Clinical trials: Loop Electrosurgical Excision
Pregnancy Outcome
Cervical Morphological Changes on Pregnancy Outcome
This study aims to assess how the proportion of the cervical volume/length removed during treatment for cervical intraepithelial neoplasia (CIN) varies and whether this correlates to the pregnancy duration at delivery
- Trial name
- NCT03242746
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Cervical Intraepithelial Neoplasia
Music Listening to Reduce Pain and Anxiety During LEEP
Loop electrosurgical excision procedure (LEEP) is the primary diagnostic and therapeutic procedure employed in women with high-grade intraepithelial neoplasia of the cervix.
- Trial name
- NCT02398916
- Testing
- Music listening
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Chiang Mai University
Cervical Intraepithelial Neoplasia
Cryotherapy vs. LEEP to Treat Cervical Intraepithelial Neoplasia (CIN) 2/3 Among HIV-positive Women
The purpose of this study is to compare the rate of recurrence of cervical intraepithelial neoplasia among HIV-positive women receiving cryotherapy versus LEEP over 2 years of follow-up and to compare the shedding of HIV-1 from…
- Trial name
- PHE-LEEP (NCT01298596)
- Testing
- Loop Electrosurgical Excision Procedure (LEEP), Cryotherapy
- Where
- Kenya
- Volunteers
- 400 people
- Sponsor
- University of Washington
Cervical Cancer
Molecular Imaging for Detection of Cervical Intraepithelial Neoplasia
The hypothesis of this research project is that topical application of the anti-EGFR or anti-E6/E7 contrast agents followed by optical imaging will yield images that reflect spatial variations in expression that correlate with…
- Trial name
- NCT00511615
- Testing
- Loop Electrosurgical Excision Procedure (LEEP)
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Cervical Intraepithelial Neoplasia
Immediate Treatment vs Colposcopic Follow-up for Biopsy-Proven CIN 1
This study looks at immediate treatment of a cervix with CIN 1 versus regular six-month follow-up with colposcopy and treatment if CIN 1 progresses.
- Trial name
- NCT00156026
- Testing
- loop electrosurgical excision procedure (LEEP)
- Where
- 10 sites in Brazil, Canada
- Volunteers
- 415 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Cervical Dysplasia
Construct Validity of a Large Loop Excision of the Transformation Zone (LLETZ) Training Model
In a prospective case-control study, 140 medical students (,novices') and 10 Senior gynecologists (,experts') will perform a Large Loop Excision of the Transformation Zone (LLETZ) on a Training model afte having undergone a Video…
- Trial name
- LLETZ-1 (NCT02476500)
- Testing
- LLETZ on a training model
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Uterine Cervical Dysplasia
Lidocaine Spray Compared With Submucosal Injection During LEEP: a Randomized Controlled Trial
Loop Electrosurgical Excision Procedure (LEEP) is a widely used minor surgical procedure for diagnosis and treatment of cervical intraepithelial neoplasia.
- Trial name
- NCT01505920
- Testing
- Lidocaine spray, Lidocaine submucosal injection
- Where
- Thailand
- Volunteers
- 101 people
- Sponsor
- Chiang Mai University
Human Papillomavirus, High-Grade Squamous Intraepithelial Lesions
Safety and Efficacy Study of TVGV-1 Vaccine to Treat HPV Induced Cervical HSIL
The purpose of this research study is to test the safety and effectiveness of the investigational study vaccine, called TVGV-1. The study will test the vaccine in women with high grade HPV cervical infection.
- Trial name
- NCT02576561
- Testing
- TVGV-1, GPI-0100
- Where
- 11 sites in United States
- Volunteers
- 10 people
- Sponsor
- THEVAX Genetics Vaccine
HSIL, High Grade Squamous Intraepithelial Lesion, CIN 2
Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2
This study evaluates the efficacy and safety of ALA-PDT versus LEEP in treating cervical HSIL/CIN2, aiming to demonstrate non-inferiority in clinical efficacy.
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesion, CIN 2, HPV (Human Papillomavirus)-Associated, Photodynamic Therapy (PDT)
- Trial name
- PDT for CIN2 (NCT07306260)
- Testing
- ALA-PDT, LEEP surgery
- Where
- 5 sites in China
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cervical Dysplasia
Large Loop Excision of the Transformation Zone During Follicular Vs. Luteal Phase of the Menstrual Cycle (LLETZ-MC)
Cervical cancer is one of the most common cancers in women and one of the leading causes of death in women worldwide. Pre-cancerous lesions (dysplasias) are detected by the preventive smear test at the gynecologist and can thus…
- Trial name
- LLETZ-MC (NCT05391243)
- Testing
- LLETZ
- Where
- Germany
- Volunteers
- 152 people
- Sponsor
- Ruhr University of Bochum
Vaginal Bleeding, Loop Electrosurgical Excision
Use of Chitosan Powder in Loop Electrosurgical Excision Procedure
Early treatment of cervical intraepithelial neoplasia (CIN) II-III gives rise to a decrease in the incidence of invasive cervical cancer.
- Trial name
- NCT05661708
- Testing
- Chitosan
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Anesthesia
Impact of Anaesthesia Mode on Evaluation of LEEP Specimen Dimensions
To study the influence of anaesthesia (local by cervical block vs. general or spinal anaesthesia) on height and volume of resection specimens in case of conization treatment for cervical intraepithelial neoplasia (CIN).
- Trial name
- LEEP-DIM (NCT03737526)
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens