated in critical illness setting, and inflammatory response of brain could not be monitored directly and cerebral oximetry offered information of cerebral dysfunction.
- Conditions
- Critical Illness, Sepsis, Cerebral Injury
- Trial name
- NCT03523169
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Pain, Postoperative
Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy
The purpose of this study is to compare recovery unit and post operation day (POD) 1 pain score in women following elective robotic assisted TLH (RA-TLH) for benign indication with and without local vaginal cuff injection of…
- Trial name
- LAVA (NCT07842159)
- Testing
- Combined Bupivacaine and Exparel, Normal Saline (NS)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- The University of Texas Health Science Center, Houston
Lymphoma, Neuroblastoma
Whole-Body MRI and Conventional Imaging in Detecting Distant Metastases in Young Patients With Solid Tumors or Lymphoma
RATIONALE: New imaging procedures, such as whole-body MRI, may improve the ability to detect metastatic cancer and determine the extent of disease.
- Conditions
- Lymphoma, Neuroblastoma, Sarcoma
- Trial name
- NCT00072488
- Testing
- computed tomography, magnetic resonance imaging, positron emission tomography
- Where
- 21 sites in United States, Canada
- Volunteers
- 226 people
- Sponsor
- American College of Radiology Imaging Network
Perioperative Analgesia, Hip Dislocation, Developmental
PENG Block in Comparison With FICB for Hip Reconstruction in Children
The goal of this clinical trial is to test the hypothesis that performing a Pericapsular nerve group (PENG) block allows for more effective analgesia in the perioperative period during reconstructive surgery on the hip in…
- Trial name
- NCT06210503
- Testing
- Pericapcelar group nerve block, Fascia iliaca compartment block
- Where
- Russia
- Volunteers
- 86 people
- Sponsor
- Saint Petersburg State University, Russia
Osteoarthritis, Hip
3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
Spinal anesthesia is commonly utilized for hip replacement surgery. Different medications used for spinal anesthesia work for different lengths of time.
- Trial name
- NCT03948386
- Testing
- isobaric bupivacaine, hyperbaric bupivacaine, isobaric mepivacaine
- Where
- 2 sites in United States
- Volunteers
- 159 people
- Sponsor
- Thomas Jefferson University
Acute Kidney Injury, Acute Kidney Failure
HEmoFiltration With Citric Acid Anticoagulation
Prospective observational study of all consecutive cardio-vascular surgical patients treated with post-dilution hemofiltration with regional citrate anticoagulation as first-choice anticoagulation method.
- Conditions
- Acute Kidney Injury, Acute Kidney Failure, Renal Replacement Therapy, Hemofiltration
- Trial name
- HEFCAA (NCT03836742)
- Testing
- Hemofiltration with regional citrate anticoagulation
- Where
- Poland
- Volunteers
- 54 people
- Sponsor
- Medical University of Gdansk
Post Operative Pain, Erector Spinae Plane Block
Erector Spinae Plane Block Versus Local Wound Infiltration After Modified Radical Mastectomy
This randomized prospective double blinded study will aim to evaluate the postoperative analgesic effect of ultrasound guided Erector Spinae plane block and local wound infiltration (drain block) for patients scheduled for…
- Conditions
- Post Operative Pain, Erector Spinae Plane Block, Local Infiltration
- Trial name
- NCT06533566
- Testing
- Erector spinae plane block, local wound infiltration
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Tanta University
Breast Cancer
Safety of Breast-Conserving Surgery for Multifocal or Multicentric Breast Cancer
The objective of this observational study is to evaluate the oncological safety of breast-conserving surgery combined with standard postoperative radiotherapy in adult female patients diagnosed with multifocal or multicentric…
- Trial name
- NCT07677956
- Testing
- Breast-conserving surgery, postoperative radiotherapy and individualized adjuvant systemic therapy
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Post Operative Pain
Ketamine and Dexmedetomidine Comparative Study
In this study, the investigators will compare the effect of adding ketamine and dexmedetomidine to bupivacaine in US-guided combined sciatic and femoral nerve blocks as regards the onset and duration of the block, postoperative…
- Trial name
- NCT06032624
- Testing
- combined ultra-sound guided femoral and sciatic nerve block.
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Pyoderma, Pyoderma Gangrenosum
Phase 0/1 Local Application of the Monoclonal Antibody (Mab) sB24M in Patients With Purulent Pyoderma
Phase 0/1 local application of the monoclonal antibody (Mab) sB24M in patients with purulent pyoderma (chronic ulcerative pyoderma) by injection into the affected areas.
- Conditions
- Pyoderma, Pyoderma Gangrenosum, Pyoderma Vegetans, Pyoderma Gangrenosum Surrounding Surgical Stoma
- Trial name
- NCT04895566
- Testing
- Monoclonal antibody (Mab) sB24M
- Where
- 2 sites in Belarus, Latvia
- Volunteers
- 10 people
- Sponsor
- SWISS BIOPHARMA MED GmbH
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