Clinical trials: Locoregional Anaesthesia
Nerve Pain, Shoulder Pain
The Effect of Dexmedetomidine on Brachial Plexus Block for Shoulder Surgery
The purpose of this study is to determine whether a small dose of Dexmedetomidine, when given either intravenously or as part of the interscalene nerve block solution, prolongs pain relief following shoulder surgery compared to…
- Trial name
- DEX (NCT02225054)
- Testing
- Dexmedetomidine, Ropivacaine, Normal Saline
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Women's College Hospital
Local Anesthesia
Buffered Anesthetic Solution in the Treatment of Mandibular Primary Molars
In a prospective, randomized clinical trial, triple-blind, split-mouth study, 40 children aged between 7 to 10 with bilateral mandibular primary molars were diagnosed with pulpitis.
- Trial name
- NCT05793905
- Testing
- Buffered lidocaine in inferior alveolar nerve block injection, lidocaine 2% in inferior alveolar nerve block injection
- Where
- Syria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Damascus University
Pediatric Anesthesia
Variation of Cerebral Blood Flow in Anterior Cerebral and Basilar Artery in Neonates and Infants in Genreal Anesthesia With Caudal Block
With this study we want to see how the blood flow in the anterior cerebral artery (ACA) and the basilar artery (BA) after the caudal block changes.
- Trial name
- NCT02761954
- Volunteers
- 50 people
- Sponsor
- Bürgerhospital Frankfurt
Endodontic Inflammation
Comparison of Osteocentral Versus Locoregional Anesthesia in Case of Mandibular Molar Pulpitis
The irreversible acute pulpitis is the most common emergency at the hospital during dental consultation. Pulpitis are characterized by intense and spontaneous oro-facial pains.
- Trial name
- COQ (NCT03802305)
- Testing
- computerized intraosseous technique (Quicksleeper™), loco-regional anesthesia (IANB technique)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Postoperative Pain, Wrist Fracture
Comparing Efficacity of Analgesia Between Ultrasound-guided Nerve Block and Local Infiltration After Wrist Fracture Surgery
Distal radial fracture reparations by volar plating are often managed under regional anaesthesia, but are associated with severe pain when the block ends.
- Trial name
- BNINF (NCT02693288)
- Testing
- Local infiltration anesthesia
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anesthesia, Pediatric Surgery
Intravenous Dexmedetomidine as an Adjuvant to Locoregional Anesthesia in Pediatric Surgery
The main objective of this study is to study the impact of intravenous dexmedetomidine combined with locoregional anesthesia on postoperative pain in children undergoing surgery.
- Trial name
- DEXPED (NCT06736483)
- Testing
- Dexmedetomidine, Face Legs Activity Cry Consolability scale, Post-Hospitalization Behavior Questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Dental Anxiety, Pain
Effect of Therapeutic Play and Virtual Reality Glasses on Pain and Anxiety in Children
Background: A child's first dental experience plays a crucial role in treatment success and in fostering cooperation during future visits.
- Trial name
- NCT07375056
- Testing
- Intervention 1: Therapeutic Play Group, Intervention 2: Virtual Reality Glasses Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Breast Neoplasm Female, Regional Anesthesia
PECS-2 for Breast Surgery
There is no consensus regarding which alternative is the best anesthesia for breast surgery, general anesthesia and morphine for postoperative analgesia or a combination of regional anesthesia and general anesthesia that possibly…
- Conditions
- Breast Neoplasm Female, Regional Anesthesia, Anesthesia, Regional Anesthesia Morbidity
- Trial name
- NCT03117894
- Testing
- Ropivacaine 5 mg/ml, 35 ml, Remifentanil 50 microg/ml, Betamethason 4 mg
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Umeå University
Symptomatic Irreversible Pulpitis
Assessment of Local Anaesthesia Effectiveness in Symptomatic Irreversible Pulpitis
This study aims to evaluate the comparative efficacy of two different local anaesthetic agents for supplemental buccal infiltration after a failed inferior alveolar nerve block in achieving profound pulpal anaesthesia for…
- Trial name
- LA AGENTS (NCT06862570)
- Testing
- 2% lignocaine with epinephrine 1.8 ml(36mg/ml lignocaine HCL, epinephrine bitartrate 0.0324mg/ml), 4% Articaine with epinephrine 1.7 ml (40mg/ml Articaine HCL, epinephrine bitartrate 0.018 mg/ml)
- Where
- Pakistan
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- 28 Military Dental Centre Lahore
Pain
S-Caine™ Peel (Skin Numbing Cream) to Treat Pain During Pulsed Dye Laser (PDL) Therapy in Adults
Pulsed dye laser (PDL) on the face is painful. For this reason, local anesthesia is commonly used to eliminate or minimize the pain.
- Trial name
- NCT00110773
- Testing
- S-Caine™ Peel (lidocaine and tetracaine topical cream 7%/7%)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- ZARS Pharma Inc.
Elective Cesarean Section
Influence of Surgical Regional Anesthesia on Postoperative Pain
To compare three Types of anesthetic techniques (Spinal anesthesia, Combined spinal epidural anesthesia, Combined spinal epidural anesthesia with indwelling catheter for 24 hrs) on pain after elective cesarean section.
- Trial name
- CESAR (NCT01234662)
- Testing
- SPA, CSE, CSEPCEA
- Where
- Germany
- Volunteers
- 171 people
- Sponsor
- Charite University, Berlin, Germany
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a…
- Trial name
- NCT01567839
- Testing
- Mandibular buccal Infiltration injection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Total Knee Anthroplasty, Regional Anesthesia
The Sacral Erector Spinae Plane Block in Total Knee Arthroplasty
The goal of this observational study is to learn about the analgesic efficacy and postoperative recovery of two locoregional anesthesia combinations in patients > 18 years (ASA I-III), scheduled for unilateral TKA under spinal…
- Trial name
- sacral ESP (NCT07017400)
- Testing
- Local Anesthetic Injection
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- San Giovanni di Dio Hospital
Discharge Time, Ambulatory Surgery
Different Local Anesthetic Volumes for Unilateral Spinal Anesthesia
Varicose veins are irreversible and abnormal enlargement of the veins. These veins appear and there are curled swellings under the skin in the feet and legs. Complaints increase when standing and sitting for long periods.
- Conditions
- Discharge Time, Ambulatory Surgery, Spinal Anesthesia
- Trial name
- NCT06527430
- Testing
- 4 mg bupivacaine, 6 mg bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara Etlik City Hospital
Vascular Access
Radial ABG Sampling: A RCT of Lidocaine Local Anaesthesia
Arterial Blood Gas (ABG) sampling is a common procedure in all hospitals worldwide. Often, ABG samples are obtain from inserting a needle into the radial artery at the wrist - this procedure is often painful and dreaded by…
- Trial name
- NCT02125565
- Testing
- Injected subcutaneous local (lidocaine) anaesthesia
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Mr Ryckie George Wade
Neuralgia, Peripheral Neuropathic Pain
Randomized Controlled Trial of Efficacy and Safety of Local Anesthetics and Steroids for Chronic Peripheral Post-traumatic Neuropathic Pain
The purpose of this study is to evaluate three different injectable solutions used to block ankle nerves to manage ankle pain. The current standard of medical care is to inject a combination of local anesthetics and steroids…
- Trial name
- RESPERIST (NCT03009500)
- Testing
- Bupivacaine, Depo-Medrol Injectable Product, Saline (Sodium Chloride) solution
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University Health Network, Toronto
Pain, Postoperative
Ketolorac Versus Saline at Laparoscopic Incision Sites
Pain control following surgery is a critical aspect of patient care. Pain at incision sites in laparoscopic surgery contributes to overall pain felt by a patient.
- Trial name
- NCT01374828
- Testing
- Ketolorac
- Where
- United States
- Sponsor
- The Cleveland Clinic
Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS)
Erector Spinae Plane Block in Uniportal VATS
The main aim of this study is to compare the effectiveness of three alternative techniques (continuous Erectus Spinae Plane Block : c-ESPB; continuous Serratus Anterior Plane Block : c-SAPB; and Intercostal Nerve Block: ICNB) in…
- Conditions
- Thoracic Surgery, Uniportal Video Assisted Thoracic Surgery (U-VATS), Lung Resections, Post-Operative Pain, Chronic
- Trial name
- ESPB-UVATS (NCT04892901)
- Testing
- c-ESPB, c-SAPB, ICNB
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
End Stage Renal Disease (ESRD), Arteriovenous Fistula Patency
Anesthetic Effect of Ropivacaine on Local Infiltration Anesthesia in Arteriovenous Fistula Surgery
This study compares two local anesthetics, ropivacaine and lidocaine, for patients undergoing arteriovenous fistula surgery. Arteriovenous fistula is the preferred vascular access for end-stage kidney disease patients needing…
- Conditions
- End Stage Renal Disease (ESRD), Arteriovenous Fistula Patency, Chronic Kidney Disease 5D
- Trial name
- NCT07259772
- Testing
- Ropivacaine, Lidocaine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First People's Hospital of Lianyungang
Anesthesia
Jet Injectors Versus Conventional Anesthetic Technique in Children
This clinical study was conducted to compare the needleless Comfort-in jet injector device and the conventional needle technique in terms of 1. Pain level during the administration of local anesthesia in children. 2.
- Trial name
- NCT06314984
- Testing
- Group I A (Conventional needle syringe), Group I B (Conventional needle syringe), Group II A (Comfort-in Jet Injector)
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mansoura University
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