Clinical trials: Localized Cancer, open to volunteers
Cancer, Psychological Distress
Feasibility and Efficacy of the EMDR Toolbox Method in Cancer Patients.
The incidence of adverse childhood experiences (ACEs) is significantly elevated in patients affected by organic diseases (Riedl, 2020).
- Trial name
- NCT07481890
- Testing
- STANDARD EMDR, EMDR TOOLBOX METHOD
- Where
- 2 sites in Switzerland
- Volunteers
- 46 people
- Sponsor
- Lega Cancro Ticino
Localized Prostate Adenocarcinoma
Feasibility of MR-Informed Adaptive Marker-less SBRT in Patients With Bilateral Hip Prostheses Undergoing SBRT for Localized Prostate Cancer
Hip replacements and prostate cancer are independently and both together increasing prevalent in the aging population. In the United States, the prevalence of hip prostheses among men was 1.1 million in 20101, with approximately…
- Trial name
- HIP-PRO (NCT07042256)
- Testing
- Low-field MR-informed adaptive marker-less SBRT for definitive treatment of localized prostate cancer in patients with bilateral hip prostheses
- Where
- Switzerland
- Volunteers
- 13 people
- Sponsor
- University of Zurich
Prostate Adenocarcinoma, Prostate Cancer
Utilization of Flotufolastat 18F PET for Post-Focal Therapy Prostate Cancer Evaluation
This is a phase II single arm, open-label clinical trial determining diagnostic accuracy of Flotufolastat F18 PET in subjects with prostate adenocarcinoma.
- Trial name
- NCT07568756
- Testing
- Flotufolastat F18 PET
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Irvine
Hepatocellular Carcinoma
Radioembolization as a Spearhead Treatment of Hepatocellular Carcinoma With Localized Portal Vein Tumor Thrombosis
The RESOLVE trial, an open-label, single-arm, multi-center study, aims to assess the efficacy and safety of ablative radioembolization using TheraSphere Yttrium-90 microspheres.
- Trial name
- RESOLVE (NCT06166576)
- Testing
- Ablative radioembolization
- Where
- 5 sites in South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Postmastectomy Lymphedema Syndrome, Breast Cancer Surgery Pain
Deep Learning for Musculoskeletal Complications in Breast Cancer
Survival after breast cancer has increased due to early diagnosis and advances in treatment methods. Musculoskeletal problems related to cancer and its treatment constitute a significant part of the daily practice of physiatrists…
- Conditions
- Postmastectomy Lymphedema Syndrome, Breast Cancer Surgery Pain, Osteoporosis Secondary, Shoulder Adhesive Capsulitis
- Trial name
- NCT07236658
- Testing
- physical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 133 people
- Sponsor
- Ankara Etlik City Hospital
Localized Clear Cell Renal Cell Carcinoma, Resectable Clear Cell Renal Cell Carcinoma
Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell Cancer
This phase II trial studies how well ivonescimab works prior to surgery in treating patients with high-risk clear cell kidney (renal cell) cancer that has not spread to other parts of the body (localized).
- Conditions
- Localized Clear Cell Renal Cell Carcinoma, Resectable Clear Cell Renal Cell Carcinoma, Stage II Renal Cell Cancer AJCC v8, Stage III Renal Cell Cancer AJCC v8
- Trial name
- NCT07226544
- Testing
- Biopsy Procedure, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- City of Hope Medical Center
Colon Cancer, Colon Adenocarcinoma
Improving Prognostication in Colon Cancer
The goal of this study is to test better ways to predict if cancer will return after surgery in adults (18+) who have been diagnosed with stage II or III colon cancer.
- Trial name
- MARBLE (NCT07673393)
- Testing
- Blood draw for the laboratory assessment
- Volunteers
- 400 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Small Cell Neuroendocrine Carcinoma of Bladder, Bladder Cancer
Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer
This is a single arm, Phase II trial involving the use of atezolizumab plus platinum and etoposide for patients with locally advanced urothelial cancer.
- Conditions
- Small Cell Neuroendocrine Carcinoma of Bladder, Bladder Cancer, Urothelial Carcinoma Bladder
- Trial name
- NCT05312671
- Testing
- Atezolizumab, Carboplatin, Cisplatin
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer (Diagnosis), Prostatic Neoplasms
Real-time Fluorescence Microscopy for Intraoperative Assessment of Prostate Biopsy Cores (FLASH)
Current prostate cancer diagnosis relies on MRI-targeted biopsy combined with a 12-core systematic biopsy. The systematic component is a major driver of overdiagnosis of insignificant cancer and biopsy-related morbidity, and…
- Trial name
- FLASH (NCT07846592)
- Testing
- Ex vivo real-time fluorescence microscopy of prostate biopsy cores (EndoScell system, model MES-1000P)
- Volunteers
- 450 people
- Sponsor
- Shanghai East Hospital
Prostate Cancer, Prostate Adenoma
Efficacy and Safety of Radical Prostatectomy (RP) With or Without Salvage Radiotherapy Versus RP With Extended Pelvic Lymph Node Dissection for Localized Intermediate- and High-risk Prostate Cancer With a Briganti Nomogram≥7%
The goal of this clinical trial is to evaluate efficacy and safety of radical prostatectomy (RP) with or without salvage radiotherapy versus RP with extended pelvic lymph node dissection (ePLND) in males who have localized…
- Trial name
- PRESEL (NCT07115992)
- Testing
- RARP±SRT, RARP+ePLND
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Ruijin Hospital
Pancreatic Cancer
Pancreatic Cancer Adaptive Neoadjuvant Chemotherapy Trial
This is an open-label, phase II study in patients with resectable and borderline resectable pancreas cancer.
- Trial name
- PANC (NCT03322995)
- Testing
- First-line Chemotherapy, Second-line Chemotherapy, Chemoradiation
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Medical College of Wisconsin
Prostate Cancer, Biochemical Recurrence
Predictors of BCR After RARP for Localized Prostate Cancer: A Retrospective Analysis
This retrospective study aims to identify predictive factors for biochemical recurrence (BCR) in patients with localized prostate cancer who underwent robot-assisted radical prostatectomy (RARP).
- Trial name
- NCT07682584
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Prostate Cancer
Adaptive Versus Non-adaptive Radiotherapy and 2 Bladder Filling Instructions for Patients With Intermediate or High Risk Localized Prostate Cancer (ARP)
The study is being done to compare the side effects between two different radiation techniques, standard non-adaptive radiation therapy vs.
- Trial name
- NCT06678126
- Testing
- Prostate and Pelvic Nodes Radiotherapy
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Scott Tyldesley
Localized Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma
Neoadjuvant Triple Therapy for (Borderline) Resectable Pancreatic Cancer (PREOPANC-5)
Since patients with (borderline) resectable pancreatic cancer have a limited life expectancy, it is important to improve treatment strategies.
- Conditions
- Localized Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma, Resectable Pancreatic Adenocarcinoma
- Trial name
- PREOPANC-5 (NCT06384560)
- Testing
- Pembrolizumab, Folfirinox, SABR
- Where
- 4 sites in Netherlands
- Volunteers
- 66 people
- Sponsor
- Amsterdam UMC, location VUmc
Prostate Cancer
Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance
This is a prospective study to determine if the use of curcumin randomized against placebo will reduce cancer progression in patients with prostate cancer undergoing active surveillance.
- Trial name
- NCT03769766
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of Texas Southwestern Medical Center
Prostate Cancer
HIFU for Focal Ablation of Prostate Tissue: An Observational Study
The Sonablate HIFU device was approved by the U.S.FDA for prostate tissue ablation in October, 2015. The purpose of this observational research study is to investigate the localized treatment of prostate cancer using HIFU through…
- Trial name
- NCT03620786
- Testing
- Sonablate HIFU device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Prostate Cancer
Understanding of Genetics by Men at Risk for Prostate Cancer
With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions.
- Trial name
- NCT04550845
- Testing
- Focus group analyses
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prostate Cancer
Circulating Tumor DNA in High Risk Localized Prostate Cancer
This prospective, non-therapeutic translational biomarker study will collect blood in patients with high risk localized prostate cancer prior to prostatectomy.
- Trial name
- NCT07222436
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Pittsburgh
Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8
Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer
This phase II trial tests how well immunotherapy (toripalimab) works for reducing the risk of cancer recurrence after surgery in patients with mismatch repair deficient stage IIB, IIC, or III colon cancer.
- Conditions
- Localized Colon Carcinoma, Stage IIB Colon Cancer AJCC v8, Stage IIC Colon Cancer AJCC v8, Stage III Colon Cancer AJCC v8
- Trial name
- NCT07140679
- Testing
- Biopsy Procedure, Biospecimen Collection, Colonoscopy
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Kidney Neoplasm
Clinical Trial Addressing the Best Surgical Approach for Partial Nephrectomy With Single Port Robotic System in the Management of Localized Renal Cell Carcinoma
This study aims to find out which surgical position is safer and works better for patients candidate to robot-assisted partial nephrectomy (RAPN) - a minimally invasive procedure to remove a small kidney tumor while preserving…
- Trial name
- K3 (NCT07234409)
- Testing
- STANDARD FLANK APPROACH, Supine anterior retroperitoneal approach (SARA).
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- Niguarda Hospital