Clinical trials: Long Bone Delayed-Union Fracture
Infected Non Union and Delayed Union in Fractures of Both Long and Short Bones
Hardware Preservation in Management of Infected Non United or Delayed United Fractures of Long or Short Bones by Debridement and Local Calcium Sulfate Loaded by Antibiotics
Diagnosis of infection based on elevated serum markers of infection (ESR, CRP), discharging sinus, preoperative radiographs suggestive of bone infection and radiological findings .
- Trial name
- NCT05231148
- Testing
- local debridement and local calcium sulfate loaded by antibiotics
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sohag University
Delayed Union Fracture, CT-scan
A mRUS Validation Study for Nail-treated Fractures of Long Bones and a TUS Exploratory Study for Nail and Plate-treated Fractures of Long Bones
Early intervention attempts to shorten protracted delayed union (DU) or prevent non-union (NU) fractures are hampered by lack of validated quantitative assessment tools for bone fracture healing during normal and delayed healing…
- Conditions
- Delayed Union Fracture, CT-scan, X-Ray, Bone Fracture
- Trial name
- mRUSTUS (NCT03286270)
- Where
- 4 sites in Germany
- Volunteers
- 173 people
- Sponsor
- Bone Therapeutics S.A
Long Bone Delayed-Union Fracture
Phase 1/2a Study on Allogeneic Osteoblastic Cells Implantation in Delayed-Union Fractures
Fracture healing is a complex physiological process caused by interaction of cellular elements, cytokines and signaling proteins, which results in the formation of new bone.
- Trial name
- NCT02020590
- Testing
- ALLOB® implantation
- Volunteers
- 25 people
- Sponsor
- Bone Therapeutics S.A
Fracture Non Union, Fracture Healing
Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture
In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union).
- Conditions
- Fracture Non Union, Fracture Healing, Long Bone Delayed-Union Fracture, Humerus Shaft Fracture
- Trial name
- BioBone (NCT06658379)
- Testing
- CD8+TEMRA
- Where
- 7 sites in Germany
- Volunteers
- 640 people
- Sponsor
- Charite University, Berlin, Germany
Fractures, Bone
855303-RNA Biomarker Validation
The purpose of this study is to test the accuracy of using RNA in blood as a way to forecast new fracture healing outcome.
- Trial name
- 855303-RNAVal (NCT06872775)
- Testing
- Blood draws to assess RNA expression levels
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Delayed Union After Fracture of Humerus, Tibial or Femur
Evaluation of Efficacy and Safety of Autologous MSCs Combined to Biomaterials to Enhance Bone Healing
Bone grafting is widely used in hospitals to repair injured, aged or diseased skeletal tissue. In Europe, about one million patients encounter a surgical bone reconstruction annually and the numbers are increasing due to our…
- Trial name
- OrthoCT1 (NCT01842477)
- Testing
- Implantation of bone substitute plus autologous cultured mesenchymal cells
- Where
- 5 sites in France, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Fracture, Delayed Union of Fracture
Early Application of Pulsed Electromagnetic Field in the Treatment of Postoperative Delayed Union
The investigators hypothesized that early applied pulsed electromagnetic field treatment on delayed union might lead to increased rate of fracture union and shortened period of treatment.
- Trial name
- NCT01574833
- Testing
- pulsed electromagnetic field
- Where
- China
- Volunteers
- 92 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School