Clinical trials: Locally Advanced Perihilar Cholangiocarcinoma
Treatment Response, Adverse Events
Photodynamic Therapy in Locally Advanced Hilar Cholangiocarcinoma
To determine the safety and efficacy of photodynamic therapy with a novel photosensitizer and a flexible laser probe in locally advanced hilar cholangiocarcinoma.
- Conditions
- Treatment Response, Adverse Events, Feasibility
- Trial name
- PDT (NCT02725073)
- Testing
- Photodynamic therapy
- Where
- 2 sites in South Korea
- Volunteers
- 32 people
- Sponsor
- Asan Medical Center
Cholangiocarcinoma Non-resectable
Preoperative Right Hepatic Artery Embolization for Locally Advanced Bismuth IIIb and IV Perihilar Cholangiocarcinoma
This is a prospective, multicenter, single-arm study investigating the efficacy and safety of preoperative right hepatic artery embolization (PHAE) followed by surgical resection in patients with locally advanced Bismuth IIIb or…
- Trial name
- PHAE-PHCC (NCT07326189)
- Testing
- Preoperative Right Hepatic Artery Embolization
- Volunteers
- 33 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Locally Advanced Perihilar Cholangiocarcinoma
A Prospective, Single-Arm, Phase II Study: PD-L1 Monoclonal Antibody + Chemoradiotherapy as Bridge Therapy to Liver Transplantation for Locally Advanced Perihilar Cholangiocarcinoma (ACHIEVE-LT)
This study is a prospective, single-arm, phase II clinical trial designed to evaluate the safety and efficacy of PD-L1 monoclonal antibody combined with chemoradiotherapy as a bridge to liver transplantation in patients with…
- Trial name
- ACHIEVE-LT (NCT07471165)
- Testing
- PD -1/PD-L1 monoclonal antibody plus radiotherapy and liver transplantation
- Where
- 2 sites in China
- Volunteers
- 25 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Extrahepatic Bile Duct Adenocarcinoma, Gallbladder Adenocarcinoma
Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma
This phase II trial is studying how well giving sorafenib tosylate together with erlotinib hydrochloride works in treating patients with locally advanced, unresectable, or metastatic gallbladder cancer or cholangiocarcinoma.
- Conditions
- Extrahepatic Bile Duct Adenocarcinoma, Gallbladder Adenocarcinoma, Gallbladder Adenocarcinoma With Squamous Metaplasia, Hilar Cholangiocarcinoma
- Trial name
- NCT01093222
- Testing
- Erlotinib Hydrochloride, Sorafenib Tosylate
- Where
- 141 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Perihilar Cholangiocarcinoma
Biliary Drainage Plus HAIC in Locally Advanced pCCA
Biliary drainage and stent placement remains to be the main palliative treatment choice for advanced perihiliar cholangiocarcinoma (pCCA), and the life expectancy is only 4-6 months.
- Trial name
- NCT05024513
- Testing
- oxaliplatin and 5-fluorouracil, Biliary Drainage, Best Supportive Care
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Peking University
Cholangiocarcinoma
Regorafenib Versus Placebo to Treat Cholangiocarcinoma
The study is a multicenter randomized (1:1) placebo-controlled, double-blinded phase II trial aiming to demonstrate an improvement of median PFS when treating locally advanced unresectable or metastatic patients suffering from an…
- Trial name
- REACHIN (NCT02162914)
- Testing
- Regorafenib/active
- Where
- 12 sites in Belgium
- Volunteers
- 66 people
- Sponsor
- Erasme University Hospital
Locally Advanced Cholangiocarcinoma, Metastatic Cholangiocarcinoma
Sacituzumab Govitecan for the Treatment for Patients With Locally Advanced, Recurrent, or Metastatic Cholangiocarcinoma
This phase II trial tests how well sacituzumab govitecan works in treating patients with cholangiocarcinoma that has spread to nearby tissue or lymph nodes (locally advanced), that has come back after a period of improvement…
- Conditions
- Locally Advanced Cholangiocarcinoma, Metastatic Cholangiocarcinoma, Recurrent Cholangiocarcinoma, Stage III Hilar Cholangiocarcinoma AJCC v8
- Trial name
- NCT06178588
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Kansas Medical Center
IRE
HCCANANO-HOPE1: IRE After Chemotherapy for Locally Advanced Unresectable Perihilar Cholangiocarcinoma
Irreversible electroporation is a non-thermal ablative technology that uses high-voltage electric pulses to create permanent nanopores in tumor cell membranes, leading to apoptosis or other forms of cell death.
- Trial name
- NCT07795619
- Testing
- IRE+chemotherapy, chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital