Clinical trials: Locoregional Anaesthesia
Dental Crowding, Dental Occlusion, Traumatic
Exploration of the Utility of Dental-dedicated MRI for Dentistry
This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images.
- Conditions
- Dental Crowding, Dental Occlusion, Traumatic, Endodontic Disease, Orthodontic Treatment
- Trial name
- NCT06948162
- Testing
- dental-dedicated MRI (ddMRI)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anesthesia, Local, Photodamaged Skin
Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
The purpose of this study is to determine the efficacy of lidocaine 2.5%/prilocaine 2.5% cream versus lidocaine 23%/tetracaine 7% ointment for topical anesthesia prior to a nonablative laser procedure.
- Conditions
- Anesthesia, Local, Photodamaged Skin, Topical and Infiltration Anesthetic Toxicity
- Trial name
- NCT04523961
- Testing
- 2.5 g of lidocaine 23% / tetracaine 7% ointment without occlusion, 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream with occlusion
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Post Operative Local Anaesthesia
Laparoscopic Guided Transversus Abdominis Plane Block Versus Trocar Site Infiltration in Gynecologic Laparoscopy.
to compare between Laparoscopic Guided Transversus Abdominis Plane Block and Trocar Site Infiltration as postoperative analgesia in Gynecologic Laparoscopic surgery.
- Trial name
- NCT02973451
- Testing
- Laparoscopic Guided Bupivacaine, local Bupivacaine
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Breast Cancer Surgery, Postoperative Pain, Acute
Chronic Pain in Post-Mastectomy Patients; The Difference Between Pectoral Nerve (PECS I-II) and Erector Spinal Plane (ESP) Blocks
This study looks at two types of injections (called PECS and ESP blocks) to see which one works better for reducing pain after breast cancer surgery (mastectomy).
- Conditions
- Breast Cancer Surgery, Postoperative Pain, Acute, Postoperative Pain, Chronic, Post-mastectomy Pain Syndrome
- Trial name
- NCT06900842
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hacettepe University
Local Anesthesia
Effect of Sodium Bicarbonate Buccal Infiltration on the Success of Inferior Alveolar Nerve Block
The purpose of this prospective, randomized, double blind study was to evaluate the effect of a buccal infiltration of sodium bicarbonate on the anesthetic success of the inferior alveolar nerve block (IANB) in patients with…
- Trial name
- NCT02726737
- Testing
- sodium bicarbonate, Lidocaine, sterile distilled water
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Masoud Saatchi
Healthy Volunteers
Local Anaesthetic Effects of Transcutaneous Amitriptyline
The aim of this study is to assess the local anaesthetic effects of amitriptyline applied on the skin of human volunteers, considering the differential effects on mechanic and thermic sensitivity, the local and general tolerance…
- Trial name
- NCT00355277
- Testing
- Amitriptyline
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics IIIb
The purpose of this study are to compare the efficacy of two different commercially available local anesthetics on AFXL pretreated skin and to assess the role of the application time in this technique.
- Trial name
- NCT03279757
- Testing
- AHES 5 minutes, AHES 15 minutes, AHES 25 minutes
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Anesthesia, Obstetric
Regional Anaesthesia
Spinal anesthesia is an established technique used in obstetric surgeries, It provides adequate analgesia both intra and post-operative and also avoids complications associated with general anesthesia for mother and fetus.
- Trial name
- NCT06055101
- Testing
- DEXMEDETOMIDINE, Neostigmine, Bupivacaine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Reham Ali Abdelhaleem Abdelrahman
Postoperative Cognitive Dysfunction, Orthopedic Procedures
Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery
This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia.
- Conditions
- Postoperative Cognitive Dysfunction, Orthopedic Procedures, Postoperative Pain Management, Hip Fracture
- Trial name
- REMIND-ORTHO (NCT07113483)
- Testing
- Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO]
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Tooth Extraction
Infiltration Anesthesia vs. Block Anesthesia
Checking the effectiveness of the infiltration technique of local anesthetic agent as an alternative to inferior dental nerve block during tooth extraction
- Trial name
- LAI (NCT06766981)
- Testing
- Infiltration with Articain 4%, Inferior Alveolar Nerve Block
- Where
- 2 sites in Iraq
- Volunteers
- 100 people
- Sponsor
- Sinan A. Shwailiya
Cancer
Trial of Methoxyflurane With Periprostatic Local Anaesthesia to Reduce the Discomfort of TRUS B
A phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasound-guided prostate biopsy (Pain-Free TRUS B).
- Trial name
- TRUSB (NCT02604225)
- Testing
- Methoxyflurane
- Where
- 7 sites in Australia, New Zealand
- Volunteers
- 420 people
- Sponsor
- University of Sydney
Trigger Finger Disorder
Wide Awake Local Anesthesia No Tourniquet
The main objective is to assess patient's satisfaction regarding pure local anaesthesia and without use of a tourniquet (WALANT Technique) for trigger finger release surgery.
- Trial name
- WALANT (NCT03663608)
- Testing
- WALANT Technique
- Where
- 2 sites in France
- Volunteers
- 57 people
- Sponsor
- Rennes University Hospital
Ultrasound-Guided Nerve Block and Artificial Intelligence
Agreement Between Artificial Intelligence and Anesthesiologists in Ultrasound-Guided Axillary Brachial Plexus Block
This prospective observational study aims to evaluate the agreement between artificial intelligence (AI)-assisted target point identification and experienced anesthesiologists during ultrasound-guided axillary brachial plexus…
- Trial name
- NCT07532278
- Testing
- Ultrasound-Guided Axillary Brachial Plexus Block (Routine Clinical Practice)
- Volunteers
- 100 people
- Sponsor
- Gaziantep City Hospital
Anesthesia, Local
Articaine Infiltration in Anesthetizing Mandibular Second Primary Molars
Background: Articaine hydrochloride has steadily grown in popularity, and studies have shown that articaine hydrochloride performs better than lidocaine due to an enhanced anes-thetic efficacy.
- Trial name
- NCT06201949
- Testing
- Articaine infiltration technique, Articaine nerve block technique
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Hams Hamed Abdelrahman
Postoperative Pain
Comparative Study of the Analgesic Effect of Spinal Anesthesia or Infiltration Anesthesia for Hemorrhoidectomy
Background and Objectives: Postoperative analgesia and early recovery are relevant for hospital discharge after hemorrhoidectomy.
- Trial name
- NCT02839538
- Testing
- Local Infiltration, Subarachnoidal block
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Anesthesia, Local
Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population
The primary aim of this study is to evaluate the pharmacokinetics of serum ropivacaine concentrations following erector spinae plane peripheral nerve blocks in the pediatric population.
- Trial name
- NCT04298099
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Baylor College of Medicine
Pain, Patient Satisfaction
Patient-Controlled Sedation in Port Implantation (PACSPI-2)
The goal of the study is to determine if patient-controlled sedation (PCS) with propofol and alfentanil reduces patient-reported pain perception during implantation of subcutaneous venous port (SVP).
- Conditions
- Pain, Patient Satisfaction, Cancer, Venous Puncture
- Trial name
- PACSPI-2 (NCT05688384)
- Testing
- Propofol + Alfentanil
- Where
- Sweden
- Volunteers
- 340 people
- Sponsor
- Region Jönköping County
Osteoarthritis, Knee
Perineural Steroids for Peripheral Nerve Blocks
This study will look at the efficacy of dexamethasone for prolongation of peripheral nerve blocks.
- Trial name
- NCT02462148
- Testing
- Dexamethasone, Bupivacaine, Epinephrine
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Post Operative Cognitive Dysfunction
Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction
Post-operative cognitive dysfunction is defined as a decrease in cognitive functions which develop following surgery and anesthesia administration that can last up to weeks or even months after surgery.
- Trial name
- NCT03290599
- Testing
- Mini Mental and Modified Mini Mental Test
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Burcu Ozalp Horsanali
Malignant Melanoma
Anesthesia and Cancer Recurrence im Malignant Melanoma
Studies in animals and retrospective studies in humans show that regional anesthesia reduces metastatic cancer dissemination. The investigators hypothesize that in patients suffering from malignant melanoma who have to undergo…
- Trial name
- NCT01588847
- Testing
- Spinal anesthesia with Bupivacaine hyperbar 0.5 %, General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane
- Where
- Germany
- Volunteers
- 230 people
- Sponsor
- University Hospital Muenster
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