Clinical trials: Long Standing Persistent Atrial Fibrillation
Atrial Fibrillation
a Novel Individualized Substrate Modification Approach for the Treatment of Long-standing Persistent Atrial Fibrillation
The purpose of this study is to compare effectiveness of two substrate modification approaches in long-standing persistent atrial fibrillation patients, and hypothesized that a substrate-based, individualized substrate…
- Trial name
- NCT02477592
- Testing
- individualized substrate modification, stepwise ablation
- Where
- China
- Volunteers
- 220 people
- Sponsor
- RenJi Hospital
Atrial Fibrillation
Hybrid AF -- A Prospective Registry
Atrial Fibrillation (AF) is a form of rapid irregular heart rhythm that starts in the upper chambers of the heart (called atria) and is often associated with many health problems.
- Trial name
- NCT01636518
- Testing
- Standard of Care
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Long Standing Persistent Atrial Fibrillation
Remote Monitoring of AF Recurrence Using mHealth Technology
Atrial fibrillation (AF) is the most common arrhythmia worldwide. It carries a significant health burden, conferring on sufferers a reduction in quality of life, risk of significant morbidities such as stroke and heart failure…
- Trial name
- REMOTE-AF (NCT05037136)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrial Fibrillation
A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF
The DISRUPT-AF Registry is an observational, prospective, multi-center, non-randomized, real-world registry designed to obtain clinical experience with the Farapulse Pulsed Field Ablation System for the treatment of atrial…
- Trial name
- DISRUPT-AF (NCT06335082)
- Testing
- Pulsed Field Ablation
- Where
- 36 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Heart Rhythm Clinical and Research Solutions, LLC
Atrial Fibrillation, Persistent
Thoracoscopic Ablation Versus Catheter Ablation in Patients With Atrial Fibrillation
Despite good progress in the management of patients with atrial fibrillation (AF), this arrhythmia remains one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity in the world.
- Trial name
- TACAAF (NCT04237389)
- Testing
- Ablation Index Guided endocardial catheter radiofrequency ablation, minimally invasive thoracoscopic surgical epicardial ablation.
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- National Research Center of Surgery, Russia
Atrial Fibrillation, Persistent or Longstanding Persistent Atrial Fibrillation
Pivotal Study Of A Dual Epicardial & Endocardial Procedure (DEEP) Approach
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presenting with Persistent Atrial Fibrillation or Longstanding Persistent Atrial…
- Trial name
- DEEP (NCT02393885)
- Testing
- AtriCure Bipolar System and AtriClip® PRO LAA Exclusion System, Endocardial Ablation
- Where
- 17 sites in United States, Belgium and 1 more
- Volunteers
- 90 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
This prospective randomized study aims to investigate the effect of continuous versus interrupted use of Amiodarone on the procedure outcome in long-standing persistent (LSP) atrial fibrillation patients undergoing pulmonary vein…
- Trial name
- SPECULATE (NCT01173809)
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation (AF)
Noninvasive Mapping Before Surgical Ablation
The purpose of this study is to assess the electrophysiological mechanism of atrial fibrillation by means of a beat-to-beat noninvasive 3D mapping method in patients with concomitant persistent and long-standing persistent atrial…
- Trial name
- NIMSA (NCT06803615)
- Testing
- Electrocardiographic imaging
- Where
- Austria
- Volunteers
- 51 people
- Sponsor
- Medical University of Vienna
Atrial Fibrillation
Dual Epicardial Endocardial Persistent Atrial Fibrillation(AF) Study (Staged DEEP)
The purpose of this study is to assess the safety and technical feasibility of treating subjects with Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation in a minimally invasive thoracoscopic ablation…
- Trial name
- Staged DEEP (NCT01661205)
- Testing
- Ablation procedure staged catheter ablation
- Where
- 6 sites in United States, Belgium and 1 more
- Volunteers
- 30 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Effect of Left Atrial Appendage Excision on Procedure Outcome in Patients With Persistent and Long-standing Persistent Atrial Fibrillation Undergoing Surgical Ablation
The aim of this study is to assess the effect of left atrial appendage excision on atrial fibrillation recurrence and incidence of stroke in patients with persistent and long-standing persistent atrial fibrillation undergoing…
- Trial name
- NCT02562391
- Testing
- Surgical ablation of the left atrium (PVI+Box lesions), Surgical ablation of the left atrium (PVI+Box lesions) and left atrial appendage cutting
- Where
- 4 sites in Russia
- Volunteers
- 180 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation, Tachycardia
Long-Standing Persistant Atrial Fibrillation-Pulmonary Vein Isolation With or Without Ablation
The chronic success rate, defined as freedom from any atrial tachyarrhythmias will increase from 35% to 60% by ablation of complex fragmented atrial electrograms potentials in addition to pulmonary vein isolation (PVI) as…
- Trial name
- Alster-Lost (NCT00820625)
- Testing
- pulmonary vein isolation, pulmonary vein isolation with additional ablation of fragmented potentials
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- Asklepios proresearch
Atrial Fibrillation
The Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation
This prospective study aims; 1. To assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome 2.
