Clinical trials: Locoregional Anaesthesia
Pain
Femoral Nerve Block Versus Adductor Canal Nerve Block for Peri-Operative Analgesia Following Anterior Cruciate Ligament (ACL) Reconstruction: Evaluation of Post-operative Pain and Strength
All patients over the age of 16 undergoing primary or revision anterior cruciate ligament reconstruction with the use of bone-patellar-bone autograft are eligible for the study.
- Trial name
- NCT03033589
- Testing
- Marcaine 0.25 % Injectable Solution
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Epidural Catheter, Epidural Analgesia
Epidural Anesthesia for Transurethral Resection of The Prostate
The aim of this study is to assess the effects of different routes of local anesthetic administration in epidural anesthesia applied to patients undergoing transurethral resection of the prostate (TUR-P).
- Conditions
- Epidural Catheter, Epidural Analgesia, Geriatric Cardiology, Urologic Disorders
- Trial name
- NCT06893809
- Testing
- Epidural injection via Tuohy needle, Epidural injection via catheter, Combined epidural injection (needle and catheter)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Chronic Pain
Bacteriostatic Normal Saline Versus Lidocaine for Intradermal Anesthesia
The purpose of this study is to determine if creation of a skin wheel with bacteriostatic normal saline, which includes 0.9% benzyl alcohol, is less painful and provides a similar level of anesthesia compared to 1% lidocaine.
- Trial name
- NCT04495868
- Testing
- Bacteriostatic Normal Saline, 1% Lidocaine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Migraine Disorders
Greater Occipital and Supraorbital Nerve Blockade in Migraine Patients
The investigators aimed to evaluate the efficacy of greater occipital nerve and supraorbital nerve blockade with local anesthetics for the preventive treatment of migraine without aura.
- Trial name
- NCT03435185
- Testing
- Lidocaine injections, Saline injections
- Volunteers
- 103 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Postoperative Pain
An International Trial to Evaluate the Efficacy and Safety of SABER®-Bupivacaine for Postoperative Pain Control in Patients Following Arthroscopic Shoulder Surgery
The objective is to identify the optimal dose of SABER-Bupivacaine for postoperative pain control in patients undergoing elective arthroscopic shoulder surgery on the basis of pharmacokinetics, efficacy and safety evaluations.
- Trial name
- NCT00993798
- Testing
- SABER-Bupivacaine Treatment 1a, Bupivacaine HCl Treatment 1c, SABER-Bupivacaine Treatment 2a
- Where
- 10 sites in Austria, Germany and 3 more
- Volunteers
- 107 people
- Sponsor
- Durect
Rib Fractures
Continuous Intercostal Nerve Blockade for Traumatic Rib Fractures
Rib fractures are common injuries in accident patients and can be associated with significant pain during recovery. If poorly controlled, pain from splinting due to rib fractures can result in difficulty in breathing leading to…
- Trial name
- NCT02604589
- Testing
- hydromorphone hydrochloride, Infusion catheter placement, bupivicaine 0.25%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Anthony Iacco
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Other Surgical Procedures
Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine
Clinical aim: Does reducing the dose of local anesthetic in ultrasound-guided axillary plexus anesthesia have any effect on the success rate and additional parameters of block quality? Methodology: In this prospective cohort…
- Trial name
- NCT01309360
- Testing
- midazolam, prilocaine 1%
- Volunteers
- 120 people
- Sponsor
- Helios Research Center
Pain Management
Regional Anesthesia to Reduce Opioid Use Following Functional Endoscopic Sinus Surgery
Opioids are prescribed for moderate to severe pain disorders; however, there are contraindications and side effects that are common to all opioids.
- Trial name
- NCT03757715
- Testing
- Bupivacaine, Dexamethasone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Alabama at Birmingham
Breast Surgery
Erector Spinae Versus Paravertebral Nerve Blocks for Breast Surgery
Following painful surgical procedures of the breast, postoperative analgesia is often provided with a paravertebral nerve block (PVB).
- Trial name
- NCT03549234
- Testing
- Erector Spinae (single injection), Paravertebral (single injection)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Anesthesia, Local, Pain Control
Should Maxillary Buccal Infiltration Anesthesia be Given in a Closed Mouth Technique?
To study the patients' and dentists' perception of receiving/ administering maxillary buccal infiltration anesthesia using an open or closed mouth techniques
- Trial name
- NCT03921190
- Testing
- Local anesthesia
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Osteoarthritis of Hip, Regional Anesthesia
Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement
The purpose of this research study is to evaluate the analgesic efficacy of adding a single shot parasacral (sciatic) nerve block to a continuous lumbar plexus block in patients undergoing total hip replacement.
- Conditions
- Osteoarthritis of Hip, Regional Anesthesia, Other Acute Postoperative Pain, Total Hip Arthroplasty
- Trial name
- NCT02161484
- Testing
- Continuous Lumbar Plexus Block, Parasacral Nerve Block, Ropivacine 0.2%
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rita Merman
Infertility
Experience of Pain During Oocyte Retrieval- a Comparison Between Two Aspiration Needles
The purpose of the study is to compare the pain experience between the patients that have had their transvaginal oocytes retrieval with ultrasound guidance performed with reduced single lumen needle (Vitrolife Sweden AB…
- Trial name
- NCT00924885
- Testing
- Swemed Follicle Aspiration Set Reduced Single Lumen, Swemed Follicle Aspiration Set Single Lumen (1.4 mm)
- Where
- 4 sites in Sweden
- Volunteers
- 257 people
- Sponsor
- Vitrolife
Pain, Phantom, Pain, Neuropathic
Valproic Acid for the Prevention of Post-Amputation Pain
The objectives of this study are, to test the effectiveness of Valproic Acid (VPA) in the prevention of chronic neuropathic and post-amputation pain, as well as to further define the underlying inflammatory and epigenetic…
- Trial name
- NCT01928849
- Testing
- Valproic Acid, Cherry Syrup
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Pain, Procedural
The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
The purpose of this study is to compare patient responses during and after surgery when local anesthetic is used for dental treatment under general anesthesia (GA) and when it is not used.
- Trial name
- NCT04500158
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Trigger Finger
Needle-Free Injection of Lidocaine for Local Anesthesia Prior to Trigger Digit Injection
Jet-injection (J-tip) is a rapid, minimally invasive delivery system that can be used for the subdermal injection of lidocaine solution for anesthetic purposes.
- Trial name
- J-tip (NCT02084706)
- Testing
- Triamcinolone (20 g) and 2% Lidocaine injection over the A1 pulley, 2% Lidocaine, Triamcinolone (20 g)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04513652
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Breast Surgery
Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery
Following painful surgical procedures of the breast, postoperative analgesia is often provided with a paravertebral nerve block (PVB).
- Trial name
- NCT03860974
- Testing
- Serratus Plane block (single injection), Paravertebral block (single injection)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Thoracic Surgical Procedures
Erector Spinae Plane vs. Paravertebral Nerve Block for Thoracic Surgery
Continuous paravertebral analgesia and erector spinae plane blockade (ESP) are accepted techniques at University of Pittsburgh Medical Center (UPMC) for the management of thoracic pain following surgery and trauma.
- Trial name
- NCT03758261
- Testing
- Paravertebral nerve block, Erector Spinae nerve block
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Charles Luke
Total Knee Arthroplasty
Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural, with or without a femoral nerve block, or FNB.
- Trial name
- NCT01333943
- Testing
- Study Group: Experimental, Control Group
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hospital for Special Surgery, New York