Clinical trials: Longitudinal Heart Strain
Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer
ANTthracycline-induced Inflammation and OXidative Stress: 10-year Follow-up
The goal of this observational study is to learn about the long-term effects of anthracycline chemotherapy on inflammation, oxidative stress, and heart function in adult women with breast cancer.
- Conditions
- Cardiotoxicity, Anthracycline Related Cardiotoxicity in Breast Cancer, Breast Cancer
- Trial name
- ANTIOX-10 (NCT07680855)
- Volunteers
- 17 people
- Sponsor
- University of Chile
Mitral Regurgitation, Heart Failure
Strain Imaging in Patients With Functional Mitral Regurgitation, Treated With MitraClip
The aim of this study is i) to evaluate left ventricular global longitudinal strain and myocardial work in patients with heart failure and severe functional mitral regurgitation one year after MitraClip implantation and compare…
- Trial name
- NCT04218578
- Testing
- speckle tracking analysis of transthoracic echocardiogram
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Type 2 Diabetes
Prevention of Heart Failure in Type 2 Diabetes by Exercise Intervention
Global longitudinal strain emerged as an important predictive marker that could be assessed during echocardiography. It enabled the detection of subclinical myocardial systolic dysfunction, without observable reductions in…
- Trial name
- PROTECTION (NCT05023538)
- Testing
- Cycling
- Where
- 2 sites in Belgium
- Volunteers
- 182 people
- Sponsor
- Hasselt University
Cardiopulmonary Bypass, Coronary Artery Bypass
GLS in Difficult CPB Weaning
The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac…
- Conditions
- Cardiopulmonary Bypass, Coronary Artery Bypass, Heart Valve Diseases, Echocardiography
- Trial name
- NCT07390903
- Testing
- Myocardial strain imaging
- Where
- 2 sites in Italy, Turkey (Türkiye)
- Volunteers
- 213 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Type2 Diabetes, Heart Failure
Effect of Ertugliflozin on Cardiac Function in Diabetes
The aim of this study is to investigate the beneficial role of ertugliflozin, a new SGLT2 inhibitor, in cardiac function via measuring GLS as well as other hemodynamic factors using echocardiogram in patients with T2D and HF, who…
- Trial name
- ERTU-GLS (NCT03717194)
- Testing
- Ertugliflozin
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Soo Lim
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
Aortic Stenosis
A Comparison of Advanced Imaging Techniques in Aortic Stenosis
In patients with aortic stenosis the valve through which blood is pumped out of the main heart chamber is narrowed. This results in heart muscle working harder to open the valve so blood can circulate around the body.
- Trial name
- AIm-AS (NCT01775215)
- Testing
- Cardiac I123-MIBG Scintigraphy, Cardiac MRI, Stress and rest Echocardiogram
- Where
- United Kingdom
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Atrioventricular Block, Conduction System Pacing
Impact of Atrioventricular Delay Optimization on Ventricular Function in Conduction System Pacing
Conduction system pacing has emerged as a physiological pacing strategy that preserves ventricular electrical activation and minimizes pacing-induced dyssynchrony.
- Trial name
- OPTI-CSP (NCT07624552)
- Testing
- Echocardiography-Guided Atrioventricular Delay Optimization
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Peripheral Arterial Disease, Myocardial Injury
Cardiovascular Risk in Peripheral Artery Disease Patients Undergoing Endovascular Revascularisation
This study will investigate heart-related complications in patients with peripheral arterial disease (PAD) undergoing endovascular revascularization procedures to improve blood flow in the legs.
- Conditions
- Peripheral Arterial Disease, Myocardial Injury, Troponin, NT-proBNP
- Trial name
- RISK (NCT07599540)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Cardiomyopathy
Evaluate the Efficacy of Disopyramide Therapy in Hypertrophic Obstructive Cardiomyopathy Patients
Population study- patients with obstructive hypertrophic cardiomyopathy that are treated with disopyramide. Tow echo examination, few hours apart, that includes strain rate will be done to each patient.
- Trial name
- NCT02917395
- Testing
- echocardiography
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Myocardial Infarct
STunning in Acute Myocardial Infarction - BAS
The objective of this trial is to examine the effect of immediate versus late administration of beta blockers, angiotensin converting enzyme inhibitors (ACEI), and sodium/glucose cotransporter 2 (SGLT2) inhibitors on…
- Trial name
- STAMI-BAS (NCT06562582)
- Testing
- Bisoprolol Oral Tablet, Ramipril Oral Product, Dapagliflozin Oral Product
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Vastra Gotaland Region
Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).
- Conditions
- Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Global Cardiac Wall Motion Dysfunction
- Trial name
- NCT05650008
- Testing
- Intrathecal local anesthesia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Postoperative Complications
Left Ventricular Global Longitudinal Strain and Postoperative Myocardial Injury
To use left ventricular global longitudinal strain as a means of monitoring myocardial exercise function during anaesthesia in patients with coronary artery disease, to explore the association with the occurrence of postoperative…
- Trial name
- NCT05392426
- Testing
- Left Ventricular Global Longitudinal Strain, EF CO SV EDV ESV
- Where
- 2 sites in China
- Volunteers
- 58 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Heart Failure Acute, Heart Failure
Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University…
- Conditions
- Heart Failure Acute, Heart Failure, Echocardiography
- Trial name
- STRATS-AHF (NCT03513653)
- Testing
- Echocardiography with speckle-tracking imaging
- Where
- 3 sites in South Korea
- Volunteers
- 4,312 people
- Sponsor
- Seoul National University Hospital
Cardiac Resynchronization Therapy
Comparison of Multi-point Pacing and Conventional CRT Through Non-invasive Hemodynamics Measurement and Global Longitudinal Strain Assessment
Pilot, perspective, multi-center non-randomized study comparing Multi-point pacing and conventional CRT through non-invasive hemodynamics measurement and Global Longitudinal Strain assessment
- Trial name
- COMPACT-MPP (NCT04299360)
- Testing
- Cardiac Resynchronization Therapy device programming
- Where
- 3 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Azienda Ospedaliera Universitaria Mater Domini, Catanzaro
Heart Failure With Preserved Ejection Fraction
Finerenone and Cardiac Remodeling in HFpEF
This prospective randomized study aims to evaluate the efficacy of Finerenone as add-on therapy to standard of care compared to standard of care alone in preventing heart failure worsening and preserving cardiac function assessed…
- Trial name
- NCT07830940
- Testing
- Finerenone, Standard of care for HFpEF Description:
- Volunteers
- 194 people
- Sponsor
- Assiut University
Cardiovascular Diseases
Assessment of Global Longitudinal Strain for the Prediction of Anthracycline Induced Cardiotoxicity
Anthracycline therapy is well-known for its adverse cardiac effects. Anthracycline-induced cardiotoxicity (AIC) is associated with a poor prognosis; since classical heart failure treatment can potentially reverse cardiac…
- Trial name
- Anthracardio (NCT02875171)
- Testing
- Anthracycline administration
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Versailles Hospital
Left Ventricular Dysfunction
Cardiac Function and Microcirculation: Type 2 DIABetes and ECHOcardiographic Changes Over Time
The purpose of this study was to investigate the influence of micro- and macrovascular changes on the cardiac function in relation to left ventricular function and coronary arteries during one year in patients with type 2…
- Trial name
- DIABECHO (NCT02956577)
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Svendborg Hospital
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Cardioprotective Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists in Korean Patients With Type 2 Diabetes
This observational study will evaluate the cardiovascular effects of sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors) and glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists) in Korean adults with type…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases, Stage B Heart Failure
- Trial name
- NCT07770737
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Dongtan Sacred Heart Hospital
Breast Neoplasm Female, Lymphoma
Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study
Breast cancer is the most common cancer among women worldwide. Similarly, Hodgkin and non- Hodgkin lymphomas make up two of the most prevalent cancers in men and women.
- Conditions
- Breast Neoplasm Female, Lymphoma, Cardiotoxicity, Anthracyclines
- Trial name
- NCT03850171
- Testing
- Exercise Training
- Where
- 4 sites in Switzerland
- Volunteers
- 57 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern