Clinical trials: Locoregional Anaesthesia
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis
Early Mobilization After Total Knee Arthroplasty
Patients undergoing elective total knee arthroplasty are randomized to either intrathecal anesthesia, wound infiltration with local anesthetics and standardized postoperative care (NA = neuraxial anesthesia) or general…
- Trial name
- NCT01604382
- Testing
- General Anesthesia, Neuraxial anesthesia
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Pain
Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients
The purpose of this study is to determine the effectiveness of buffered local anesthesia injections to numb the gums and teeth during dental treatment.
- Trial name
- BufferDent (NCT01622296)
- Testing
- Sodium bicarbonate, Lidocaine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Thoracic Herpes Zoster
Rhomboid Intercostal and Subserratus Plane Block Versus Paravertebral Block for Thoracic Herpes Zoster
Postherpetic neuralgia (PHN) is a common and debilitating complication of herpes zoster, characterized by persistent and severe pain.
- Trial name
- NCT06751680
- Testing
- Rhomboid Intercostal and Subserratus Plane Block, PVB block
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xiaguang Duan
Pain, Tooth Extraction
Rofecoxib and Bupivacaine to Prevent Pain After Third Molar (Wisdom Tooth) Extraction
This study will evaluate the ability of the drugs rofecoxib and bupivacaine to prevent pain following third molar (wisdom tooth) extraction. Rofecoxib is approved to treat pain of arthritis and menstrual cramps.
- Trial name
- NCT00050362
- Testing
- Rofecoxib and Bupivacaine
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Hormones, Anesthesia, Conduction
The Impact of Regional Anaesthesia on Hormone Levels in Thoracic Surgery.
Basic aspects of thoracic anaesthesia are general anesthesia often combined with regional anesthesia, intubation with double lumen tube and separation of lung ventilation.
- Conditions
- Hormones, Anesthesia, Conduction, Thoracic Surgical Procedure
- Trial name
- NCT04414488
- Testing
- Thoracic paravertebral block (ThPVB)
- Where
- Poland
- Volunteers
- 119 people
- Sponsor
- Medical University of Silesia
Thoracic Surgery, Epidural Anesthesia
The Effect of Regional Anesthesia Techniques on Brain Tissue Oxygenation in Thoracic Surgery
Today, it is preferred that the lung with pathology for thorax surgery is not under ventilation during operation in terms of reliability and ease of operation.
- Conditions
- Thoracic Surgery, Epidural Anesthesia, Cerebral Oxygen Saturation
- Trial name
- NCT04373174
- Testing
- Regional oximetry probe, Thoracic Epidural block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Postoperative Pain, Pediatric Surgery
Caudal Epidural Vs. TAP Block for Postoperative Analgesia in Pediatric Infraumbilical Surgery: a RCT
This randomized controlled trial investigates the postoperative analgesic efficacy of caudal epidural block versus ultrasound-guided transversus abdominis plane (TAP) block in pediatric patients undergoing infraumbilical surgery.
- Conditions
- Postoperative Pain, Pediatric Surgery, Anesthesia, Local, Regional Anesthesia
- Trial name
- NCT06895382
- Testing
- Caudal Epidural Block, Transversus Abdominis Plane (TAP) Block, Bupivacaine 0.25%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Namik Kemal University
Anesthesia, Conduction, Pain, Postoperative
Combined PENG and LFCN Block for Total Hip Arthroplasty
A clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. A PENG block will be used in combination with a LFCN block.
- Conditions
- Anesthesia, Conduction, Pain, Postoperative, Arthroplasty, Replacement, Hip
- Trial name
- NCT04996290
- Testing
- PENG + LFCN block, Ropivacaine injection
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Dental Phobia, Dental Anxiety
Assessment of Pain, Anxiety and Efficiency of NumBee Compared to Traditional Local Anesthetic Syringe
The study was conducted among a group of dental patients aged (6-8 years old) of both genders to assess the following variables in the needleless interparliamentary anesthesia (NUMBEE) compared to traditional local anesthesia: 1.
- Conditions
- Dental Phobia, Dental Anxiety, Anesthesia, Local, Needle Phobia
- Trial name
- NCT05899296
- Testing
- dental syringe ( NumBee), Traditional dental syringe
- Where
- Iraq
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duaa Kamal Naji
Anesthesia
Gaze Training on Task Performance Regional Anaesthesia
Regional anaesthesia is the performance of spinal, epidural or peripheral nerve blocks to allow patients to undergo surgery awake and to provide post-operative pain relief.
- Trial name
- NCT04426227
- Testing
- Gaze training, Discovery learning
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Bimalleolar Fractures of the Ankle., Sciatic Nerve Block.
To Compare lidocaine2%/Clonidine in Combination, With Bupivacaine 0.5 % Alone in Equal Volumes for Combined Sciatic-saphenous Nerve Block in Terms of Selectivity of Blockade
Clonidine as an adjuvant to local anaesthetics prolongs the postoperative analgesia. It is predominantly an alpha 2 agonist, but does have some alpha 1 activity. Clonidine alone produces analgesia.
- Conditions
- Bimalleolar Fractures of the Ankle., Sciatic Nerve Block., Saphenous Nerve Block., Post Operative Analgesia Duration.
- Trial name
- NCT01759524
- Testing
- Bupivacaine, Lidocaine
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Cork University Hospital
Postoperative Pain, Peripheral Neuropathy
Duration of Blockade of Peripheral Nerves With Bupivacaine Depending of the Adjuvants
The main aim of the investigator's study is to propose combination of local anesthetics and adjuvants that provides both adequate anesthesia during surgery and prolonged post-operative analgesia.
- Conditions
- Postoperative Pain, Peripheral Neuropathy, Fractures of the Upper Limb, Fracture of the Lower Limb (Except Hip), Initial Encounter
- Trial name
- DBBA (NCT04498923)
- Testing
- Bupivacaine, dexamethasone, epinephrine
- Where
- Ukraine
- Volunteers
- 68 people
- Sponsor
- Lviv National Medical University
Propofol Injection Pain
Comparison of Bier Block and Lidocaine-Propofol Mixture for Prevention of Propofol Injection Pain
The goal of this clinical trial was to evaluate methods to prevent pain on intravenous administration of propofol during induction of anesthesia.
- Trial name
- BBLP (NCT07285980)
- Testing
- propofol, Lidocaine - Propofol Mixture, Lidocaine - Bier Block
- Where
- Tunisia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Asma Ladib
Knee Arthritis, Anesthesia, Local
The Effect of PPB Using 10, 20 and 30 ml of Lidocaine, Study on Volunteers
The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve branches of the sciatic and femoral nerve, when using different volumes of local anesthetics for PPB.
- Conditions
- Knee Arthritis, Anesthesia, Local, Post Surgical Pain
- Trial name
- NCT05464862
- Testing
- Popliteal Plexus Block with 10 ml, Popliteal Plexus Block with 20 ml, Popliteal Plexus Block with 30 ml
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charlotte Runge
Anesthesia, Local
Comparison of Digital Intraosseous and Manual Intraligamentary Anesthesia in Children
The aim of this study is to compare the effects of digital intraosseous anesthesia and manual intraligamentary anesthesia techniques on pain scores during the restorative treatment of permanent mandibular molars in pediatric…
- Trial name
- NCT07524569
- Testing
- Intraligamentary anaesthesia, Digital Intraosseous Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Injection Pain, Local Anesthesia
Efficacy of Virtual Reality in Reducing Injection Pain and Anxiety During Local Anesthesia in Children
The aim of this study is to determine the efficacy of a virtual reality (VR) device in reducing injection pain and anxiety associated with local anesthesia in pediatric dental patients.
- Trial name
- NCT03772483
- Testing
- Local anesthesia with conventional syringe, Local anesthesia with conventional syringe + VR device
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Healthy, Behavior Management
Effect of Vibrasthetic Device on Pain Reduction During Local Anesthesia in Pediatric Patients
The goal of this clinical trial is to test if children aged between 6 and 14 years who are receiving a dental injection will feel less pain by using a vibration device applied to the injection site during the injection compared…
- Trial name
- NCT07306650
- Testing
- Vibrating device, Manual vibration
- Where
- Saudi Arabia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Pain Management
Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial
The main objective of the study is to measure the efficacy of a multimodal postoperative pain regimen consisting of oral acetaminophen and naproxen compared to a traditional opioid-only pain regimen following elective wide awake…
- Trial name
- WALANT (NCT06917118)
- Testing
- Oxycodone 5mg taken first, Acetaminophen, Naproxen Tablets, 500 mg
- Where
- Puerto Rico
- Volunteers
- 100 people
- Sponsor
- University of Puerto Rico
Postoperative Pain
Local Anesthetics After Total Knee Arthroplasty
The aim of this randomized, double-blind and placebo-controlled study is to evaluate the specific role of injection of local anesthetic into the intra- vs. extraarticular tissues after toal knee arthroplasty.
- Trial name
- NCT00518674
- Testing
- local infiltration analgesia
- Volunteers
- 32 people
- Sponsor
- Hvidovre University Hospital
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