Clinical trials: Long-term Outcomes
Depression - Major Depressive Disorder, Bipolar
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health Trajectories
Behavioural Development, Long-term Outcomes and Opportunities to Optimize Youth Mental Health (BLOOM) is a project that aims to overcome age and diagnostic boundaries to generate person-specific longitudinal profiles of mental…
- Conditions
- Depression - Major Depressive Disorder, Bipolar, Psychosis, Eating Disorder NOS
- Trial name
- BLOOM (NCT06978452)
- Where
- Canada
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
HIV Infections
An Observational Study of Long-term Outcomes of HIV-1 Infection in Persons Who Become HIV-1 Infected After Enrollment in HIV-1 Vaccine Trials
An observational study of long-term outcomes of HIV-1 infection in persons who become infected after enrollment in HIV-1 vaccine trials
- Trial name
- NCT03337906
- Testing
- Observation
- Where
- 21 sites in United States, Dominican Republic and 4 more
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- HIV Vaccine Trials Network
COVID-19, SARS-CoV-2 Infection
COVID-19 Observational Research Collaboratory
This study aims to examine the long-term outcomes in Veterans infected and uninfected with SARS-CoV-2 using electronic health record information and structured surveys.
- Trial name
- CORC LTO (NCT05394025)
- Where
- 6 sites in United States
- Volunteers
- 479 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Metabolic Disease, Neurological and Mental Health Conditions
Singapore PREconception Study of Long-Term Maternal and Child Outcomes
We aim to test the following primary hypothesis that nutrition, lifestyle, and maternal emotional health prior to pregnancy and/or during the first trimester alter the expression of metabolic or neurodevelopmental endophenotypes…
- Conditions
- Metabolic Disease, Neurological and Mental Health Conditions, Genetics Predisposition, Skin Condition
- Trial name
- S-PRESTO (NCT03531658)
- Where
- Singapore
- Volunteers
- 1,054 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Coronary Artery Disease, Obesity
Cardiovascular Outcomes Of Diet Counseling
(1) What effect does behavioral counseling for vegan, for low to moderate fat, and for lowered carbohydrate diets have on coronary blood flow? (2) What are the effects of different diet protocols when caloric intake and exercise…
- Trial name
- NCT00324545
- Testing
- Medium-intensity Minimally-directive Counseling
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Camelot Foundation
Longitudinal Studies, Prospective Studies
Clinical Time and Temporal Dynamics Study (CLIN-TIME)
TH-CLINICAL-TIME is a prospective, longitudinal observational study evaluating how changes in clinical measurements over time may help researchers better understand patient health trajectories and clinically meaningful outcomes.
- Conditions
- Longitudinal Studies, Prospective Studies, Biomarkers, Predictive Value of Tests
- Trial name
- CLIN-TIME (NCT07812831)
- Testing
- No Study-Assigned Intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Obesity
Using Novel Behavioral Approaches to Improve Long-Term Weight Loss Outcomes
This project is a randomized controlled trial to compare the efficacy of two interventions- one based on Acceptance and Commitment Therapy (ACT) and one based on Self-Regulation (SR)- and a control group (called weight loss only…
- Trial name
- NCT02156752
- Testing
- ACT, SR, WLO
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Hip Dysplasia, Legg-Calvâe-Perthes Disease
Mixed-Methods Evaluation of Short-, Medium-, and Long-Term Outcomes Following Hip Treatment
This study, titled "Mixed-Methods Evaluation of Short-, Medium-, and Long-Term Outcomes Following Hip Treatment," aims to assess the long-term effectiveness of treatments for pediatric hip conditions, including hip dysplasia…
- Conditions
- Hip Dysplasia, Legg-Calvâe-Perthes Disease, Avascular Necrosis of Hip
- Trial name
- NCT06891196
- Testing
- Long-term Follow-up Surveys
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Burn
Multicenter Benchmarking of Functional and Psychosocial Outcomes of Pediatric Burn Survivors
The purpose of this study is to establish an expected recovery trajectory (recovery model) in terms of physical and psychological function of the pediatric burn patient.
- Trial name
- NCT00239668
- Where
- 4 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Air Pollution, mHealth Intervention
1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh
Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking.
- Conditions
- Air Pollution, mHealth Intervention, Cardiopulmonary Function, Immune Function
- Trial name
- GEOHealth-II (NCT05570552)
- Testing
- mHealth based behavioral change communication intervention
- Where
- Bangladesh
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Non-melanoma Skin Cancer
Post-market Multi-Center RETRO-Prospective Study to Assess Long-term Clinical Outcomes NMSC Patients Treated With eBx
The purpose of this retrospective-prospective study is to evaluate lesions after treatment for BCC or SCC NMSC in order to gain a better understanding of the durability of the treatment, and risk of late toxicities for this…
- Trial name
- NCT05257486
- Testing
- Xoft eBx
- Where
- 2 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Xoft, Inc.
Dravet Syndrome, Depression
LEONIDaS Caregivers Study
Dravet syndrome is a rare form of severe epilepsy that begins in the first year of life and is associated with frequent and/or prolonged seizures.
- Conditions
- Dravet Syndrome, Depression, Anxiety
- Trial name
- LEONIDaS (NCT05140122)
- Testing
- Multiple
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Oxford
Varicose Veins of Lower Limb
Long Term Study of 3 Radiofrequency Devices
To establish which of the radiofrequency venous ablation modalities studied in the original 3RF study (Venefit (Closurefast), vs. Radiofrequency induced Thermal Therapy vs.
- Trial name
- 3RF-5Years (NCT04720027)
- Testing
- Duplex imaging
- Where
- United Kingdom
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Worcestershire Acute Hospitals NHS Trust
Language Development
STEM (Science, Technology, Engineering & Math) Familia Talk
After development of the Talk Stem Familia (TSF) smart-speaker application prototype, the study will evaluate the prototype's efficacy in a within-subjects pre-post design study.
- Trial name
- NCT03766906
- Testing
- Talk STEM Familia app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Primary Percutaneous Coronary Intervention
Influence Of Incomplete Revascularization on Long-Term Outcomes After Primary Percutaneous Coronary Intervention (PPCI)
evaluate the influence of incomplete revascularization during the index hospitalization on in-hospital and long-term outcomes in STEMI patients undergoing PPCI in Assiut University heart hospital.
- Trial name
- NCT04332250
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Amany Edward Ramzy
Primary Percutaneous Coronary Intervention
Thin Versus Thicker Strut Thickness Stents in Primary Percutaneous Intervention
1. To evaluate clinical safety of the device in terms of Deaths, any stroke and Myocardial Infarction up to 1 year in both study groups to prove non inferiority of biomime stent 2.
- Trial name
- NCT06914089
- Testing
- The BioMime is an ultra-thin strut (65 µm) SES that uses a cobalt-chromium platform with a unique hybrid design of open cells in the mid segment and closed cells at the edges
- Where
- Egypt
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Assiut University
COVID-19 Patients
Investigating Long-term Health Effects and Complications in COVID-19 Recoveries
Clarify the incidence of functional impairments in cured COVID-19 patients and identify influencing factors. Build a multi-omics database for COVID-19 patients in the recovery period to elucidate the biological biomarkers and…
- Trial name
- NCT06349720
- Testing
- respiratory rehabilitation
- Where
- China
- Volunteers
- 17,000 people, healthy volunteers welcome
- Sponsor
- Zhaohui Tong
Renal Dysfunction, Hypertension
Effect of Obesity on Long-term Clinical Outcomes After Kidney Donation
Several studies have shown that renal function in patients who have donated a kidney (but are otherwise healthy) remains stable and within normal limits.
- Trial name
- R-21 (NCT01368822)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Osteoporosis
The Oswestry Metabolic BONE Cohort
Osteoporosis is a chronic condition characterised by reduced bone mass and microarchitectural deterioration of bone tissue leading to fracture.
- Trial name
- OsBONE (NCT07014306)
- Testing
- MRI, Computed tomography
- Where
- United Kingdom
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Opioid Withdrawal, Chronic Pain
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid…
- Trial name
- ACTION (NCT06442566)
- Testing
- Buprenorphine Patch, Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina