Clinical trials: Long-term Effects of Cancer Treatment
Melanoma
A Retrospective Observational Study on the Long-term Effects of Ipilimumab-treated Pediatric Participants in the Dutch Melanoma Treatment Registry (DMTR)
This is an observational, national, retrospective study consisting of pediatric patients with advanced (spread or unremoveable) melanoma identified in the DMTR in the Netherlands
- Trial name
- NCT04196452
- Testing
- Ipilimumab
- Volunteers
- 10 people
- Sponsor
- Bristol-Myers Squibb
Quality of Life, Cognitive Impairment
Long Term Implications of Rare Brain Tumours'
Patients diagnosed with oligodendroglioma with a specific molecular profile represent rare tumour groups (about 10% of adult gliomas) with relatively favourable prognosis (median survival between 8 and 12 years).
- Conditions
- Quality of Life, Cognitive Impairment, WHO Grade II Oligodendroglial Tumor, WHO Grade III Oligodendroglial Tumor
- Trial name
- NCT04708548
- Testing
- Health-related Quality of Life, Psychological Distress, Fatigue
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Galina Velikova
Depression, Sleep
The Long-term Effects of Body-mind-spirit Group Therapy
Aims and objectives: This study aims to examine the effects of the body-mind-spirit group therapy on marital close relationships, sleeping quality, depression, quality of life, meaning of life, and salivary cortisol levels in…
- Trial name
- NCT01727635
- Testing
- body-mind-spirit group therapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia
Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
This clinical trial is looking at brain function in young patients receiving methotrexate for acute lymphoblastic leukemia. Learning about the long-term effects of methotrexate on brain function may help doctors plan cancer…
- Conditions
- Childhood B Acute Lymphoblastic Leukemia, Childhood T Acute Lymphoblastic Leukemia, Cognitive Side Effects of Cancer Therapy, Long-Term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00437060
- Testing
- Cognitive Assessment, Diffusion Tensor Imaging, Laboratory Biomarker Analysis
- Where
- 112 sites in United States, Australia and 2 more
- Volunteers
- 233 people
- Sponsor
- Children's Oncology Group
Non-small Cell Lung Cancer, Nivolumab
Cohort of Patients With NSCLC Treated With Nivolumab Under the ATU Program
Our study sought to examine nivolumab efficacy and safety in advanced NSCLC patients treated under the Temporary Authorization for Use (ATU, compassionate use) setting and describe their long-term clinical characteristics…
- Conditions
- Non-small Cell Lung Cancer, Nivolumab, Long-term Adverse Effects
- Trial name
- CLINIVO (NCT02933346)
- Where
- 72 sites in France
- Volunteers
- 907 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Colorectal Cancer, Fatigue
Patient-Reported Outcomes in Long-Term Survivors of Colon and Rectal Cancers
RATIONALE: Learning about quality of life, symptoms, and health behaviors in colorectal cancer survivors may help to determine the long-term effects of colon and rectal cancer treatments and may help to improve the quality of…
- Conditions
- Colorectal Cancer, Fatigue, Long-term Effects Secondary to Cancer Therapy in Adults, Pain
- Trial name
- NCT00410579
- Testing
- Telephone interview
- Where
- 200 sites in United States
- Volunteers
- 744 people
- Sponsor
- NSABP Foundation Inc
Rectal Cancer
MMP-7 Modulation by Short and Long Term Radiotherapy in Rectal Cancer Patients
To analyse the effects of radiation therapy on inflammation and matrilysin levels in rectal cancer patients.
- Trial name
- MMP-7 (NCT03151759)
- Testing
- Neoadjuvant radiotherapy
- Volunteers
- 77 people
- Sponsor
- Region Skane
Hodgkin's Disease, Lymphoma
Evaluation of Late Treatment Effects in Long-Term Survivors of Hodgkin's Disease Previously Treated at NIH: A Multi-Institutional Trial
Background: Researchers are greatly interested in knowing more about the long-term effects of various treatments for cancers such as Hodgkin's disease, particularly from those who have lived 20 to 30 years after treatment.
- Trial name
- NCT00924131
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- National Cancer Institute (NCI)
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications
RATIONALE: A personalized Internet-based program may help improve fatigue, depression, and quality of life in long-term survivors of stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00799461
- Testing
- internet-based intervention, questionnaire administration, psychosocial assessment and care
- Where
- United States
- Volunteers
- 1,337 people
- Sponsor
- Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Cardiotoxicity, Cardiomyopathies
The Cardio-Oncology Breast Cancer Study
The main objective of this randomized controlled trial is to test the association between standard cardiac risk factors, biomarkers and parameters of echocardiography, electrocardiography, and cardiac magnetic resonance imaging…
- Conditions
- Cardiotoxicity, Cardiomyopathies, Breast Cancer
- Trial name
- COBC (NCT02571894)
- Testing
- Subclinical cardiotoxicity surveillance and treatment
- Where
- Sweden
- Volunteers
- 320 people
- Sponsor
- Karolinska University Hospital
Breast Cancer
Long-term Effects of Breast Cancer Treatment
The objective of this project is to generate evidence about quality of life related to side effects of treatment of women with screen-detected versus symptomatic breast cancer.
