Clinical trials: Long-term Outcomes
Growth Disorders
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Australia
This is an Australian, Multicentre, Observational Registry to study Adherence and Long Term Outcomes of Therapy in paediatric subjects using easypod™ electromechanical device for growth hormone treatment to assess the level of…
- Trial name
- ECOS AUS (NCT01309555)
- Testing
- easypod™
- Where
- Australia
- Volunteers
- 33 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Bone Defect
FlexiOss® - Efficacy, Safety and Long-term (Radiological and Clinical) Outcomes During Comprehensive Care Continuum of Implanted Biocomposite for Bone Regeneration.
The aim of this clinical study is to evaluate the efficacy, safety and long-term (radiological and clinical) outcomes during comprehensive care continuum of implanted biocomposite for bone regeneration FlexiOss® compared to the…
- Trial name
- FlexiOssOT (NCT07209033)
- Testing
- FlexiOss®, Allogenic human bone grafting
- Where
- 2 sites in Poland
- Volunteers
- 80 people
- Sponsor
- Medical Inventi S.A.
Acute Pulmonary Embolism (PE), Pulmonary Embolism
Evaluating the Efficacy, Safety and Long Term Functional Outcomes of Percutaneous Mechanical Aspiration Thrombectomy for Treatment of Acute Pulmonary Embolism Using the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System
To evaluate the efficacy, safety, and long-term functional outcomes of percutaneous mechanical aspiration thrombectomy using the AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System for the treatment of acute pulmonary…
- Trial name
- RECOVER-AV (NCT06697314)
- Testing
- AlphaVac Multipurpose Mechanical Aspiration (MMA) F1885 System
- Where
- Poland
- Volunteers
- 256 people
- Sponsor
- Angiodynamics, Inc.
Retinopathy of Prematurity
Extension Study to Evaluate the Long-Term Outcomes of Pediatric Patients Who Received Treatment for Retinopathy of Prematurity in the VGFTe-ROP-1920 Study (Acronym: Butterfleye Next)
Primary objectives of the study are: To evaluate binocular visual acuity at the end of this study in patients included from the VGFTe-ROP-1920 study, for treatment of Retinopathy of Prematurity (ROP).
- Trial name
- NCT04515524
- Testing
- Non-Interventional
- Where
- 30 sites in United States, Bulgaria and 8 more
- Volunteers
- 100 people
- Sponsor
- Regeneron Pharmaceuticals
Advanced Idiopathic Parkinson's Disease
Long-term Study of Duodopa (Levodopa/Carbidopa) in Advanced Parkinson's: Health Outcomes & Net Economic Impact
The primary objective of this study is to collect health economic data depicting the initial levels and natural progression over time of resource usage, Parkinson's disease (PD)-related costs, and health related quality of life…
- Trial name
- DAPHNE (NCT00141518)
- Testing
- Levodopa-carbidopa intestinal gel (LCIG), CADD-Legacy® 1400 ambulatory infusion pump, percutaneous endoscopic gastrostomy tube (PEG tube)
- Volunteers
- 77 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Ablation of Arrhythmia's
AcQMap® Global Registry of Procedural and Long-term Clinical Outcomes (AcQMap Registry)
AcQMap Registry is an observational study
- Trial name
- DISCOVER (NCT03893331)
- Testing
- AcQMap System
- Where
- 12 sites in France, Germany and 2 more
- Volunteers
- 479 people
- Sponsor
- Acutus Medical
Diabetes
Global Long-term Outcomes and Real-World Evaluation of Dexcom Continuous Glucose Monitoring System (Dexcom GLOW)
Global Registry study
- Trial name
- NCT07681024
- Testing
- Dexcom CGM (Continuous Glucose Monitor)
- Volunteers
- 5,000 people
- Sponsor
- DexCom, Inc.
Prostate Cancer (Adenocarcinoma)
Registry to Evaluate Long-Term Outcomes in Patients Who Undergo 68-Ga-PSMA-11 PET/CT Imaging Evaluations
The purpose of this observational research registry is to understand the real-world use of Illuccix PET/CT in prostate cancer, and how results from this testing impact patient's treatment and prostate cancer journey over time.
- Trial name
- NCT06655064
- Testing
- None- Observational
- Where
- 9 sites in United States
- Volunteers
- 120 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Limited
Growth Disorders
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Middle East
This is a Middle East, Multicenter, Observational Study to evaluate Adherence and Long Term Outcomes of Therapy in pediatric subjects using easypod™ electromechanical device for growth hormone treatment and to assess the level of…
- Trial name
- ECOS UAE (NCT02015286)
- Testing
- easypod™
- Where
- Germany
- Volunteers
- 7 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Diabetes Mellitus, Type 2
RECORD: Rosiglitazone Evaluated for Cardiac Outcomes and Regulation of Glycaemia in Diabetes
This study is a phase 3b, multicentre, randomised, open label, parallel group study. A 4-week run-in period will be followed by a median of 6 years of treatment with study medication in addition to continuation of background…
- Trial name
- RECORD (NCT00379769)
- Testing
- Rosiglitazone, Sulfonylurea, Metformin
- Where
- 446 sites in Australia, Belgium and 23 more
- Volunteers
- 4,447 people
- Sponsor
- GlaxoSmithKline
Neovascular Age-related Macular Degeneration
Extension Study to Evaluate the Long-term Outcomes of Subjects in the CLS-AX CLS1002-101 Study
This is an open-label, non-interventional extension study of up to 12 weeks in duration in subjects completing Cohorts 2, 3, and 4 of the Parent study, CLS1002-101.
- Trial name
- NCT05131646
- Testing
- CLS-AX
- Where
- 7 sites in United States
- Volunteers
- 15 people
- Sponsor
- Clearside Biomedical, Inc.
Pulmonary Arterial Hypertension
A Prospective Non-interventional Observational Study to Observe Long-term Treatment and Outcomes in Pulmonary Arterial Hypertension (PAH) Patients
The goal of this observational study is to learn about the long-term development and outcomes of different treatment patterns of patients who initially participated in the TripleTRE study.
- Trial name
- TripleTRE-NIS (NCT06445673)
- Where
- 18 sites in Austria, Czechia and 7 more
- Volunteers
- 110 people
- Sponsor
- AOP Orphan Pharmaceuticals AG
Non-small Cell Lung Cancer (NSCLC)
Long-Term Safety Outcomes and First-Line Treatment Patterns in Patients With Non-Small Cell Lung Cancer and Programmed Death-1 (Pd-L1) <1%
The purpose of this study is to assess the treatment-related adverse events and associated healthcare resource use in programmed death ligand 1 (PD-L1) negative individuals diagnosed with advanced/metastatic non-small cell lung…
- Trial name
- NCT07215962
- Testing
- Nivolumab + ipilimumab, Nivolumab + ipilimumab + platinum-based chemotherapy, Immuno-oncology-based therapy (excluding nivolumab-based regimens) with chemotherapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Bristol-Myers Squibb
Cardiac Transplant Failure, Cardiac Transplant Rejection
Outcomes AlloMap Registry: the Long-term Management and Outcomes of Heart Transplant Recipients With AlloMap Testing
The objective of this registry is to observe short and long term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance.
- Conditions
- Cardiac Transplant Failure, Cardiac Transplant Rejection, Heart Diseases
- Trial name
- OAR (NCT01833195)
- Where
- 36 sites in United States
- Volunteers
- 2,444 people, healthy volunteers welcome
- Sponsor
- CareDx
Vaginal Prolapse
Observational Data Collection of Surgical Outcomes in the Treatment of Vaginal Prolapse With AMS Products
This registry was observational (only collected information typically noted by the surgeon when their patients were routinely seen); there was no change to the care the patient received as a result of being part of the registry).
- Trial name
- POWER1012 (NCT00388947)
- Testing
- AMS Prolapse Product
- Where
- United States
- Volunteers
- 1,543 people
- Sponsor
- ASTORA Women's Health
Open Angle Glaucoma
Study of the CycloPen Micro-Interventional System and Long-Term Clinical Outcomes
This observational study will enroll adults with open angle glaucoma (OAG) who had surgery to reduce intraocular pressure (IOP) using the CycloPen Micro-Interventional System.
- Trial name
- CREST (NCT05506423)
- Testing
- CycloPen Cyclodialysis System
- Where
- 16 sites in United States, Panama
- Volunteers
- 300 people
- Sponsor
- Iantrek, Inc.
Growth Disorders
Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in Czech Republic
This is Multicentre, Observational Study to study Adherence and Long Term Outcomes of Therapy in paediatric subjects using easypod™ electromechanical device for growth hormone treatment to assess the level of adherence of subject…
- Trial name
- ECOS CZ (NCT01400997)
- Testing
- easypod™
- Where
- Czechia
- Volunteers
- 206 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Growth Disorders
To Assess the Level of Adherence of Subjects Receiving SAIZEN® Via Easypod™ in the UK
This is a National, Multicentre, Observational Registry to study Adherence and Long Term Outcomes of Therapy in paediatric subjects using Easypod™ electromechanical device for growth hormone treatment from hospital in the UK and…
- Trial name
- ECOS UK (NCT01263457)
- Testing
- Easypod
- Where
- 6 sites in United Kingdom
- Volunteers
- 191 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Language Development
STEM (Science, Technology, Engineering & Math) Familia Talk
After development of the Talk Stem Familia (TSF) smart-speaker application prototype, the study will evaluate the prototype's efficacy in a within-subjects pre-post design study.
- Trial name
- NCT03766906
- Testing
- Talk STEM Familia app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Osteoarthritis, Knee, Arthritis, Rheumatoid
Evaluation of Medium Cross-linked Polyethylene With and Without Vitamin E for Total Knee Arthroplasty
Prospective, randomized, single-blind, multinational, long-term study for the evaluation of the clinical outcome, oxidation profile and wear analysis of medium cross-linked Polyethylene with and without Vitamin E for total knee…
- Conditions
- Osteoarthritis, Knee, Arthritis, Rheumatoid, Intra-Articular Fractures, Joint Instability
- Trial name
- VIKEP (NCT04618016)
- Testing
- UHMWPE with Vitamin E, UHMWPE without Vitamin E
- Where
- 8 sites in France, Germany
- Volunteers
- 605 people
- Sponsor
- Aesculap AG