- Trial name
- IMPACT (NCT01148914)
- Testing
- Inflammatory biomarkers
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation (AF), Persistent Atrial Fibrillation
AtriCure CryoICE Lesions for Persistent and Long-standing Persistent Atrial Fibrillation Treatment
The primary objective of this study is to evaluate the safety and effectiveness of the AtriCure CryoICE system in performing the Cox-Maze III lesion set, in conjunction with Left Atrial Appendage (LAA) exclusion using the…
- Conditions
- Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
- Trial name
- ICE-AFIB (NCT03732794)
- Testing
- AtriCure CryoICE & AtriClip LAA Exclusion
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- AtriCure, Inc.
Long-standing Persistent AF
LS-PersAFone: Pulsed Field Ablation for Long-Standing Persistent Atrial Fibrillation
This is a prospective, single-arm trial. The objective of the study is to determine the rate of atrial arrhythmia recurrence after pulmonary vein isolation (PVI) plus posterior wall isolation (PWI) using the Farawave PFA catheter…
- Trial name
- LS-PersAFone (NCT06128174)
- Testing
- Farawave PFA catheter
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vivek Reddy
Atrial Fibrillation
Second Study to Assess Different Ablation Strategies in Achieving Long-Term Arrhythmia Control in Patients With Persistent or Long Standing Persistent Atrial Fibrillation
Pulmonary vein isolation (PVI) combined with empiric ablation of either common sites of non-PV triggers of Atrial Fibrillation (AF) and locations that may sustain stable AF sources should be more efficacious than PVI combined…
- Trial name
- RASTA XT (NCT02019238)
- Testing
- Pulmonary Vein Isolation procedure
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Persistent Atrial Fibrillation, Long-standing Persistent Atrial Fibrillation
Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation
This study aims to examine the long-term success rate of catheter ablation in non-paroxysmal atrial fibrillation patients using different ablation strategies such as : (i) pulmonary vein antrum isolation (PVAI) + isolation of…
- Trial name
- TANTRA (NCT01672138)
- Testing
- Pulmonary Vein Antrum Isolation, scar homogenization, Non-PV triggers ablation
- Where
- 2 sites in United States
- Volunteers
- 186 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Coronary Artery Disease
Surgical Ablation of Long-standing Persistent AF During CABG
Purpose. Comparison of outcomes in patients underwent CABG combined with left atrial and biatrial radiofrequency ablation of long-standing persistent atrial fibrillation.
- Trial name
- LABARFA (NCT02246790)
- Testing
- Biatrial radiofrequency ablation and CABG, Left atrial radiofrequency ablation and CABG
- Where
- Russia
- Volunteers
- 116 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Atrial Fibrillation
Hybrid Ablation of Persistent and Long-standing Persistent Stand-alone Atrial Fibrillation
This study evaluates in detail efficacy and safety (including neurological safety) of hybrid ablation of stand-alone, persistent and long-standing persistent atrial fibrillation (AF).
- Trial name
- NCT02832206
- Testing
- hybrid ablation
- Where
- Czechia
- Volunteers
- 59 people
- Sponsor
- Charles University, Czech Republic
Atrial Fibrillation
CONVERGE CAP Study-For The Treatment Of Symptomatic Persistent or Long-standing Persistent AF
The objective of this clinical study is to collect additional data on the safety and effectiveness of the EPi- Sense®-AF Guided Coagulation System with VisiTrax® to treat symptomatic persistent or long-standing persistent Atrial…
- Trial name
- CAP (NCT04239534)
- Testing
- Convergence Of Epicardial And Endocardial RF Ablation
- Where
- 10 sites in United States, United Kingdom
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation
Does Atrial Fibrillation (AF) Termination Without Additional Ablation Influence Outcome?
This prospective study aims to investigate if termination of atrial fibrillation (AF) after pulmonary vein antrum isolation (PVAI) without additional ablation of non-PV triggers, in long-standing persistent (LSP) AF, is enough to…
- Trial name
- TARGET (NCT01696344)
- Testing
- PVAI, PVAI + ablation of extraPV triggers
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation