Clinical trials: Locoregional Anaesthesia
Local Anesthesia
Effects of Articaine Computer-controlled and Conventional Delivery for Anterior and Middle Superior Alveolar Nerve Block
The purpose of this study was to investigate and compare pulpal anesthesia and cardiovascular parameters obtained with 0.6 ml of 4% articaine with epinephrine (1:100.000) for anterior and middle superior alveolar nerve (AMSA)…
- Trial name
- NCT02440347
- Testing
- Computer controlled anesthetic delivery by Anaeject, Conventional anesthetic delivery by carpule syringe
- Where
- Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Dental Anxiety, Pain Management
Impact of Local Anesthesia Techniques on Children's Dental Treatment Experience
compare the effectiveness of several local anesthetic delivery systems in managing pain, anxiety, behavior, and vital signs among pediatric dental patients.
- Conditions
- Dental Anxiety, Pain Management, Pediatric Dentistry
- Trial name
- NCT07106138
- Testing
- Conventional syringe injection, Star Pen, Comfort-In
- Where
- Syria
- Volunteers
- 112 people
- Sponsor
- Latakia University
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery
Opioid overuse is a widespread public health crisis in the United States with increasing rates of addiction and overdose deaths from prescription opioids.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Spondylolisthesis, Lumbar Spondylosis
- Trial name
- NCT05029726
- Testing
- Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- John O'Toole
Lidocaine, Bupivacaine
Comparing the Efficacy of Local Anesthetics in Mohs Surgery
Mohs surgery is a very effective option in removing non-melanoma skin cancers, as the tissue being removed is analyzed the same day.
- Conditions
- Lidocaine, Bupivacaine, Mohs Surgery, Anesthetic
- Trial name
- NCT03871478
- Testing
- Lidocaine, Bupivacaine, Lidocaine and Bupivacaine
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Ottawa Hospital Research Institute
Postoperative Nausea and Vomiting (PONV), Subarachnoid Block
Comparison of Haloperidol and Ondansetron in Reducing Postoperative Nausea and Vomiting in RA-SAB Patients
This study aims to evaluate and compare the effectiveness of intravenous haloperidol and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery with subarachnoid block (spinal…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Subarachnoid Block, Spinal Anesthesia
- Trial name
- HALO-PONV (NCT07087925)
- Testing
- Haloperidol, Ondansetron 4mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Rully Riyandika
Cerebral Ischemia-Hypoxia
Effect of Sedatives on Regional Cerebral Oxygen Saturation
Compare the changes of regional cerebral oxygen saturation during midazolam or dexmedetomidine sedation for spinal anesthesia in the elderly patients who undergoing femur surgery.
- Trial name
- 2 (NCT02966743)
- Testing
- Midazolam, Dexmedetomidine
- Where
- South Korea
- Sponsor
- Gachon University Gil Medical Center
Postoperative Pain
Transversus Abdominis Plane Blocks for Infants and Children for Postoperative Pain Control
After undergoing hernia surgery, hydrocelectomy or lower abdominal surgery, a child may experience some amount of pain in the post-operative period.
- Trial name
- NCT01559740
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).
- Conditions
- Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Global Cardiac Wall Motion Dysfunction
- Trial name
- NCT05650008
- Testing
- Intrathecal local anesthesia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Pain, Postoperative
Effectiveness of Adductor Canal Block Using Liposomal Bupivacaine
With aging of population, osteoarthritis of knees and hips become major orthopaedic problems in Hong Kong. Osteoarthritis of knees and hips are associated with significant pain problem and functional disability.
- Trial name
- NCT04003506
- Testing
- Liposomal bupivacaine, Bupivacaine Injection
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Analgesics, Opioid, Anesthetics, Local
Opioid Use of Local Anaesthetic Agents in Open Heart Surgery and Its Effect on Recovery
The aim of this randomized controlled study was to investigate the effect of injecting local anesthetic agents into the sternotomy incision site and around the drains on the amount of opioids used in the postoperative period and…
- Trial name
- NCT06642077
- Testing
- LIDOFAST 40 mg/2 ml + 0.025 mg/2 ml
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Yuzuncu Yil University
Anxiety, Fear
AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia
This randomized clinical trial aims to compare two behavior guidance techniques used to reduce anxiety in children during local anesthesia injections in dental treatment.
- Conditions
- Anxiety, Fear, Local Anesthesia, Pediatric Dentistry
- Trial name
- NCT07449884
- Testing
- AI Avatar-Based video, Tell-Show-Do Technique
- Where
- Lebanon
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Postoperative Pain, Hernia, Inguinal
Comparison Of Ultrasound Guided Transversus Abdominis Plane Block Versus Wound Infiltration With Local Anesthetics for Post Operative Analgesia
This randomized controlled trial compared two methods of pain relief after inguinal hernia repair: an ultrasound-guided transversus abdominis plane (TAP) block and local anesthetic injection around the surgical wound.
- Trial name
- NCT07913633
- Testing
- Ultrasound-Guided Transversus Abdominis Plane Block, Local Anesthetic Wound Infiltration, Bupivacaine
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Mayo Hospital Lahore
ERAS
Effect of Regional Anesthesia on Enhanced Recovery After Spine Surgeries
This study will be carried out on 80 patients who will be presented for different spine surgeries under general anesthesia and regional anesthesia technique in Tanta university hospitals.
- Trial name
- NCT04586257
- Testing
- Erector spinae plane block, Throacolumbar interfacial plane block
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Tanta University
Regional Anesthesia Morbidity, Postoperative Pain
Local Anesthesia Spread After an Erector Spinae Plane Block.
This a single-center prospective spread-evaluation study where the primary objective is to assess the spread of local anesthesia in an ESPB using magnetic resonance imaging (MRI).
- Trial name
- NCT05012332
- Testing
- Erector Spinae Plane Block
- Where
- Norway
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Pain in Pediatric Dentistry, Dental Anxiety
Effectiveness of Digital Anesthesia Versus Conventional Techniques in Reducing Pain and Anxiety in Children
This multicenter randomized controlled clinical trial was conducted to evaluate the effectiveness of digital anesthesia using a computer-controlled intraosseous system (SleeperOne 5®) compared to traditional local anesthesia…
- Trial name
- DAPAED (NCT06992193)
- Testing
- Digital Anesthesia, Infiltration Anesthesia, Mandibular Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Ege University
Anesthetics, Local
Split Face Study of the Duration of Local Anesthetics
This is a research study to compare how long injectable pain medications (anesthetics) commonly used in dermatologic surgery are effective for.
- Trial name
- NCT05767749
- Testing
- lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Low-level-laser Theraphy, Anesthesia, Local
Anethesia Efficacy on Teeth With MIH (Molar Incisor Hypomineralisation)
Difficulty in achieving anesthesia in teeth with molar incisor hypomineralisation (MIH) is a frequently reported clinical problem.
- Conditions
- Low-level-laser Theraphy, Anesthesia, Local, Molar Incisor Hypomineralization
- Trial name
- MIH (NCT05344014)
- Testing
- Photobiomodulation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Administration, Topical Drug, Administration, Topical
Topical Formulations of Liposomal Local Anesthetics
This blinded cross-over study aim to evaluate the efficacy of topical liposome-encapsulated ropivacaine formulations.
- Conditions
- Administration, Topical Drug, Administration, Topical, Anesthetic Drugs
- Trial name
- NCT01054547
- Testing
- Ropivacaine
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Postoperative Pain
Single Dose Pharmacokinetics and Pharmacodynamics of Bupivacaine Following Transversus Abdominis Plane (TAP) Block in Neonates
This study is being done to try to learn more about how a child's body breaks down bupivacaine, a local anesthetic medication that is being used for pain control.
- Trial name
- NCT01557985
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Lumbar Disc Herniation
Lumbar Epidural Analgesia Versus Local Anesthesia With Dexmedetomidine Infusion in Endoscopic Lumbar Discectomy
To compare between local anesthesia combined with intravenous Dexmedetomidine and epidural analgesia as regard the effectiveness and patient satisfaction during percutaneous transforaminal endoscopic discectomy.
- Trial name
- NCT05850455
- Testing
- Dexmedetomidine Hydrochloride 'Precedex' combined with, Lumbar epidural analgesia with Bupivacaine 0.25% 'Sunnypivacaine', General anesthesia
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
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