Clinical trials: Localized Prostate Cancer
Localized Prostate Cancer
Prospective Clinical Safety and Efficacy Study of Lesion-targeted MRI-TULSA for Localized Prostate Cancer
Magnetic resonance imaging (MRI) has improved detection of clinically significant prostate cancer (PCa). MRI-guided transurethral ultrasound ablation (MRI-TULSA) system incorporates precise diagnosis and simultaneous ablation of…
- Trial name
- PRO-TULSA-PC (NCT03814252)
- Testing
- MRI-TULSA
- Where
- Finland
- Volunteers
- 62 people
- Sponsor
- Turku University Hospital
Prostate Cancer, Radiotherapy Side Effect
Ultra Hypofractionnated Radiotherapy With HDR Brachytherapy Boost.
Phase 1-2 study, comparing ultra-hypofractionnated (UH) to a moderately hypofractionnated (MH) radiation therapy, with image guided HDR prostate brachytherapy.
- Conditions
- Prostate Cancer, Radiotherapy Side Effect, Hypofractionation, Brachytherapy
- Trial name
- HYPO-5 (NCT05786742)
- Testing
- grade and compare reported side effects between groups
- Where
- Canada
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Erectile Dysfunction, Localized Prostate Carcinoma
LiSWT for Nerve Sparing Radical Prostatectomy ED
This phase I clinical trial studies how well low intensity shockwave therapy (LiSWT) improves erectile function in patients who have had nerve-sparing radical prostatectomy (NS-RP), a type of surgery that attempts to save the…
- Conditions
- Erectile Dysfunction, Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
- Trial name
- NCT05877144
- Testing
- Nerve-Sparing Prostatectomy, Medical Device Usage and Evaluation, Duplex Ultrasound
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Thomas Jefferson University
Localized Prostate Cancer, Active Surveillance for Prostate Cancer
Active Surveillance Exercise Clinical Trial
This phase 2, open-label, dual-center, two-arm randomized controlled trial (RCT) investigates the effects of 16 weeks of structured aerobic training, relative to usual care (print material with physical activity guidance).
- Trial name
- ASX (NCT02435472)
- Testing
- Exercise, Cardiopulmonary Exercise Test (CPET)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of California, San Francisco
Localized Intermediate Risk Prostate Lesions
Focal MR-Guided Focused Ultrasound Treatment of Localized Intermediate Risk Prostate Lesions
The hypothesis of this study is that focal treatment with ExAblate MRgFUS has the potential to be an effective non-invasive treatment for intermediate risk, organ-confined prostate lesions, with a low incidence of morbidity.
- Trial name
- NCT01657942
- Testing
- ExAblate MR Guided Focused Ultrasound
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- InSightec
Biochemically Recurrent Prostate Carcinoma, Localized Prostate Carcinoma
An Investigational Scan (rh PSMA 7.3 PET/MRI) for the Detection of Recurrent Disease and Aid in Radiotherapy Planning in Biochemically Recurrent Prostate Cancer
This prospective pilot study will assess the feasibility of rh PSMA 7.3 positron emission tomography/magnetic resonance imaging (PET/MRI) scans in detecting prostate cancer that may have come back (recurrent) in patients with…
- Conditions
- Biochemically Recurrent Prostate Carcinoma, Localized Prostate Carcinoma, Prostate Adenocarcinoma
- Trial name
- NCT04978675
- Testing
- Fluorine F 18 rhPSMA-7.3, Magnetic Resonance Imaging, Positron Emission Tomography
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Localized Prostate Cancer
Radical Hypofractionated Radiotherapy for Localized Prostate Cancer
The aim of this trial is to study the safety outcomes of hypofractionated radiotherapy in treating patients with localized prostate cancer.
- Trial name
- NCT06325774
- Testing
- Hypofractionated radiation therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Changhai Hospital
Localized Prostate Cancer
Hypofractionated Post-prostatectomy Radiotherapy (HYPORT)for Localized Prostate Cancer
The aim of this trial is to compare the safety outcomes of Hypofractionated postprostatectomy radiotherapy (HYPORT) and Conventionally fractionated postprostatectomy radiotherapy(COPORT) in treating patients with localized…
- Trial name
- NCT06325995
- Testing
- Conventional radiation therapy, Hypofractionated radiation therapy
- Where
- China
- Volunteers
- 428 people
- Sponsor
- Changhai Hospital
Localized Prostate Cancer
Clinical Study of HIFU for Localized Prostate Cancer
In this study, the safety and effectiveness data of Sonablate system, a transrectal high-intensity focused ultrasound therapeutic instrument, in the treatment of localized prostate cancer were collected, and the treatment…
- Trial name
- HIFU (NCT06362577)
- Testing
- EQ-5D-5L IPSS IIEF-5 EPIC-26 ECOG
- Where
- China
- Volunteers
- 60 people
- Sponsor
- RenJi Hospital
Localized Prostate Cancer
PRCT002 PRostate Cancer Treatment With the AQUABEAM Robotic System
The goal of this clinical trial is to evaluate the safety of the AQUABEAM Robotic System in treating patients with localized prostate cancer. Participants will go through baseline and follow up assessments up to 12 months.
- Trial name
- NCT06054867
- Testing
- Robotic Waterjet Treatment
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- PROCEPT BioRobotics
High Risk Localized Prostate Cancer
A Study of High Risk Localized Prostate Cancer Participants Treated With Radical Prostatectomy and Perioperative Hormonal Therapy
The purpose of this study is to evaluate the yearly conditional prostate-specific antigen (PSA) progression-free survival (PFS) probabilities in high-risk localized prostate cancer (HR LPC) participants following radical…
- Trial name
- ACE (NCT05303558)
- Where
- 9 sites in Japan, South Korea and 1 more
- Volunteers
- 221 people
- Sponsor
- Johnson & Johnson International (Singapore) Pte. Ltd.
Prostate Cancer, Prostate Adenocarcinoma
Two-Fraction Ultrahypofractionated Radiotherapy With Focal Boost for Intermediate Risk, Localized Prostate Cancer
The goal of this clinical trial is to assess the non-inferiority irradiating low and intermediate risk, localized prostate cancer in two fractions of radiotherapy, compared to five fractions of radiotherapy which is the standard…
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Localized Prostate Carcinoma
- Trial name
- TURBO (NCT06518226)
- Testing
- Ultrahypofractionated MRgRT in 2 fractions, Standard of care: MRgRT in 5 fractions
- Where
- Netherlands
- Volunteers
- 160 people
- Sponsor
- UMC Utrecht
Prostate Cancer, Localized Carcinoma
Validation of the Stockholm3 Test for Detection of Prostate Cancer in the Swiss Population
The purpose of this study is to collect blood samples to investigate the prognostic performance of the STHLM3 test in a population of Swiss and German men suspected of harbouring prostate cancer based on a combination of elevated…
- Trial name
- NCT05294627
- Testing
- Stockholm3
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University Hospital, Basel, Switzerland
Predictive Cancer Model, Localized Prostate Carcinoma
Generation and Validation of Predictive Models for Localized Prostate Cancer Treated With External Radiotherapy.
The generation of predictive models in radiotherapy has seen a significant increase. In 2017, Raymond published the largest systematic review of predictive prognostic models for biochemical relapse (BR), metastasis-free survival…
- Trial name
- NCT06092918
- Testing
- EXTERNAL RADIOTHERAPY
- Volunteers
- 700 people
- Sponsor
- Consorci Sanitari de Terrassa
Localized or Locally Advanced Prostate Cancer
A Multi-centre, Prospective, Observational Study on Effectiveness and Safety of ZOLADEX® (Goserelin Acetate Implant) 10.8 mg and ZOLADEX® (Goserelin Acetate Implant) 3.6 mg in Chinese Patients With Localized or Locally Advanced Hormonal Treatment -naïve Prostate Cancer
This study is a multi-centre, prospective observational study. The study plans to enrol 500 patients with localized or locally advanced prostate cancer who are eligible and intended to be prescribed Zoladex® (goserelin acetate…
- Trial name
- NCT03193060
- Where
- 25 sites in China
- Volunteers
- 308 people
- Sponsor
- AstraZeneca
Prostate Cancer, Localized Malignant Neoplasm
Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery
Quality of life data following SBRT for prostate cancer has been obtained in only a small numbers of patients. A prospective study using validated quality of life questionnaires is needed to determine outcomes after treatment…
- Trial name
- PR-PROS (NCT01766492)
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Georgetown University
Prostate Cancer, Prostate Adenocarcinoma
Trial of NanoPac Focal Therapy for Prostate Cancer
This study evaluates the use of NanoPac injected directly into the prostate lesion in men with prostate cancer.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Adenocarcinoma, Prostatic Neoplasm
- Trial name
- NCT04221828
- Testing
- NanoPac (sterile nanoparticulate paclitaxel) Powder for Suspension
- Where
- 4 sites in United States
- Volunteers
- 1 people
- Sponsor
- NanOlogy, LLC
Localized Prostate Cancer
Functional Image-Guided Carbon Ion Irradiation With Simultaneous Integrated Boost for Prostate Cancer
This is a phase II randomized controlled clinical trial to assess the toxicities and clinical efficacy of prostate specific membrane antigen (PSMA) positron emission tomography / computed tomography (PET/CT) and multi- parameter…
- Trial name
- NCT05010343
- Testing
- carbon ion irradation, Carbon Ion Irradiation With SIB
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Localized Prostate Cancer
Evaluation of Efficacy of TOOKAD® (VTP) Versus Active Surveillance for Intermediate Risk Localized Prostate Cancer
Multi-center, prospective, randomized controlled clinical trial that will compare two treatment methods (PGA with TOOKAD® VTP and Active Surveillance) for treating localized prostate cancer.
- Trial name
- NCT04225299
- Testing
- TOOKAD®
- Where
- United States
- Sponsor
- Steba Biotech S.A.
Localized Prostate Cancer
Use of Recombinant Adenovirus Therapy to Treat Localized Prostate Cancer
The purpose of this study is to evaluate the safety and effectiveness of AD5-SGE-REIC/Dkk-3 in patients with localized prostate cancer.
- Trial name
- NCT01931046
- Testing
- Ad5-SGE-REIC/Dkk3
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Momotaro-Gene Inc.