Clinical trials: Long Term Oxygen Therapy
Post-COVID19
Automatic Oxygen Titration in Patients After SARS-CoV-2 Infection
With the progression of the SARS-CoV-2 pandemic there's an increasing number of patients recovering from COVID19. Some of these patients still experience hypoxemia and therefore are still in need of a long-term oxygen therapy…
- Trial name
- NCT04849598
- Testing
- Oxygen therapy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Retinopathy of Prematurity
Time Outside Target Oxygen Saturation Range in Preterm Infants and Long Term Outcomes and Preterm Infants
The purpose of this study is to determine if there is a relationship between time spent out the targeted oxygen saturation range in preterm infants is associated with long-term outcomes such as Retinopathy of Prematurity.
- Trial name
- SAT01ROP (NCT00845624)
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chronic Obstructive Pulmonary Disease (COPD)
High-flow Nasal Cannula Therapy for Stable Chronic Obstructive Pulmonary Disease (COPD)
This is a prospective, randomized crossover study for evaluation of the efficacy and safety of long-term nocturnal high-flow nasal cannula therapy with the myAIRVO2® in stable COPD patients with stage 2-4 of the Global Initiative…
- Trial name
- NCT02545855
- Testing
- High-flow nasal cannula therapy, Home oxygen therapy (HOT)
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
COPD, Hypoxemia
Automated Oxygen Titration at Home in Patients With COPD on Home Oxygen
Twelwe patients with COPD and long term oxygen treatment (LTOT) will be included in the study. An automated home oxygen titrations (HOT) device will be attached to the patient´s home oxygen equipment.
- Trial name
- DaiLiHOT_2 (NCT05556187)
- Testing
- Individualized automated oxygen titration
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
ILD, COPD
Impact of Remote Vital Signs Monitoring in People Using Long-term Oxygen Therapy
Assess quality of life of patients using prolonged oxygen therapy
- Trial name
- ILD; COPD (NCT06882265)
- Testing
- Group Monitoring, Control Group
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Pulmonary Fibrosis, Pulmonary Hypertension
A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary Hypertension
A randomized, double-blind, placebo-controlled dose escalation and verification study to assess the safety and efficacy of pulsed inhaled nitric oxide (iNO) in subjects at risk for pulmonary hypertension associated with pulmonary…
- Trial name
- REBUILD (NCT03267108)
- Testing
- INOpulse®, Open Label Extension
- Where
- 64 sites in United States, Canada
- Volunteers
- 145 people
- Sponsor
- Bellerophon Pulse Technologies
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non Invasive Ventilation for COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) patients are more likely to develop acute hypercapnic respiratory failure. In the acute phase, non invasive ventilation has been shown to improve mortality and reduce intubation rate.
- Trial name
- NIVOLD (NCT03221101)
- Testing
- Home ventilator
- Where
- 4 sites in France
- Volunteers
- 86 people
- Sponsor
- University Hospital, Rouen
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
3 Part Study to Assess Inhaled Nitric Oxide on Functional Pulmonary Imaging in Subj. Pulmonary Hypertension Associated w/ COPD and IPF
The objective of this exploratory study is to examine the utility of high resolution computed tomography (HRCT) to measure changes in functional pulmonary imaging parameters as a function of short term a) iNO administration and…
- Conditions
- Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis
- Trial name
- NCT02267655
- Testing
- inhaled Nitric Oxide - 30 mcg/kg IBW/hr, inhaled Nitric Oxide 5,10,15 mcg/Kg IBW/hr, inhaled nitric oxide 75 mcg/kg IBW/hr
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- Bellerophon
Chronic Respiratory Disease
Observing Physiological Changes in Patients With Long-term Oxygen Therapy
In this project, the investigators aim to assess changes of physiological parameters obtained non-invasively through PPG and accelerometry signals between before and during LTOT (long-term oxygen therapy) and investigate if those…
- Trial name
- NCT06525857
- Testing
- LTOT
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Peripheral Arterial Disease
Clinical and MRI Cardiac Biomarkers on Peripheral Arterial Disease in Patients With Long Term DM
The aim of this study is to establish a clinically feasible simultaneous evaluation of heart and lower limb using MRI and to assess the combined benefit of clinical and cardiac MRI imaging markers in the evaluation of PAD and…
- Trial name
- CMRPADDM (NCT02850432)
- Testing
- Invasive treatment, Conservative treatment
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
COPD
A Prospective Observational Study of the Breath Responsive Variable Bolus Oxygen Conserving Device
Evaluate subjects in an prospective observational study Subjects will be administered scientifically validated questionnaires Evaluate Quality Improvement and Oxygen Utilization Improvements. 1.
- Trial name
- BRVB-OCD (NCT02627599)
- Testing
- Breath Responsive Variable Bolus Oxygen Conserving Device
- Where
- 3 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- StratiHealth
Pulmonary Arterial Hypertension
Study of PAH Subjects With LTOT Use That Have Demonstrated Improved Exercise Tolerance With the Use of Inhaled Nitric
Study of PAH Subjects with LTOT Use that have Demonstrated Improved Exercise Tolerance with the use of Inhaled Nitric Oxide
- Trial name
- NCT03602781
- Testing
- iNO
- Where
- 4 sites in United States, Canada
- Sponsor
- Bellerophon Pulse Technologies
Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
Two-Part Dose-Confirming Study of Pulsed Inhaled Nitric Oxide in Subjects With WHO Group 3 Pulmonary Hypertension Associated With COPD
This is a placebo-controlled, double-blind, parallel, randomized, two-part, dose-confirming clinical study characterizing the pharmacodynamic effects of pulsed iNO using the combination product, inhaled nitric oxide/INOpulse DS-C…
- Trial name
- NCT01728220
- Testing
- Inhaled NO delivered via INOpulse DS-C Device
- Where
- 43 sites in United States
- Volunteers
- 159 people
- Sponsor
- Bellerophon Pulse Technologies
Exercise Therapy, Physical Activity
HOPE (Home-based Oxygen [Portable] and Exercise) for Patients on Long Term Oxygen Therapy (LTOT)
Long term oxygen therapy (LTOT) is proven to increase the survival of patients with respiratory failure, most commonly from diseases such as Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Exercise Therapy, Physical Activity, Respiratory Failure, Oxygen Inhalation Therapy
- Trial name
- HOPE (NCT03662438)
- Testing
- Home-based physiotherapy program, Prescription of a Portable Oxygen Concentrator (POC) device
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore General Hospital
COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy
Study of Default Options in Advance Directives
Default options represent the events or conditions that are set into place if no alternatives are actively chosen. The setting of default options has well-established effects on a broad range of human decisions, but its influence…
- Conditions
- COPD, Severe or Very Severe Airflow Obstruction and/or Receiving or Eligible to Receive Long-term Oxygen Therapy, Idiopathic Pulmonary Fibrosis, Other Interstitial Lung Disease Without Curative Therapy
- Trial name
- NCT01817686
- Testing
- Comfort Default AD forms, Life Extension Default AD forms, Standard Default AD forms
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Chronic Obstructive Pulmonary Disease
Long-term Oxygen Treatment (LTOT) in Chronic Obstructive Pulmonary Disease: Factors Influencing Survival
The purpose of this prospective cohort study is to determine factors involved in survival in new COPD patients treated by long-term oxygen therapy. Background: long-term oxygen therapy is indicated in patients with severe COPD.
- Trial name
- NCT00871962
- Testing
- OXYGEN SUPPLEMENTATION
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
COPD, Chronic Hypoxemic Respiratory Failure
Automated Oxygen Titration with O2matic Home Oxygen Therapy (O2matic HOT) Phase 1
O2matic HOT is a further development of O2matic and is intended for home oxygen use with patients in need of long-term oxygen treatment (LTOT).
- Trial name
- O2matic-HOT1 (NCT04606290)
- Testing
- O2matic HOT, Oxygen concentrator
- Where
- 2 sites in Denmark
- Volunteers
- 10 people
- Sponsor
- Hvidovre University Hospital
COPD, COPD - Chronic Obstructive Pulmonary Disease
Respiratory Oxygen Adherence Monitor for Chronic Obstructive Pulmonary Disease Patients
The goal of this clinical trial is to test a device called "ROAM" that is being developed to see how patients with chronic obstructive pulmonary disease (COPD) use oxygen therapy over a long period of time.
- Trial name
- ROAM (NCT06874101)
- Testing
- Activated ROAM System with User Feedback
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Barron Associates, Inc.
Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
In this randomized-controlled, cross-over trial the investigators test the effect of long-term oxygen therapy (> 16h/day) given for 5 weeks with a wash-out period between phases of 2 weeks on exercise performance and quality of…
- Trial name
- NCT01884012
- Testing
- long term oxygen therapy
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Pulse Oximeter Validation, Long Term Oxygen Therapy
Validation of a Miniature SpO2 Sensor in Healthy Subjects and Patients With Long-term Oxygen Therapy.
By integrating a miniaturized pulse oximetry sensor into the frame of oxygen delivery glasses which dissimulates the nasal cannula, the investigators hope to optimize and long term oxygen therapy (LTOT) regarding medical and…
- Conditions
- Pulse Oximeter Validation, Long Term Oxygen Therapy, Hypoxemia
- Trial name
- OxyFrame (NCT02723032)
- Testing
- OxyFrame
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern