Clinical trials: Local Disease
Hypertension
Chemical Block and Electrical Stimulation of the Carotid Body to Treat Refractory Hypertension
High blood pressure, also referred to as hypertension, affects about 65 million people in the United States alone. Approximately 25 percent of people with hypertension cannot control their high blood pressure, despite the use of…
- Trial name
- NCT02519868
- Testing
- Electrical block, Chemical block
- Where
- Switzerland
- Sponsor
- Eric Albrecht
Cochlear Implant Surgery
Local Anesthesia With Sedation for Cochlear Implant Surgery
ABSTRACT Objectives: The aim of this article is to illustrate the possibility of performing a cochlear implant with local anesthesia and sedation, the anesthesic technique and the advantages of that in comparison to a general…
- Trial name
- IC (NCT01033890)
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- Instituto Paranaense de Otorrinolaringologia
Rheumatoid Arthritis
Preference Methotrexate (MTX) Pre-filled Syringe Versus Pre-filled Pen in Rheumatoid Arthritis (RA)
The primary objective of this study is to assess the number of patients preferring the methotrexate pre-filled pen to the methotrexate pre-filled syringe after 6 weeks of treatment based on a questionnaire
- Trial name
- NCT01793259
- Testing
- methotrexate prefilled pen, methotrexate prefilled syringe
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- medac GmbH
Gingival Recession
Treatment of Local Gingival Recession With an Enamel Matrix Protein Coated Collagen Matrix
The clinical trial studies patients with gingival recession defects (receding gums). The goal of the study is to test whether the additional use of enamel matrix derivatives (EMD), combined with the use of a coronally advance…
- Trial name
- EmdoDerm (NCT05799859)
- Testing
- Use of coronally advanced flap (CAF) and collagen matrix (CM), Use of coronally advanced flap (CAF) and collagen matrix (CM) and additional application of enamel matrix derivatives (EMD).
- Volunteers
- 15 people
- Sponsor
- Medical University of Graz
Pain, Postoperative, Bariatric Surgery Candidate
A Study to Compare Two Techniques for Pain Control After Bariatric Surgery
The purpose of this study is to compare the postoperative pain and other clinical outcomes in patients who, during bariatric surgery, will be injected with a local anesthetic (Ropivacaine) through two different techniques.
- Trial name
- NCT04427059
- Testing
- Transversus Abdominis Plane (TAP) block, Port-Site Infiltration (PSI)
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- Fabio Garofalo
Diaphragmatic Disorder
Different Local Anesthetic Volumes in Brachial Plexus Block
This prospective randomized study will be carried out on 75 patients in our university hospitals presented for shoulder arthroscopy under general anesthesia and ultrasound-guided interscalene brachial plexus block.
- Trial name
- NCT04549779
- Testing
- Low volume interscalene brachial plexus block, Intermediate volume interscalene brachial plexus block, High volume interscalene brachial plexus block
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- Tanta University
Cancer
Improving Cancer Prevention and Control Through Academic-local Public Health Department Partnerships
The purpose of this study is to understand how to leverage structures and processes of academic health department (AHD) partnerships to facilitate implementation of cancer related evidence-based programs and policies (EBPPs).
- Trial name
- AHD (NCT06605196)
- Testing
- Resources and guided facilitation, Existing resources
- Where
- United States
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Post-Operative Pain, Lumbar Laminectomy
HTX-011 in Spinal Surgery
This is a Phase 2, multicenter study in subjects undergoing an open lumbar decompression surgery.
- Trial name
- NCT04911062
- Testing
- Bupivacaine HCI without epinephrine, HTX-011, Luer Lock Applicator
- Where
- 12 sites in United States
- Volunteers
- 32 people
- Sponsor
- Heron Therapeutics
Prostate Cancer
Active Surveillance Plus (AS+): High-intensity Focused Ultrasound (HIFU) in Patients With Localized Prostate Cancer
PSA (Prostate-specific antigen) testing has significantly increased the number of men diagnosed with prostate cancer (PCa) and especially patients with low and intermediate risk disease.
- Trial name
- NCT04549688
- Testing
- high-intensity focused ultrasound, HIFU
- Where
- Norway
- Volunteers
- 250 people
- Sponsor
- The Hospital of Vestfold
Breast Cancer, Chemotherapy Effect
Evaluation of Recurrence Risk Factors in Locally Advanced Breast Cancer Patients Underwent Neoadjuvant Chemotherapy.
INTRODUCTION Breast cancer (BC) is the leading cause of cancer-related death in women. Since the early 1980s, the implementation of screening programs has reduced the number of patients diagnosed with locally advanced breast…
- Conditions
- Breast Cancer, Chemotherapy Effect, Triple Negative Breast Cancer, Recurrence, Local Neoplasm
- Trial name
- NEORISK (NCT06441240)
- Testing
- MRI
- Where
- Italy
- Volunteers
- 933 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco
Asthma, COPD
MagniXene MRI Use in Patients With Asthma and COPD to Assess Regional Lung Function by Delineating Ventilation Defects
The purpose of this clinical trial is to demonstrate hyperpolarized xenon (HXe) as a medical imaging drug (agent) for Magnetic Resonance Imaging (MRI) of the human lung ventilation.
- Conditions
- Asthma, COPD, Healthy
- Trial name
- HXe-VENT (NCT01833390)
- Testing
- HXe MRI lung ventilation
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Xemed LLC
Pain
Pain Management in Response to Exparel vs. Standard Bupivicaine
This study is looking to evaluate the efficacy of liposomal bupivicaine (Exparel) on decreasing the amount of consumed pain medications.
- Trial name
- VATS Exparel (NCT02499159)
- Testing
- Liposomal Bupivicaine, 0.25% standard bupivicaine
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Inova Health Care Services
Health Behaviour
Evaluating Specific Plans to Increase Smoking Quit Attempts in Prison
Tobacco use is the greatest cause of ill health and early mortality, and smoking is the main contributor to around 75,000 deaths a year in England.
- Trial name
- NCT02567097
- Testing
- Self-Incentive
- Where
- United Kingdom
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hospital Adverse Event
Impact on the Adverse Event (AE) Incidence of Two Types of Experience Feedback on AE Analyzed During Local Morbidity Mortality Reviews
After implementing a French version of a trigger tool validated for computerized detection of adverse events in patient's medical record, the study will be performed in three parallel randomized arms of three identical…
- Trial name
- RMM Simulation (NCT02771613)
- Testing
- Multi professional in situ simulation, Large diffusion of information
- Where
- France
- Volunteers
- 144,000 people
- Sponsor
- Hospices Civils de Lyon
Ablation Techniques, RFA, Ablation Treatment
Efficacy and Safety of RFA vs MWA for Treatment of Large Benign Thyroid Nodules, RCT
We conduct a multi-institutional randomized control trial of RFA and MWA for the primary treatment of large, benign nodules. Adult patients >/=18 years of age who have a solitary thyroid nodule ≥20ml in volume who presents to 1)…
- Conditions
- Ablation Techniques, RFA, Ablation Treatment, Benign Thyroid Nodules, Local Anaesthesia
- Trial name
- NCT07804862
- Testing
- Radiofrequency ablation alone, Microwave ablation
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The University of Hong Kong
Pain, Postoperative, Shoulder Osteoarthritis
Effective Pain Management During Shoulder Replacement Surgery With EXPAREL
The purpose of this study is to examine the effectiveness of post-operative pain control of local infiltration (LIA) of EXPAREL administration to ropivacaine administered via continuous interscalene nerve block (CINB) for…
- Trial name
- NCT03474510
- Testing
- local infiltration of liposomal bupivacaine, continuous infusion of ropivacaine interscalene nerve block
- Where
- United States
- Sponsor
- TriHealth Inc.
Diabetes Mellitus, Type 2
A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in France, as Part of Local Clinical Practice (SURE FRANCE)
The purpose of the study is to collect information on how semaglutide works in real world patients. Participants will get semaglutide prescribed by their study doctor. The study will last for about 6 to 8 months.
- Trial name
- SURE FRANCE (NCT04083820)
- Testing
- semaglutide
- Where
- 53 sites in France
- Volunteers
- 521 people
- Sponsor
- Novo Nordisk A/S
Brain Injuries
Clinical Pilot Study to Evaluate a New Multi-parameter Neuromonitoring Device in Brain-injured Patients
Clinical pilot study to evaluate a new multi-parameter neuromonitoring device that allows the measurement of regional cerebral blood flow (rCBF), intracranial pressure (ICP), brain temperature monitoring and ventricular…
- Trial name
- CBMS FIH (NCT03249220)
- Testing
- Placement of the CBMS Probe
- Where
- 2 sites in Switzerland
- Volunteers
- 1 people
- Sponsor
- Carag AG
Carpal Tunnel Syndrome (CTS), Chronic Pain
Ultrasound-Guided Injection vs Intramuscular Steroid for Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common and disability-causing entrapment neuropathy; however, a standardized protocol for first-line management has yet to be established.
- Trial name
- NCT06725420
- Testing
- Ultrasound-guided local Injection, Intramuscular Steroid Injection, Splinting
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
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