Clinical trials: Locomotor Activity
Spinal Cord Injury
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to…
- Trial name
- NCT07223710
- Testing
- Paired Associative Stimulation, Locomotor Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Spatial Perception, Stroke
Effect of Lower Limb Exproprioception Training in Virtual Environment on Locomotion Performance in Stroke Patients
The purpose of this study is to determine if a virtual reality training of foot placement with or without visual cues about the location of the foot in the environment would improve locomotion-related function in persons in the…
- Conditions
- Spatial Perception, Stroke, Virtual Reality, Exercise Training
- Trial name
- NCT04436237
- Testing
- Virtual reality foot placement training
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng Kung University
Parkinson Disease
Effect of L-Dihydoxyphenylserine on Locomotion, Postural Stability, and Fall Risk Reduction in Parkinson Disease
This research study is being done to determine whether treatment with L- Dihydroxyphenylserine (L-DOPS) versus placebo (an inactive substance that looks like study drug) in addition to other Parkinson Disease (PD) drugs will…
- Trial name
- NCT02812147
- Testing
- L-DOPS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Postural Balance
Evaluation of Foot Mechanical Information on Static Task and Locomotion
Sensory foot integration is evaluated by foam under feet both in research and clinical contexts. However, there is no norm defined regarding foam characteristics and this evaluation is mostly performed using a static task.
- Trial name
- NCT05170750
- Testing
- Foams, Foam / Orthopedic insole
- Where
- 2 sites in France
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Rennes 2
Young Children With Motor Disabilities
Using Head-mounted, Eye-tracking to Compare Looking, Manual Exploration and Social Interaction During Active Locomotion
The three purposes of this study are: 1) to determine the feasibility of using a head-mounted eye-tracker and examine the effects of the optimal mobility training on increasing visual and manual exploration in toddlers with…
- Trial name
- NCT05441137
- Testing
- Ride-On Cars Training with Different Postures, Conventional Therapy
- Where
- 2 sites in Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
COVID-19
LOng COvid Multidisciplinary Consortium: Optimising Treatments and servIces Across the NHS (LOCOMOTION)
Background: Long Covid (LC) affects over one million people in the UK, it has various symptoms and impacts daily life. Although there are 83 LC clinics in England, most people have not had access to them, and waiting times to be…
- Trial name
- LOCOMOTION (NCT05057260)
- Testing
- No drug invervention
- Where
- United Kingdom
- Volunteers
- 7,000 people
- Sponsor
- University of Leeds
Stroke
Virtual Reality and Field Training to Enhance Community Walking After Stroke
While stroke survivors discharged from rehabilitation present with some recovery in mobility, their ability to ambulate in the community remains limited.
- Trial name
- NCT04559373
- Testing
- Virtual Reality and Field Training (VRFT)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McGill University
Multiple Sclerosis
The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis
Majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls.
- Trial name
- NCT05878873
- Testing
- Split-belt Treadmill, Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Multiple Sclerosis
Biomechanical Characterization of the Locomotion in Multiple Sclerosis Patients
Multiple sclerosis (MS) is an inflammatory chronic disease of the central nervous system. Patients are suffering from balance and gait impairments at the early stage of the disease.
- Trial name
- WALKING-SEP (NCT03756142)
- Testing
- Motion Analysis
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Healthy
Nerve Stimulation to Modify a Spinal Reflex
This study will determine whether stimulating the nerves or the brain can modify the spinal reflex that controls the muscles that flex and extend the ankle.
- Trial name
- NCT00039819
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Flatfoot
The Influence of Rehabilitation Program on Postural Control, Balance and Gait in Children With Flatfoot
"Idiopathic flat foot is a common condition in children and adolescents. After loading, the heel is adjusted in valgus, the medial longitudinal arch of the foot flattens, and the forefoot is positioned at abducted.
- Trial name
- NCT04840017
- Testing
- rehabilitation exercise
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Stroke
Locomotor Experience Applied Post Stroke Trial
The purpose of this study is to compare two different treatments to improve walking after stroke (or post-stroke).
- Trial name
- LEAPS (NCT00243919)
- Testing
- Early locomotor training program, Late locomotor training program, Home Exercise Program
- Where
- 8 sites in United States
- Volunteers
- 408 people
- Sponsor
- Duke University
Healthy Volunteers
Global Positioning Satellite and Accelerometry to Assess Human Locomotion (ACTI GPS)
The aim of the study is to validate the association of the GPS and accelerometer tools in order to assess the humain locomotion during exercises. The hypotheses are: 1.
- Trial name
- ActiGPS (NCT01805219)
- Testing
- GPS and accelerometer recording (s) during exercises
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Stroke
HIT-Stroke Trial 2
People who had a stroke at least 6 months prior and who still have difficulty with walking will each be randomly assigned to receive either moderate or vigorous intensity walking exercise.
- Trial name
- HST2 (NCT06268041)
- Testing
- Moderate-Intensity Aerobic Training, High-Intensity Interval Training
- Where
- 3 sites in United States
- Volunteers
- 156 people
- Sponsor
- University of Cincinnati
Gait Training, Locomotion
Gait Training and Brain Changes in Stroke Patients
This study, conducted in collaboration with the National Rehabilitation Hospital (NRH) in Washington, D.C., will look at changes in brain activation and brain responses that occur with gait (walking) training.
- Trial name
- NCT00334230
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Movement Disorders, Parkinson Disease
STEPWISE Parkinson: A Smartphone Based Exercise Solution for Patients With Parkinson's Disease
The aim of this study is to investigate whether a smartphone app can increase physical activity in patients with Parkinson's Disease in daily life for a long period of time (12 months).
- Trial name
- STEPWISE (NCT04848077)
- Testing
- Step count increase with the use of a motivational smartphone application
- Where
- Netherlands
- Volunteers
- 452 people
- Sponsor
- Radboud University Medical Center
Incomplete Spinal Cord Injury
Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
Spinal cord injury (SCI) affects ~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility.
- Trial name
- AGILE SCI (NCT04340063)
- Testing
- Gait training performed on a treadmill, Gait training performed in a Movement Amplification Environment
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- VA Office of Research and Development
Stroke, Hemiparetic Patients After Subacute Stroke
Effects of Locomotion Training With Assistance of a Robot-Driven Gait Orthosis in Hemiparetic Patients After Subacute Stroke
The investigators aimed in this study to investigate the effects of 4 weeks robot-assisted locomotor training on motor recovery of lower extremities and walking ability compared with the conventional gait training in subacute…
- Trial name
- NCT01726998
- Testing
- Robot-assisted gait therapy, conventional gait training
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Child Development
Dual Tasking in Children With Cerebral Palsy and Healthy Children: an EEG Study
Simultaneous execution of motor and cognitive tasks is embedded in the daily life of children. An EEG study will be conducted on healthy children and children with cerebral palsy to study the neural correlates during dual tasking…
- Trial name
- PRALOC (NCT04634292)
- Testing
- EEG
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Rehabilitation, Parkinson Disease
Golden Walk as Measure of Gait Rehabilitation in Parkinson's Disease
Gait is specifically impaired in Parkinson's disease (PD). External auditory cue based on a binary rhythm tested in PD patients disappear when the stimulus is removed.
- Conditions
- Rehabilitation, Parkinson Disease, Locomotion Disorder, Neurologic, Rhythm; Abnormal
- Trial name
- NCT04706572
- Testing
- Stimulation with external auditory bio-feedback
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia