Clinical trials: Local Infiltration, open to volunteers
Acute Myocardial Infarction
Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion injury in AMI patients.
- Trial name
- tSGM-AMI (NCT06947135)
- Testing
- Morphine
- Where
- 3 sites in China
- Volunteers
- 166 people
- Sponsor
- The Second Hospital of Anhui Medical University
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital
Postoperative Pain
Transversus Abdominis Plane Block Versus Wound Infiltration for Pulmonary Function Preservation Following Laparoscopic Living Donor Nephrectomy
This study compares two pain control techniques in patients undergoing laparoscopic kidney donation surgery: transversus abdominis plane (TAP) block versus wound infiltration with local anesthetic.
- Trial name
- TAPWIN (NCT06837909)
- Testing
- Transversus abdominis plane (TAP) block, Wound infiltration
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rabin Medical Center
Knee Arthroplasty, Total
BLOCK-study: Better Local Orthopedic Pain Control After Knee Arthroplasty
The goal of this study is to compare the anesthetic combination iPACK with femoral triangle block versus surgical LIA for unilateral TKA.
- Trial name
- BLOCK (NCT06746168)
- Testing
- Locoregional anesthesia, Local Anesthetic Ropivacaine
- Where
- Belgium
- Volunteers
- 210 people
- Sponsor
- Jessa Hospital
Patients Undergoing Arthroscopic Knee Surgery
Evaluation of the Effectiveness of iPACK and Adductor Canal Blocks on Patients Undergoing Arthroscopic Knee Surgery
Arthroscopic knee surgery is one of the most commonly performed procedures in orthopedic surgery. More than 50% of patients experience moderate to severe pain after the operation.
- Trial name
- NCT07002580
- Testing
- IPACK and adductor canal block with Bupivacaine 0.25%, Spinal Anesthesia with Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sakarya University
Solitary Bone Plasmacytoma, Plasmacytoma of Bone
Radiation Combined With BCMA/CD3 Bispecific Antibody Therapy for Solitary Bone Plasmacytoma With Mild Bone Marrow Infiltration
This is a prospective, single-arm, single-center clinical trial designed to evaluate the safety and efficacy of radiation combined with a BCMA/CD3 bispecific antibody (CM336) in patients with solitary bone plasmacytoma (SBP) with…
- Conditions
- Solitary Bone Plasmacytoma, Plasmacytoma of Bone, Plasma Cell Disorders
- Trial name
- NCT07115667
- Testing
- BCMA/CD3 bispecific antibody (CM336)
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Joint Diseases, Joint Pain
Subsartorial Nerve Block and Femoral Nerve Block in Total Knee Arthroplasty
The goal of this clinical trial is to compare two different types of nerve blocks in patients undergoing surgery for primary Total Knee Arthroplasty.
- Trial name
- NCT06074744
- Testing
- SSNB + IPACK, FNB + IPACK
- Where
- Switzerland
- Volunteers
- 144 people
- Sponsor
- Luzerner Kantonsspital
Breast Surgery, Mammaplasty
The Quest for Opioid-Free Analgesia in Reduction Mammoplasty: A Comparative Analysis of PECS, SAP Blocks, and Tumescent Infiltration
Reduction mammoplasty is associated with significant early postoperative pain due to the extent of the incision and glandular resection.
- Trial name
- NCT07811323
- Testing
- PECS II block, SAPB block, Tumescent local anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziantep City Hospital
Hip Fractures, Arthroplasty, Replacement, Hip
PENG Block + LIA For Endoprosthesis Surgery
The goal of this clinical trial is to learn if a new local anesthesia technique can control pain as well as the standard spinal anesthesia for adults having hip endoprosthesis surgery.
- Conditions
- Hip Fractures, Arthroplasty, Replacement, Hip, Pain, Postoperative, Anesthesia and Analgesia
- Trial name
- PENG 360° (NCT07239817)
- Testing
- Pericapsular Nerve Group Blocks with Local Infiltration Analgesia, spinal anesthesia
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Gaetano Pini-CTO
Local Infiltration
Hyaluronidase Enzymes and Local Anesthesia
For both groups, local anaesthesia will be administered by one single surgeon and the extraction will be performed by another single surgeon across all subjects.
- Trial name
- NCT06980363
- Testing
- traditional inferior alveolar nerve block by articaine, hyaluronidase plus articain buccal infilteration
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Video-assisted Thoracoscopic Surgery (VATS), Pain Management
The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy. It is reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine, Local Injection
- Trial name
- NCT07432711
- Testing
- Bupivacaine hydrochloride, Liposomal bupivacaine plus bupivacaine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Tiantan Hospital
Laparoscopic Sleeve Gastrectomy
Efficacy of Ultrasound-guided External Oblique Intercostal Plane Block Versus Port-site Local Anesthetic Infiltration for Postoperative Analgesia and Pulmonary Function After Laparoscopic Sleeve Gastrectomy
Obesity poses severe global health risks and induces complex cardiorespiratory alterations, making perioperative care critical. For patients with morbid obesity, Laparoscopic Sleeve Gastrectomy (LSG) is the most effective…
- Trial name
- NCT07816055
- Testing
- Port-Site Local Anesthetic Infiltration, External Oblique Intercostal Block
- Volunteers
- 54 people
- Sponsor
- Assiut University
Surgical Site Infection (SSI)
Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy
Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty/infected abdominal conditions.
- Trial name
- NCT07696819
- Testing
- Levofloxacin
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Infiltration of Peripheral IV Therapy, Extravasation
Peripheral Venous Catheter Infiltration and Extravasation
This study aims to evaluate the effect of video-supported education, prepared for pediatric nurses, on their knowledge, attitudes, and perceived professional competence regarding peripheral venous catheter (PVC) infiltration and…
- Trial name
- Extravasation (NCT07545031)
- Testing
- video-assisted peripheral venous catheter infiltration and extravasation training
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Chronic Neck Pain
Phrenic Nerve Infiltration in Neck Pain
Neck pain frequently present comorbidities in peridiaphragmatic organs. The innervation of these organs include the phrenic nerve. It is known that peridiaphragmatic organs trigger referred pain in the neck area.
- Trial name
- PAINOMICS (NCT05605639)
- Testing
- Bupivacaine
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- University of Seville
Resting Visual Analog Scale (VAS) Pain Score
Liposomal Bupivacaine vs Ropivacaine for Post-hemorrhoidectomy Analgesia
This is a single-center, prospective, randomized, double-blind controlled trial comparing the analgesic efficacy, quality of recovery, and safety of perianal wound infiltration with multivesicular liposomal bupivacaine (266 mg)…
- Trial name
- NCT07795203
- Testing
- Liposomal Bupivacaine (EXPAREL®)/Bupivacaine, Ropivacaine Hydrochloride
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Tongliao City People's Hospital
Drop Foot
Can the Phoenix Sign be Elicited With D5W
To determine if the Phoenix sign can be reliably elicited with non-guided subcutaneous infiltration of D5W (5% Dextrose in Water) in patients with subclinical weakness of the extensor hallucis longus (EHL) muscle.
- Trial name
- NCT07568470
- Testing
- Infiltration of D5W
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- US Neuropathy Centers
Pain, Post Endodontic Pain
Pain During Infiltration Injection in Anterior Maxillary Region by Transcodent Painless Needle Tips Versus Regular Needle Tips
This randomized split-mouth controlled clinical trial will compare pain experienced during anterior maxillary infiltration anesthesia using Transcodent painless needle tips and conventional dental needle tips.
- Trial name
- NCT07703410
- Testing
- Transcodent Painless Needle Tip, Conventional Dental Needle Tip
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saidu College of Dentistry
Osteo Arthritis of the Knee
Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty
The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral…
- Trial name
- BALIA (NCT07350252)
- Testing
- Ropivacain 5 mg/ml + Clonidine
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Chronic Pain
Clinical Trial to Evaluate the Efficacy and Safety of Platelet-rich Plasma Infiltration in Chronic Omalgia
The experimental group will receive intralesional injections of platelet-rich plasma, evaluating its ability to relieve pain and provide sustained improvement through biological modulation of the joint and tendon environment.
- Trial name
- NCT07448285
- Testing
- Platelet-rich Plasma Local injection, betamethasone and Ropivacaine
- Where
- 2 sites in Spain
- Volunteers
- 86 people
- Sponsor
- Biobizkaia Health Research Institute