- Trial name
- NCT03877029
- Where
- Norway
- Volunteers
- 4,487 people, healthy volunteers welcome
- Sponsor
- Norwegian Institute of Public Health
Long-term Effects Secondary to Cancer Therapy in Adults, Lymphoma
Observation in Patients With Diffuse Large B-Cell Non-Hodgkin's Lymphoma Treated on Clinical Trial CAN-NCIC-LY9
RATIONALE: Treatment for diffuse large B-cell non-Hodgkin's lymphoma may cause side effects and secondary cancers later in life.
- Trial name
- NCT00400907
- Testing
- clinical observation, management of therapy complications
- Volunteers
- 667 people
- Sponsor
- German High-Grade Non-Hodgkin's Lymphoma Study Group
Old Age; Debility, Digestive Cancer
Multicomponent Prehabilitation and Outcomes in Elderly Patients With Frailty
The study is designed to investigate the effect of a multicomponent prehabilitation pathway on early and long-term outcomes in elderly patients with frailty recovering from surgery for digestive cancer.
- Conditions
- Old Age; Debility, Digestive Cancer, Surgery, Preoperative Rehabilitation
- Trial name
- NCT04715581
- Testing
- Preoperative nutritional optimization, Preoperative exercise training, Postoperative exercise training
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Peking University First Hospital
Long-Term Effects Secondary to Cancer Therapy
Tumor Nutritional Therapy in the First-line Treatment of Stage IV NSCLC
A Single-center, Randomized, Controlled Clinical Study Comparing the Efficacy and Safety of Tumor Nutritional Therapy Combined With Immune Checkpoint Inhibitors and Chemotherapy in the First-line Treatment of Stage IV NSCLC…
- Trial name
- NCT06356701
- Testing
- Cancer nutritional treatment regimen (Spirulina Bifidobacterium Capsules, Fish Oil Grape Seed Blueberry Soft Capsules, Ganoderma Spore Oil Soft Capsules)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Barrett's Esophagus, Erosive Esophagitis
To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use
Patients with severe acid reflux and/or Barrett's esophagus are recommended to take Proton pump inhibitors (PPIs)indefinitely to prevent complications such as strictures or the development of a type of esophageal cancer.
- Conditions
- Barrett's Esophagus, Erosive Esophagitis, Gastroesophageal Reflux Disease(GERD)
- Trial name
- BE-CAST (NCT01306799)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Pennsylvania
Leukemia
Study of Metabolic Syndrome in Young Patients Who Are Acute Lymphoblastic Leukemia Survivors and Their Healthy Siblings
RATIONALE: Gathering information about metabolic syndrome from young patients who have survived acute lymphoblastic leukemia (ALL) may help doctors learn more about the disease.
- Trial name
- NCT00897078
- Testing
- laboratory biomarker analysis, medical chart review, metabolic assessment
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Breast Cancer
Strength and Range of Motion in Women Undergoing Surgery for Breast Cancer
RATIONALE: Gathering information about strength and range of motion over time from women undergoing surgery for breast cancer may help doctors learn more about recovery from surgery and on-going care.
- Trial name
- NCT00489125
- Testing
- physiologic testing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Wake Forest University Health Sciences
Bladder Cancer, Cervical Cancer
Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer
RATIONALE: Radiation therapy can cause long-term adverse effects. Hyperbaric oxygen therapy may be effective in lessening gastrointestinal symptoms caused by radiation therapy given for pelvic cancer.
- Conditions
- Bladder Cancer, Cervical Cancer, Colorectal Cancer, Endometrial Cancer
- Trial name
- NCT01087268
- Testing
- questionnaire administration, gastrointestinal complications management/prevention, quality-of-life assessment
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Brain and Central Nervous System Tumors, Cognitive/Functional Effects
Irinotecan and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Solid Tumors
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Cognitive/Functional Effects, Long-term Effects Secondary to Cancer Therapy in Adults, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00389584
- Testing
- irinotecan hydrochloride, cognitive assessment, management of therapy complications
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Davis
Breast Cancer, Chemotherapeutic Agent Toxicity
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
RATIONALE: Gathering information over time from laboratory tests, imaging scans, and assessment tests may help doctors learn more about the side effects of chemotherapy and plan the best treatment.
- Conditions
- Breast Cancer, Chemotherapeutic Agent Toxicity, Cognitive/Functional Effects, Fatigue
- Trial name
- NCT00755313
- Testing
- trastuzumab, aromatase inhibition therapy, carboplatin
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco