Clinical trials: Local Disease
Kidney Stone, Surgery
Regional Erector Spinae Analgesic Block vs Standard of Care Undergoing Percutaneous Nephrolithotomy
The purpose of this study is to determine if adding a spinal block (medicine that will numb parts of the body to block pain) along with standard pain control at the incision site will decrease the need for narcotics for pain…
- Trial name
- NCT04663269
- Testing
- 4mg PF Dexamethasone, Control Test
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Genitourinary Syndrome of Menopause
Changes in Neighbouring Microbiota in Genitourinary Syndrome
Genitourinary syndrome (GUS) is a disease seen in menopause, which significantly reduces the quality of life of patients. Microbiota studies in GUS are mostly related to vaginal microbiota.
- Trial name
- NCT06633705
- Testing
- Vaginal Cream with Applicator
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Koc University Hospital
DeQuervain's Tenosynovitis
Local Corticosteroid Injection Versus Open Surgical Release in De Quervain Tenosynovitis: A Single-Center Study
This quasi-experimental study compared pain outcomes following local corticosteroid injection (CSI) versus open surgical release in 100 patients with clinically confirmed De Quervain tenosynovitis unresponsive to conservative…
- Trial name
- NCT07683429
- Testing
- Triamcinolone acetonide with lidocaine, Open surgical release of first dorsal extensor compartment
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Rawalpindi Teaching Hospital, District Headquarter Hospital, Rawalpindi
Pain, Postoperative
Efficacy of Liposomal Bupivacaine Versus 0.25% Bupivacaine for Laparoscopic Urologic Surgery
A prospective, randomized comparison of bupivacaine to liposomal bupivacaine given by local injection at all the wound sites in patients undergoing robotic-assisted or laparoscopic urologic surgeries in an effort to determine…
- Trial name
- NCT02222129
- Testing
- Bupivacaine, liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Knight, Richard, M.D.
Prostate Cancer
Buffered Lidocaine for Reducing Pain in Patients Undergoing Prostate Biopsy, BURN Trial
This phase I/II trial examines if buffered lidocaine reduces the pain that patients may experience during prostate biopsy. Prostate biopsies are typically performed awake, in the office, with only local anesthetic.
- Trial name
- BURN (NCT06661902)
- Testing
- Buffered Lidocaine (1% Lidocaine + 8.4% Sodium Bicarbonate, in a 3:1 ratio), Lidocaine, Biopsy of Prostate
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Washington
Healthy, Healthy Subjects (HS)
Static Stretching Reshapes Post-RT Recovery
This experimental study investigates the acute cardiovascular and local recovery to a single session of resistance training, with and without additional static stretching, compared with a resting control condition.
- Conditions
- Healthy, Healthy Subjects (HS), Cardiovascular Adaption, Stretching
- Trial name
- NCT07649785
- Testing
- Resistance Training, Resistance training + Static Stretching
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Arthroplasty, Replacement, Knee, Analgesia
Adductor Canal Block and Multimodal Local Infiltration Analgesia in Patients Receiving Total Knee Arthroplasty
Total knee arthroplasty (TKA) is associated with moderate to severe pain after operation. There are twenty thousand patients undertaking TKA annually in Taiwan, and the average length of hospital stay is about seven to ten days.
- Conditions
- Arthroplasty, Replacement, Knee, Analgesia, Rehabilitation
- Trial name
- NCT05439343
- Testing
- Pain scores (numerical rating scale at rest and motion), Secondary outcomes
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Radiation-Induced Intestinal Injury
Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury
Due to the increasing number and prolonged survival of malignant tumor patients treated with radiotherapy, the complication, such as acute radiation-induced intestinal injury, has become increasingly significant.
- Trial name
- NCT06410443
- Testing
- Dexamethasone, Antibiotics, probiotics, vitamins, antidiarrheal drugs, enteral nutrition, and endoscopic argon plasma coagulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Shenyang Military Region
Congenital Heart Disease
Paravertebral Nerve Blocks in Neonates
This study is a prospective, randomized, non-blinded clinical trial examining the use of paravertebral peripheral nerve block in the neonatal and infant populations.
- Trial name
- NCT03408340
- Testing
- Paravertebral Nerve Block, Standard of Care Anesthesia
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Emory University
Psoriasis, Contact Dermatitis of Hand
An Open-label Controlled Trial: Effectiveness of Balneotherapy in Palmoplantar Psoriasis and Contact Dermatitis.
Patients who had an indication for phototherapy were included in this study. The treatment was used as a monotherapy protocol. The standard protocol for bathing PUVA involved applying 0.01% bath psoralen for 15 minutes, while the…
- Trial name
- NCT06458868
- Testing
- salt water or tap water before UVA
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara University
Pain,Postoperative
Modified Thoracoabdominal Nerve Block(M-TAPA) in Total Laparoscopic Hysterectomies
The aim of the study is comparing the postoperative effects of ultrasound-guided Modified Perichondrial Approach to Thoracoabdominal Nerves (M-TAPA) block for postoperative pain control after total laparoscopic hysterectomy.
- Trial name
- NCT06601413
- Testing
- M-TAPA Block, Trocar site local anesthetic infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Gulhane Training and Research Hospital
Hepatocellular Carcinoma, Liver Neoplasms
Enhanced Radiofrequency Ablation for Recurrent HCC Post-TACE Using Twin Internally Cooled-Perfusion Electrodes
This single-center, prospective study evaluates the therapeutic outcomes of saline-augmented bipolar radiofrequency ablation (RFA) with twin internally cooled-perfusion (TICP) electrodes for treating recurrent hepatocellular…
- Trial name
- ERFA (NCT07192172)
- Testing
- Bipolar radiofrequency ablation using twin internally cooled perfusion electrodes
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Paroxysmal Atrial Fibrillation
Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation
This prospective, multicenter, randomized, controlled, noninferiority trial will compare local anesthesia with conscious sedation and general anesthesia in patients undergoing pulsed field ablation for paroxysmal atrial…
- Trial name
- PULSE-SED (NCT07877519)
- Testing
- Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System
- Where
- China
- Volunteers
- 390 people
- Sponsor
- China National Center for Cardiovascular Diseases
Radius Fracture Distal
WALANT in Distal Radius Fracture Osteosynthesis
The purpose of this study is to assess the applicability and potential benefits of Wide Awake Local Anesthesia No Tourniquet (WALANT) or Local Anesthesia No Tourniquet ("LANT) versus locoregional anesthesia (LRA) and tourniquet…
- Trial name
- NCT05421000
- Testing
- WALANT, Locoregional anesthesia and tourniquet
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hospital Arnau de Vilanova
Kidney Replacement Disorder
Anticoagulation and Activation - Comparison in Continuous Renal Replacement Therapy
Actual clinical practice predominantly makes use of heparin (systemically) or citrate regionally as anticoagulation in the extracorporeal circulation for renal replacement therapy.
- Trial name
- NCT01276392
- Where
- Germany
- Sponsor
- Klinik für Anästhesiologie
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease (COPD)
Measurements Before and After Participation in a Health Intervention Programme in Halsnaes Municipality
Based on the Danish Health Authority's quality standards for municipal prevention services for citizens with chronic diseases, Steno Diabetes Center Copenhagen (SDCC), Halsnaes Municipality, North Zealand Hospital, and others…
- Conditions
- Type 2 Diabetes, Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Disease
- Trial name
- NCT07641309
- Where
- Denmark
- Volunteers
- 194 people
- Sponsor
- Steno Diabetes Center Copenhagen
Postoperative Pain
Intraoperative Local Anaesthetic and Postoperative Pain
Background: Intraoperative wound infiltration with local anaesthetic is commonly used. Apart from the obvious immediate action it has been supported that a possible down regulation of pain receptors may lead to longer effects.
- Trial name
- Pain-1 (NCT02171299)
- Testing
- Wound infiltration with local anaesthetic, Ropivacaine
- Where
- Greece
- Volunteers
- 400 people
- Sponsor
- Hellenic Red Cross Hospital
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics IIIb
The purpose of this study are to compare the efficacy of two different commercially available local anesthetics on AFXL pretreated skin and to assess the role of the application time in this technique.
- Trial name
- NCT03279757
- Testing
- AHES 5 minutes, AHES 15 minutes, AHES 25 minutes
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Bladder Cancer
Intravesical BCG Administration to Patients With Invasive Bladder Cancer
Patients with invasive bladder cancer will be given 3-6 treatments (based on treatment response) BCG intravesically followed by a cystectomy.
- Trial name
- NCT02365207
- Testing
- BCG strain of Mycobacterium bovis
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Pain, Postoperative
Preemptive Local Anesthesia in Vaginal Surgery
Preemptive analgesia is an intervention which provides an anesthetic prior to initiating a painful stimulus. This trial is examining the effects of a local anesthetic given at the point of innervation prior to performing a…
- Trial name
- NCT00318292
- Testing
- bupivacaine and epinephrine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.